Tyrosine Hydroxylase Antibody

The tetrameric enzyme tyrosine hydroxylase (TH), also designated as tyrosine 3-monooxygenase (TY3H), is the rate-limiting enzyme for catecholamine biosynthesis and has a theoretical molecular weight of 60 kDa. Encoded by the TH gene, TH catalyzes the conversion of the amino acid L-tyrosine to L-3,4- dihydroxyphenylalanine (L-dopa) in the central nervous system and adrenal medulla. The precursor of catecholamines, L-dopa, is converted to dopamine for use in the biosynthesis of neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline) (1) . Dysfunction in the TH gene, and thus the enzymatic activity by TH, dysregulates catecholamine synthesis.

Two transcription factor binding sites in the proximal region of the TH gene, the TPA-responsive element (TRE) and the c-AMP responsive element (CRE), have been implicated in the complex regulation of the TH gene. Dysregulation of breakdown for the amino acid, tyrosine, by TH is a result of a genetic disorder that results in Tyrosinemia (high levels of tyrosine in the blood, tissue and organs).

Tyrosine hydroxylase deficiency is a disorder that primarily affects movement, where individuals display symptoms that include lack of coordination when walking, postural tremors and unusual body positioning. TH deficient dopamine-responsive dystonia (DRD), also known as Segawa syndrome, is a rare genetic disorder that is associated with low levels of TH and is diagnosed during childhood with characteristic symptoms including increased muscle tone (dystonia) and signs of Parkinsonism like bradykinesia, tremors, rigidity and postural instability (2). Correspondingly, TH is also linked to Parkinson's disease in older adults, where low dopamine levels are a consistent neurochemical abnormality. Functional polymorphisms of the TH gene may be involved in the pathogenesis of neuropsychiatric diseases such as schizophrenia and other affective disorders where dopamine is often dysregulated (3).

References

1. Hamanaka, Y., & Mizunami, M. (2019). Tyrosine hydroxylase-immunoreactive neurons in the mushroom body of the field cricket, Gryllus bimaculatus. Cell Tissue Res, 376(1), 97-111. doi:10.1007/s00441-018-2969-9

2. Li, L., & Zhou, F. M. (2013). Parallel dopamine D1 receptor activity dependence of l-Dopa-induced normal movement and dyskinesia in mice. Neuroscience, 236, 66-76. doi:10.1016/j.neuroscience.2012.12.065

3. Borkar, C. D., Bharne, A. P., Nagalakshmi, B., Sakharkar, A. J., Subhedar, N. K., & Kokare, D. M. (2018). Cocaine- and Amphetamine-Regulated Transcript Peptide (CART) Alleviates MK-801-Induced Schizophrenic Dementia-Like Symptoms. Neuroscience, 375, 94-107. doi:10.1016/j.neuroscience.2018.01.056

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 6 confirmed species: Human, Mouse, Rat, Chicken, Drosophila, Insect.

We have publications tested in 13 applications: B/N, Dual ISH-IHC, ICC/IF, IF/ICC, IF/IHC, IHC, IHC-F, IHC-Fr, IHC-FrFl, IHC-P, IHC-WhMt, ISH, WB.

Showing Publications 1 - 10 of 219. Show All 219 Publications. Collapse Publications.

Publications using NB300-109	Applications	Species
Zheng X, Liu Z, He Z et al. Preclinical Long-Term Safety of Intraspinal Transplantation of Human Dorsal Spinal GABA Neural Progenitor Cells iScience 2023-10-01 [PMID: 38026209]
Grembecka B, Majkutewicz I, Harackiewicz O, Wrona D Deep-Brain Subthalamic Nucleus Stimulation Enhances Food-Related Motivation by Influencing Neuroinflammation and Anxiety Levels in a Rat Model of Early-Stage Parkinson’s Disease International Journal of Molecular Sciences 2023-11-29 [PMID: 38069238] (IHC, Rat) Details: Dilution 1:1500	IHC	Rat
Cara-Esteban M, Marín MP, Martínez-Alonso E et al. The Golgi complex of dopaminergic enteric neurons is fragmented in a hemiparkinsonian rat model Microscopy research and technique 2023-10-19 [PMID: 37855309] (IF/ICC, Rat)	IF/ICC	Rat
Otani Y, Yoshikawa S, Nagao K et al. Connective tissue mast cells store and release noradrenaline The journal of physiological sciences : JPS 2023-10-12 [PMID: 37828465] (WB, Mouse)	WB	Mouse
