GAP-43 Antibody

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GAP43 (growth associated protein 43, also called B-50, PP46, calmodulin-binding protein P-57, neuromodulin, neuron growth-associated protein 43, protein F1) is a major component of motile "growth cones" that form the tips of elongating axons as well as the synaptic plasma membranes. GAP43 is associated with nerve growth process and plays a key role in axonal as well as dendritic filopodia induction. It has been detected in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN, and binds calmodulin with superior affinity in the absence of Ca2+ than in its presence. Intracellular Ca2+ regulates PKC mediated phosphorylation of GAP43 and affects GAP43's ability to bind calmodulin. GAP43 is integral to growth cone formation, neurite outgrowth, and the development of a functional cerebral cortex. Aberrant expression of GAP43 has been seen in patients diagnosed with schizophrenia and Alzheimer's disease.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: ICC/IF, IHC-Fr.

Showing Publications 1 - 4 of 4.

Publications using NBP1-92714	Applications	Species
Staszkiewicz R, Gralewski M, G?adysz D et al. Evaluation of the concentration of growth associated protein-43 and glial cell-derived neurotrophic factor in degenerated intervertebral discs of the lumbosacral region of the spine Molecular pain 2023-02-03 [PMID: 36733259] (IHC-Fr, Human)	IHC-Fr	Human
Powers RM, Daza R, Koehler AE et al. Growth cone macropinocytosis of neurotrophin receptor and neuritogenesis are regulated by neuron navigator 1 Molecular biology of the cell 2022-06-01 [PMID: 35352947] (ICC/IF, Human) Details: Dilution used for ICC 1:250	ICC/IF	Human
Mo J, Anastasaki C, Chen Z et al. Humanized neurofibroma model from induced pluripotent stem cells delineates tumor pathogenesis and developmental origins J Clin Invest 2020-10-27 [PMID: 33108355]
Itoyama T, Yoshida S, Tomokiyo A et al. Possible function of GDNF and Schwann cells in wound healing of periodontal tissue J. Periodont. Res. 2020-06-20 [PMID: 32562261]

Array NBP1-92714

• GAP-43 Antibodies
• GAP-43 ELISA Kits
• GAP-43 Lysate
• GAP-43 Proteins