Otero MG, Bell S, Laperle AH et al. Organ-Chips Enhance the Maturation of Human iPSC-Derived Dopamine Neurons Int J Mol Sci 2023-09-18 [PMID: 37762529] (ICC/IF)	ICC/IF
Puelles L, Stühmer T, Rubenstein JLR, Diaz C Critical test of the assumption that the hypothalamic entopeduncular nucleus of rodents is homologous with the primate internal pallidum The Journal of comparative neurology 2023-11-01 [PMID: 37695031] (IHC, Mouse)	IHC	Mouse
Suzuki T, Hattori S, Mizukami H et al. Inversed Effects of Nav1.2 Deficiency at Medial Prefrontal Cortex and Ventral Tegmental Area for Prepulse Inhibition in Acoustic Startle Response Molecular neurobiology 2023-08-31 [PMID: 37650965]
Chen X, Tsika E, Levine N, Moore DJ. VPS35 and ?-Synuclein fail to interact to modulate neurodegeneration in rodent models of Parkinson's disease Molecular Neurodegeneration 2023-08-04 [PMID: 37542299] (WB)	WB
He B, Gao R, Lv S et al. Cancer cell employs a microenvironmental neural signal trans-activating nucleus-mitochondria coordination to acquire stemness Signal transduction and targeted therapy 2023-07-19 [PMID: 37463926] (ICC/IF, Human)	ICC/IF	Human
Marcinkiewcz C, Wang R, Khan K et al. Alcohol inhibits sociability via serotonin inputs to the nucleus accumbens Research Square 2023-08-18 [PMID: 37461716]
Liu Q, Zhu D, Li N et al. Regulation of LRRK2 mRNA stability by ATIC and its substrate AICAR through ARE-mediated mRNA decay in Parkinson's disease The EMBO journal 2023-06-27 [PMID: 37366237]
Kim MS, Ra EA, Kweon SH et al. Advanced human iPSC-based preclinical model for Parkinson's disease with optogenetic alpha-synuclein aggregation Cell stem cell 2023-06-09 [PMID: 37339636]
Tabata, H;Mori, D;Matsuki, T;Yoshizaki, K;Asai, M;Nakayama, A;Ozaki, N;Nagata, KI; Histological Analysis of a Mouse Model of the 22q11.2 Microdeletion Syndrome Biomolecules 2023-04-27 [PMID: 37238632] (ICC/IF, Mouse)	ICC/IF	Mouse
Mahoney-Rafferty EC, Tucker HR, Akhtar K et al. Assessing the Location, Relative Expression and Subclass of Dopamine Receptors in the Cerebellum of Hemi-Parkinsonian Rats Neuroscience 2023-04-26 [PMID: 37116741]
Khan KM, Balasubramanian N, Gaudencio G et al. Human tau-overexpressing mice recapitulate brainstem involvement and neuropsychiatric features of early Alzheimer's disease Acta neuropathologica communications 2023-04-03 [PMID: 37009893] (IHC, Mouse)	IHC	Mouse
Villadiego J, Garc�a-Swinburn R, Garc�a-Gonz�lez D et al. Extracellular matrix protein anosmin-1 overexpression alters dopaminergic phenotype in the CNS and the PNS with no pathogenic consequences in a MPTP model of Parkinson's disease Brain Structure and Function 2023-03-30 [PMID: 36995433] (ICC/IF)	ICC/IF
Villadiego J, Mu�oz-Manchado AB, Sobrino V et al. Protection and Repair of the Nigrostriatal Pathway with Stem-Cell-Derived Carotid Body Glomus Cell Transplants in Chronic MPTP Parkinsonian Model International journal of molecular sciences 2023-03-14 [PMID: 36982650] (IHC, Mouse)	IHC	Mouse
Jim�nez-G�mez B, Ortega-S�enz P, Gao L et al. Transgenic NADH dehydrogenase restores oxygen regulation of breathing in mitochondrial complex I-deficient mice Nature communications 2023-03-01 [PMID: 36859533] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Kim H, Huh YJ, Kim JH et al. Identification and evaluation of midbrain specific longevity-related genes in exceptionally long-lived but healthy mice Frontiers in Aging Neuroscience 2023-01-11 [PMID: 36711211] (IHC, WB)	IHC, WB
Lambertos A, NuNez-Sanchez M, LOpez-GarcIa C et al. Antizyme Inhibitor 2-Deficient Mice Exhibit Altered Brain Polyamine Levels and Reduced Locomotor Activity Biomolecules 2022-12-21 [PMID: 36671399] (IHC-Fr, Mouse) Details: Mouse brain sections, dilution used 1:1000	IHC-Fr	Mouse
L�pez-Gonz�lez L, Mart�nez-de-la-Torre M, Puelles L. Populational heterogeneity and partial migratory origin of the ventromedial hypothalamic nucleus: genoarchitectonic analysis in the mouse Brain Structure and Function 2023-01-04 [PMID: 36598560] (ICC/IF, IHC)	ICC/IF, IHC
Saenz J, Yao O, Khezerlou E et al. Cocaine-regulated trafficking of dopamine transporters in cultured neurons revealed by a pH sensitive reporter iScience 2023-01-20 [PMID: 36594015]
Saenz J, Yao O, Khezerlou E et al. Cocaine-regulated trafficking of dopamine transporters in cultured neurons revealed by a pH sensitive reporter iScience 2023-01-20 [PMID: 36594015]
Anderson KA, Whitehead BJ, Petersen ED et al. Behavioral Context Improves Optogenetic Stimulation of Transplanted Dopaminergic Cells in Unilateral 6-OHDA Rats Behavioural brain research 2022-12-28 [PMID: 36586489] (IF/IHC, Rat)	IF/IHC	Rat
Lee B, Ines I, Je J et al. Effect of Renal Ischemia Reperfusion on Brain Neuroinflammation Biomedicines 2022-11-21 [PMID: 36428560] (IHC-Fr, WB, Mouse)	IHC-Fr, WB	Mouse
Rahmani Z, Surabhi S, Rojo-CortEs F et al. Lamp1 Deficiency Enhances Sensitivity to a-Synuclein and Oxidative Stress in Drosophila Models of Parkinson Disease International Journal of Molecular Sciences 2022-10-28 [PMID: 36361864] (IHC-WhMt, Drosophila)	IHC-WhMt	Drosophila
Diaz C, de la Torre MM, Rubenstein JLR, Puelles L Dorsoventral Arrangement of Lateral Hypothalamus Populations in the Mouse Hypothalamus: a Prosomeric Genoarchitectonic Analysis Molecular neurobiology 2022-11-11 [PMID: 36357614] (IF/IHC, Mouse) Details: Dilution used in IHC 1:1000	IF/IHC	Mouse
Lauritano A, Cipollone I, Verde R et al. The endocannabinoidome mediator N-oleoylglycine is a novel protective agent against 1-methyl-4-phenyl-pyridinium-induced neurotoxicity Frontiers in Aging Neuroscience 2022-10-14 [PMID: 36313013] (B/N, WB)	B/N, WB
Scott L, Karuppagounder SS, Neifert S et al. The absence of Parkin does not promote dopamine or mitochondrial dysfunction in PolgAD257A/D257A mitochondrial mutator mice The Journal of neuroscience : the official journal of the Society for Neuroscience 2022-10-24 [PMID: 36280265]
Ryu TH, Subramanian M, Yeom E, Yu K. The prominin-like Gene Expressed in a Subset of Dopaminergic Neurons Regulates Locomotion in Drosophila Molecules and Cells 2022-09-30 [PMID: 35993164] (IHC)	IHC
Kim H, Maeng HJ, Kim JH et al. Synthetic Peucedanocoumarin IV Prevents alpha-Synuclein Neurotoxicity in an Animal Model of Parkinson's Disease International journal of molecular sciences 2022-08-03 [PMID: 35955753] (IHC-Fr, Mouse) Details: Dilution used 1:1000	IHC-Fr	Mouse
Panicker N, Kam TI, Wang H et al. Neuronal NLRP3 is a parkin substrate that drives neurodegeneration in Parkinson's disease Neuron 2022-05-25 [PMID: 35654037] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Bilbao MG, Garrigos D, Martinez-Morga M et al. Prosomeric Hypothalamic Distribution of Tyrosine Hydroxylase Positive Cells in Adolescent Rats Frontiers in Neuroanatomy 2022-05-06 [PMID: 35601999] (IHC, WB)	IHC, WB
Fern�ndez B, Chittoor-Vinod VG, Kluss JH et al. Evaluation of Current Methods to Detect Cellular Leucine-Rich Repeat Kinase 2 (LRRK2) Kinase Activity Journal of Parkinson's Disease 2022-07-08 [PMID: 35599495] (WB)	WB
Park H, Kam TI, Peng H et al. PAAN/MIF nuclease inhibition prevents neurodegeneration in Parkinson's disease Cell 2022-05-26 [PMID: 35545089] (IHC-FrFl, Mouse)	IHC-FrFl	Mouse
Hinkle JT, Patel J, Panicker N et al. STING mediates neurodegeneration and neuroinflammation in nigrostriatal alpha-synucleinopathy Proceedings of the National Academy of Sciences of the United States of America 2022-04-12 [PMID: 35394877]
Pirooznia SK, Wang H, Panicker N et al. Deubiquitinase CYLD acts as a negative regulator of dopamine neuron survival in Parkinson's disease Science advances 2022-04-01 [PMID: 35363524] (IF/IHC, Mouse)	IF/IHC	Mouse
Huang R, Gao Y, Chen J et al. TGR5 Agonist INT-777 Alleviates Inflammatory Neurodegeneration in Parkinson's Disease Mouse Model by Modulating Mitochondrial Dynamics in Microglia Neuroscience 2022-03-04 [PMID: 35257795]
Sterling JK, Kam TI, Guttha S et al. Interleukin-6 triggers toxic neuronal iron sequestration in response to pathological alpha-synuclein Cell reports 2022-02-15 [PMID: 35172141]
Lee SL, Hsu JY, Chen TC et al. Erinacine A Prevents Lipopolysaccharide-Mediated Glial Cell Activation to Protect Dopaminergic Neurons against Inflammatory Factor-Induced Cell Death In Vitro and In Vivo International journal of molecular sciences 2022-01-12 [PMID: 35054997] (WB, Rat)	WB	Rat
Tampakakis E, Gangrade H, Glavaris S et al. Heart neurons use clock genes to control myocyte proliferation Science advances 2021-12-03 [PMID: 34851661] (WB, IF/IHC, Mouse)	WB, IF/IHC	Mouse
Pant C, Chakrabarti M, Mendonza JJ Et al. Aza-Flavanone Diminishes Parkinsonism in the Drosophila melanogaster Parkin Mutant ACS chemical neuroscience 2021-12-01 [PMID: 34763419] (IHC-P, Drosophila)	IHC-P	Drosophila
Lee JS, Lee SB, Kim DW Et al. Social isolation-related depression accelerates ethanol intake via microglia-derived neuroinflammation Science advances 2021-11-05 [PMID: 34739315] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Thapa D, Valente JS, Barrett B Et al. Dysfunctional TRPM8 signalling in the vascular response to environmental cold in ageing eLife 2021-11-02 [PMID: 34726597] (WB, Mouse)	WB	Mouse
Eckardt L, Prange-Barczynska M, Hodson EJ et al. Developmental role of PHD2 in the pathogenesis of pseudohypoxic pheochromocytoma Endocrine-Related Cancer 2021-12-01 [PMID: 34658364] (IHC)	IHC
Ahmad MH, Fatima M, Ali M Et al. Naringenin alleviates paraquat-induced dopaminergic neuronal loss in SH-SY5Y cells and a rat model of Parkinson's disease Neuropharmacology 2021-10-13 [PMID: 34655599] (WB, IF/IHC, Rat)	WB, IF/IHC	Rat
Seo BA, Kim D, Hwang H Et al. TRIP12 ubiquitination of glucocerebrosidase contributes to neurodegeneration in Parkinson's disease Neuron 2021-10-04 [PMID: 34644545]
Kwon SH, Kim S, Park AY Et al. A Novel, Selective c-Abl Inhibitor, Compound 5, Prevents Neurodegeneration in Parkinson's Disease Journal of medicinal chemistry 2021-10-28 [PMID: 34583507]
Kim H, Shin JY, Jo A Et al. Parkin interacting substrate phosphorylation by c-Abl drives dopaminergic neurodegeneration Brain : a journal of neurology 2021-09-28 [PMID: 34581802] (IHC-P, Human)	IHC-P	Human
Kang JY, Kim DY, Lee JS et al. Korean Red Ginseng Ameliorates Fatigue via Modulation of 5-HT and Corticosterone in a Sleep-Deprived Mouse Model Nutrients 2021-09-06 [PMID: 34578998] (ICC/IF)	ICC/IF
Kasemeier-Kulesa JC, Spengler JA, Muolo CE Et al. The embryonic trunk neural crest microenvironment regulates the plasticity and invasion of human neuroblastoma via TrkB signaling Developmental biology 2021-08-17 [PMID: 34416224] (IF/IHC, Chicken)	IF/IHC	Chicken
Sunardi M, Ito K, Enomoto H Live visualization of a functional RET-EGFP chimeric receptor in homozygous knock-in mice Development, growth & differentiation 2021-08-01 [PMID: 34324195] (ICC/IF, Mouse)	ICC/IF	Mouse
Zhang, Gf, Chen Sr, Jin D et Al. alpha 2 delta-1 Upregulation in Primary Sensory Neurons Promotes NMDA Receptor-Mediated Glutamatergic Input in Resiniferatoxin-Induced Neuropathy The Journal of neuroscience : the official journal of the Society for Neuroscience 2021-07-07 [PMID: 34252037]
Xie J, Chen S, Bopassa JC, Banerjee S. Drosophila tubulin polymerization promoting protein mutants reveal pathological correlates relevant to human Parkinson's disease Scientific Reports 2021-06-30 [PMID: 34193896] (IHC)	IHC
Sugino S, Konno D, Abe J et al. Crucial involvement of catecholamine neurotransmission in postoperative nausea and vomiting: Whole-transcriptome profiling in the rat nucleus of the solitary tract Genes, brain, and behavior 2021-06-10 [PMID: 34114352]
Lee J, Kim H, Jo A et al. alpha-Synuclein A53T Binds to Transcriptional Adapter 2-Alpha and Blocks Histone H3 Acetylation International Journal of Molecular Sciences 2021-05-20 [PMID: 34065515] (IF/IHC, Mouse)	IF/IHC	Mouse
Yamane M, Takaoka N, Obara K et al. Hair-Follicle-Associated Pluripotent (HAP) Stem Cells Can Extensively Differentiate to Tyrosine-Hydroxylase-Expressing Dopamine-Secreting Neurons Cells 2021-04-10 [PMID: 33920157] (ICC/IF, Mouse)	ICC/IF	Mouse
Bechmann N, Watts D, Steenblock C et al. Adrenal Hormone Interactions and Metabolism: A Single Sample Multi-Omics Approach Hormone and Metabolic Research 2021-05-01 [PMID: 33902135] (WB)	WB
Johnston K, Pachnis P, Tasdogan A et al. Isotope tracing reveals glycolysis and oxidative metabolism in childhood tumors of multiple histologies Med (N Y) 2021-04-16 [PMID: 33860280]
Bov� M, Monto F, Guillem-Llobat P et al. NT3/TrkC Pathway Modulates the Expression of UCP-1 and Adipocyte Size in Human and Rodent Adipose Tissue Front Endocrinol (Lausanne) 2021-03-18 [PMID: 33815288]
Ludwig MQ, Cheng W, Gordian D et al. A genetic map of the mouse dorsal vagal complex and its role in obesity Nature metabolism 2021-03-25 [PMID: 33767443] (ICC/IF)	ICC/IF
Viventi S, Frausin S, Howden SE et al. In vivo survival and differentiation of Friedreich ataxia iPSC-derived sensory neurons transplanted in the adult dorsal root ganglia Stem cells translational medicine 2021-03-18 [PMID: 33734599]
Jin JW, Fan X, Del Cid-Pellitero E et al. Development of an alpha-synuclein knockdown peptide and evaluation of its efficacy in Parkinson's disease models Communications biology 2021-02-19 [PMID: 33608634] (ICC/IF, Rat)	ICC/IF	Rat
Kim H, Park J, Kang H et al. Activation of the Akt1-CREB pathway promotes RNF146 expression to inhibit PARP1-mediated neuronal death Science Signaling 2020-12-22 [PMID: 33443209]
Yan J, Huang J, Liu A et al. Atorvastatin improves motor function, anxiety and depression by NOX2-mediated autophagy and oxidative stress in MPTP-lesioned mice Aging (Albany NY) 2021-01-15 [PMID: 33289703] (IHC)	IHC
Vanan, S, Zeng, X Et al. Altered striatal dopamine levels in Parkinson's disease VPS35 D620N mutant transgenic aged mice. Mol Brain 2020-12-01 [PMID: 33261640] (WB, Mouse)	WB	Mouse
Giannoccaro MP, Donadio V, Giannini G et al. Comparison of 123I-MIBG scintigraphy and phosphorylated alpha-synuclein skin deposits in synucleinopathies Parkinsonism Relat Disord 2020-10-08 [PMID: 33049589] (IHC-FrFl, Human)	IHC-FrFl	Human
Brundl M, Garreis F, Schicht M et al. Characterization of the innervation of the meibomian glands in humans, rats and mice Ann Anat 2020-10-04 [PMID: 33027687] (ICC/IF, Human)	ICC/IF	Human
Macias D, Moore S, Crosby A et al. Targeting HIF2 alpha-ARNT hetero-dimerisation as a novel therapeutic strategy for pulmonary arterial hypertension The European respiratory journal 2021-03-01 [PMID: 32972983] (IF/IHC, Rat)	IF/IHC	Rat
Wang H, Dou S, Zhu J et al. Ghrelin mitigates MPP+-induced cytotoxicity: Involvement of ERK1/2-mediated Nrf2/HO-1 and endoplasmic reticulum stress PERK signaling pathway Peptides 2020-08-16 [PMID: 32814076] (WB, Human)	WB	Human
Son Y, Jeong YJ, Shin NR et al. Inhibition of Colony-Stimulating Factor 1 Receptor by PLX3397 Prevents Amyloid Beta Pathology and Rescues Dopaminergic Signaling in Aging 5xFAD Mice Int J Mol Sci 2020-08-03 [PMID: 32756440] (IHC-P, Human)	IHC-P	Human
Wang H, Dou S, Zhu J et al. Ghrelin protects dopaminergic neurons against MPTP neurotoxicity through promoting autophagy and inhibiting endoplasmic reticulum mediated apoptosis Brain Res 2020-07-26 [PMID: 32710901] (WB, IHC-Fr, Mouse)	WB, IHC-Fr	Mouse
Garcia-Calero E, MartInez-de-la-Torre M, Puelles L A radial histogenetic model of the mouse pallial amygdala Brain Struct Funct 2020-06-24 [PMID: 32583144] (IF/IHC, Mouse)	IF/IHC	Mouse
Donadio, V, Incensi, A Et al. Skin Biopsy May Help to Distinguish Multiple System Atrophy-Parkinsonism from Parkinson's Disease With Orthostatic Hypotension. Mov Disord 2020-09-01 [PMID: 32557839] (IF/IHC, Human)	IF/IHC	Human
Puelles, L, DIaz, C Et al. LacZ-reporter mapping of Dlx5/6 expression and genoarchitectural analysis of the postnatal mouse prethalamus. J Comp Neurol 2021-02-01 [PMID: 32420617] (WB, Rat)	WB	Rat
Wu D, Fan Y, Liu S et al. Loading-induced antitumor capability of murine and human urine FASEB J. 2020-04-15 [PMID: 32293076] (WB, Mouse)	WB	Mouse
Davis R B, Ding S et al. Calcitonin-Receptor-Like Receptor Signaling Governs Intestinal Lymphatic Innervation and Lipid Uptake. ACS Pharmacol Transl Sci 2019-12-04 [PMID: 32219216] (IF/IHC, Mouse)	IF/IHC	Mouse
Fatima M, Ahmad Mh, Srivastav S et Al. A Selective D2 Dopamine receptor agonist alleviates depression through up-regulation of tyrosine hydroxylase and increased neurogenesis in hippocampus of the prenatally stressed rats Neurochem. Int. 2020-03-19 [PMID: 32201282] (WB, Rat)	WB	Rat
Cheng W, Ndoka E, Hutch Cr et Al. Leptin receptor-expressing Nucleus Tractus Solitarius neurons suppress food intake independently of GLP1 in mice JCI Insight 2020-03-17 [PMID: 32182221] (IF/IHC, IHC-F, Mouse)	IF/IHC, IHC-F	Mouse
Lyu Q, Zheng H S et al. Microwaving and Fluorophore-Tyramide for Multiplex Immunostaining on Mouse Adrenals - Using Unconjugated Primary Antibodies from the Same Host Species. J Vis Exp 2020-02-21 [PMID: 32150172] (IF/IHC, Mouse)	IF/IHC	Mouse
Yan J, Liu A, Fan H Et Al. Simvastatin Improves Behavioral Disorders and Hippocampal Inflammatory Reaction by NMDA-Mediated Anti-inflammatory Function in MPTP-Treated Mice Cell. Mol. Neurobiol. 2020-02-03 [PMID: 32016638] (IHC-F, Mouse)	IHC-F	Mouse
Cheng X, Prange-Barczynska M, Fielding JW et al. Marked and rapid effects of pharmacological HIF-2 alpha antagonism on hypoxic ventilatory control J. Clin. Invest. 2020-01-30 [PMID: 31999648] (ISH, IHC-P, Mouse)	ISH, IHC-P	Mouse
Cheng W, Gonzalez I, Pan W et al. Calcitonin Receptor Neurons in the Mouse Nucleus Tractus Solitarius Control Energy Balance via the Non-aversive Suppression of Feeding Cell Metab. 2020-01-10 [PMID: 31955990]
Moreno-Domnguez A, Ortega-Saenz P, Gao L et al. Acute O2 sensing through HIF2 alpha-dependent expression of atypical cytochrome oxidase subunits in arterial chemoreceptors. Sci Signal. 2020-01-21 [PMID: 31848220] (IF/IHC, Mouse)	IF/IHC	Mouse
Weinberg RP, Koledova VV, Subramaniam A et al. Palm Fruit Bioactives augment expression of Tyrosine Hydroxylase in the Nile Grass Rat basal ganglia and alter the colonic microbiome Sci Rep 2019-12-09 [PMID: 31819070] (IHC-P, Rat)	IHC-P	Rat
Mouchiroud M, Camire E., Aldow M et al. The Hepatokine TSK does not affect brown fat thermogenic capacity, body weight gain, and glucose homeostasis. Mol Metab. 2019-12-01 [PMID: 31767170] (WB, Mouse)	WB	Mouse
Donadio V, Incensi A, Vacchiano V et al. The autonomic innervation of hairy skin in humans: an in vivo confocal study Sci Rep 2019-11-18 [PMID: 31740757] (ICC/IF, Human)	ICC/IF	Human
Mouchiroud M, Camire E, Aldow M et al. The hepatokine Tsukushi is released in response to NAFLD and impacts cholesterol homeostasis JCI Insight 2019-08-08 [PMID: 31391339] (WB, Mouse, Human)	WB	Mouse, Human
Kamiya A, Hayama Y, Kato S et al. Genetic manipulation of autonomic nerve fiber innervation and activity and its effect on breast cancer progression Nat. Neurosci. 2019-08-01 [PMID: 31285612] (IF/IHC, Mouse, Rat)	IF/IHC	Mouse, Rat
El-Desouky S, Taalab YM, El-Gamal M et al. Animal Model for Leigh Syndrome Methods Mol. Biol. 2019-07-06 [PMID: 31273716] (Human)		Human
Kim S, Kwon SH, Kam TI et al. Transneuronal Propagation of Pathologic alpha-Synuclein from the Gut to the Brain Models Parkinson's Disease Neuron 2019-06-17 [PMID: 31255487] (Mouse)		Mouse
Alekseyenko OV, Chan YB, Okaty BW et al. Serotonergic Modulation of Aggression in Drosophila Involves GABAergic and Cholinergic Opposing Pathways Curr. Biol. 2019-06-18 [PMID: 31231050]
Adamska A, Ferro R, Lattanzio R et al. Impact of Extrinsic and Intrinsic Hypoxia on Catecholamine Biosynthesis in Absence or Presence of Hif2-alpha in Pheochromocytoma Cells Cancers (Basel) 2019-04-28 [PMID: 31035382] (IHC-P, WB, Mouse)	IHC-P, WB	Mouse
Kim, H;Park, J;Leem, H;Cho, M;Yoon, JH;Maeng, HJ;Lee, Y; Rhododendrin-Induced RNF146 Expression via Estrogen Receptor beta Activation is Cytoprotective Against 6-OHDA-Induced Oxidative Stress Int J Mol Sci 2019-04-10 [PMID: 30974833] (ICC/IF, Human)	ICC/IF	Human
Thayer, JA;Awad, O;Hegdekar, N;Sarkar, C;Tesfay, H;Burt, C;Zeng, X;Feldman, RA;Lipinski, MM; The PARK10 gene USP24 is a negative regulator of autophagy and ULK1 protein stability Autophagy 2019-04-07 [PMID: 30957634] (ICC/IF, Human)	ICC/IF	Human
Chen X, Kordich JK, Williams ET et al. Parkinson's disease-linked D620N VPS35 knockin mice manifest tau neuropathology and dopaminergic neurodegeneration Proc. Natl. Acad. Sci. U.S.A. 2019-03-19 [PMID: 30842285] (IF/IHC, Mouse)	IF/IHC	Mouse
Deng B, Li Q, Liu X et al. Chemoconnectomics: Mapping Chemical Transmission in Drosophila Neuron 2019-02-12 [PMID: 30799021] (IHC-WhMt, Drosophila)	IHC-WhMt	Drosophila
Maksoud E, Liao EH, Haghighi AP. A Neuron-Glial Trans-Signaling Cascade Mediates LRRK2-Induced Neurodegeneration Cell Rep 2019-02-12 [PMID: 30759389] (ICC/IF, Drosophila)	ICC/IF	Drosophila
Hajji K, Mteyrek A, Sun J et al. Neuroprotective effects of PACAP against paraquat-induced oxidative stress in the Drosophila central nervous system Hum. Mol. Genet. 2019-01-30 [PMID: 30715303] (IHC-WhMt, Drosophila)	IHC-WhMt	Drosophila
Hamanaka Y, Mizunami M. Tyrosine hydroxylase-immunoreactive neurons in the mushroom body of the field cricket, Gryllus bimaculatus Cell Tissue Res. 2018-12-21 [PMID: 30578444] (IF/IHC, Insect)	IF/IHC	Insect
Rinaldi F, Seguella L, Gigli S et al. inPentasomes: An innovative nose-to-brain pentamidine delivery blunts MPTP parkinsonism in mice J Control Release 2018-12-07 [PMID: 30529726] (IF/IHC, Mouse)	IF/IHC	Mouse
Kishinevsky S, Wang T, Rodina A et al. HSP90-incorporating chaperome networks as biosensor for disease-related pathways in patient-specific midbrain dopamine neurons. Nat Commun. 2018-10-19 [PMID: 30341316] (WB, Human)	WB	Human
Chang, A J, Kim, N S Et al. Chang et al. reply. Nature 2018-09-01 [PMID: 30258152] (IF/IHC, WB, Human)	IF/IHC, WB	Human
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Jois S, Chan YB, Fernandez MP, Leung AK. Characterization of the Sexually Dimorphic fruitless Neurons That Regulate Copulation Duration. Front Physiol 2018-06-25 [PMID: 29988589] (IF/IHC, Drosophila)	IF/IHC	Drosophila
kim D, Yoo JM, Hwang H et al. Graphene quantum dots prevent a-synucleinopathy in Parkinson's disease. Nat Nanotechnol. 2018-07-09 [PMID: 29988049] (IF/IHC, Mouse)	IF/IHC	Mouse
Villadiego J, Romo-Madero S, Garcia-Swinburn R et al. Long-term immunosuppression for CNS mouse xenotransplantation: Effects on nigrostriatal neurodegeneration and neuroprotective carotid body cell therapy Xenotransplantation. [PMID: 29932254] (IF/IHC, Mouse)	IF/IHC	Mouse
Bhupal PK, Anderson KA, Shall GP et al. Behavioral and neurochemical responses derived from dopaminergic intrastriatal grafts in hemiparkinsonian rats engaged in a novel motor task J. Neurosci. Methods 2018-06-17 [PMID: 29924980] (IF/IHC, Rat)	IF/IHC	Rat
Fielding JW1, Hodson EJ, Cheng X PHD2 inactivation in Type I cells drives HIF-2 alpha -dependent multilineage hyperplasia and the formation of paraganglioma-like carotid bodies. J Physiol. 2018-06-19 [PMID: 29917232] (Dual ISH-IHC, Mouse)	Dual ISH-IHC	Mouse
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Lee S, Kim S, Park Y et al. The c-Abl inhibitor, Radotinib HCl, is neuroprotective in a preclinical Parkinson's disease mouse model Hum Mol Genet. [PMID: 29897434] (IF/IHC, ICC/IF, Mouse)	IF/IHC, ICC/IF	Mouse
Williams ET, Glauser L, Tsika E et al. Parkin mediates the ubiquitination of VPS35 and modulates retromer-dependent endosomal sorting Hum. Mol. Genet. 2018-06-11 [PMID: 29893854] (Human)		Human
Johnson R, Macias D, Lopez-Barneo J et al. HIF-2a is essential for carotid body development and function eLife 2018-01-20 [PMID: 29863471] (IF/IHC, Mouse)	IF/IHC	Mouse
Je G, Guhathakurta S, Yun SP et al. A novel extended form of alpha-synuclein 3'UTR in the human brain Mol Brain 2018-05-25 [PMID: 29801501] (WB, Mouse)	WB	Mouse
Kim D, Hwang H, Choi S et al. D409H GBA1 mutation accelerates the progression of pathology in A53T a-synuclein transgenic mouse model. Acta Neuropathol Commun 2018-04-27 [PMID: 29703245] (Mouse)		Mouse
Macias D, Cowburn A. S, et al. HIF-2 alpha is essential for carotid body development and function. Elife 2018-04-19 [PMID: 29671738] (IF/IHC, Mouse)	IF/IHC	Mouse
Sun J, Xu AQ, Giraud J et al. Neural Control of Startle-Induced Locomotion by the Mushroom Bodies and Associated Neurons in Drosophila. Front Syst Neurosci 2018-03-28 [PMID: 29643770] (IF/IHC, Drosophila)	IF/IHC	Drosophila
Borkar CD, Bharne AP, Nagalakshmi B et al. Cocaine- and Amphetamine-Regulated Transcript Peptide (CART) Alleviates MK-801-Induced Schizophrenic Dementia-Like Symptoms. Neuroscience 2018-04-01 [PMID: 29425773]
Wang Y, Zhou FM. Striatal But Not Extrastriatal Dopamine Receptors Are Critical to Dopaminergic Motor Stimulation Front Pharmacol 2017-12-21 [PMID: 29311936] (IHC-FrFl, Mouse)	IHC-FrFl	Mouse
Kim S, Yun SP, Lee S et al. GBA1 deficiency negatively affects physiological A-synuclein tetramers and related multimers. Proc. Natl. Acad. Sci. U.S.A. 2018-01-23 [PMID: 29311330] (Mouse)		Mouse
Kim H, Ham S, Lee JY et al. Estrogen receptor activation contributes to RNF146 expression and neuroprotection in Parkinson's disease models Oncotarget 2017-10-11 [PMID: 29290984] (ICC/IF, Mouse)	ICC/IF	Mouse
Kang H, Jo A, Kim H et al. PARIS reprograms glucose metabolism by HIF-1a induction in dopaminergic neurodegeneration. Biochem. Biophys. Res. Commun. 2017-12-26 [PMID: 29287724] (IF/IHC, Human)	IF/IHC	Human
Awad O, Panicker LM, Deranieh RM et al. Altered Differentiation Potential of Gaucher's Disease iPSC Neuronal Progenitors due to Wnt/B-Catenin Downregulation. Stem Cell Reports 2017-12-12 [PMID: 29198828] (ICC/IF, Human)	ICC/IF	Human
Shepard R, Beckett E, Coutellier L. Assessment of the acquisition of executive function during the transition from adolescence to adulthood in male and female mice Dev Cogn Neurosci. 2017-11-02 [PMID: 29102727] (WB, Mouse)	WB	Mouse
Salama M, Elhussiny M, Magdy A et al. Dual mTORC1/mTORC2 blocker as a possible therapy for tauopathy in cellular model.. Metab Brain Dis. 2017-10-27 [PMID: 29080085] (Human)		Human
Cowburn AS, Macias D, Summers C et al. Cardiovascular adaptation to hypoxia and the role of peripheral resistance. Elife. 2017-10-19 [PMID: 29049022] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Shin H, Ma Y, Chanturiya T et al. Lipolysis in Brown Adipocytes Is Not Essential for Cold-Induced Thermogenesis in Mice. Cell Metab 2017-10-05 [PMID: 28988822] (B/N)	B/N
Chen Z C, Zhang W et al. Phosphorylation of amyloid precursor protein by mutant LRRK2 promotes AICD activity and neurotoxicity in Parkinson's disease. Sci Signal 2017-07-18 [PMID: 28720718] (WB, Mouse)	WB	Mouse
Gao L, Bonilla-Henao V, Garcia-Flores P et al. Gene expression analyses reveal metabolic specifications in acute O2 -sensing chemoreceptor cells J. Physiol. (Lond.) 2017-07-17 [PMID: 28718507] (Mouse)		Mouse
Kang H, Khang R, Ham S et al. Activation of the ATF2/CREB-PGC-1alpha pathway by metformin leads to dopaminergic neuroprotection Oncotarget 2017-07-25 [PMID: 28611284] (Human)		Human
Ramirez S, Gomez-Valades AG, Schneeberger M et al. Mitochondrial Dynamics Mediated by Mitofusin 1 Is Required for POMC Neuron Glucose-Sensing and Insulin Release Control. Cell Metab. 2017-06-06 [PMID: 28591639]
Martinez-de-la-Torre M, Lambertos A, Penafiel R, Puelles L. An exercise in brain genoarchitectonics: Analysis of AZIN2-Lacz expressing neuronal populations in the mouse hindbrain. J. Neurosci. Res. 2017-05-03 [PMID: 28467636] (Mouse)		Mouse
Annese V, Navarro-Guerrero E, Rodriguez-Prieto I, Pardal, R. Physiological Plasticity of Neural-Crest-Derived Stem Cells in the Adult Mammalian Carotid Body. Cell Report. 2017-01-01 [PMID: 28423311] (ICC/IF, IHC-P, Mouse)	ICC/IF, IHC-P	Mouse
Levin E, Andreadaki A, Gobrecht P et al. Nociceptive DRG neurons express muscle lim protein upon axonal injury. Sci Rep. 2017-04-04 [PMID: 28377582] (IF/IHC, Rat)	IF/IHC	Rat
Lai F P, Lau S T et al. Correction of Hirschsprung-Associated Mutations in Human Induced Pluripotent Stem Cells Via Clustered Regularly Interspaced Short Palindromic Repeats/Cas9, Restores Neural Crest Cell Function. Gastroenterology 2017-01-07 [PMID: 28342760] (ICC/IF, Human)	ICC/IF	Human
Shimohata A, Ishihara K, Hattori S et al. Ts1Cje Down syndrome model mice exhibit environmental stimuli-triggered locomotor hyperactivity and sociability concurrent with increased flux through central dopamine and serotonin metabolism. Exp. Neurol. 2017-03-20 [PMID: 28336394] (IF/IHC, Mouse)	IF/IHC	Mouse
Xiong Y, Neifert S, Karuppagounder SS et al. Overexpression of Parkinson's Disease-Associated Mutation LRRK2 G2019S in Mouse Forebrain Induces Behavioral Deficits and a-Synuclein Pathology. eNeuro. 2017-03-21 [PMID: 28321439] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Kim JL, La Gamma EF, Estabrook T et al. Whole genome expression profiling associates activation of unfolded protein response with impaired production and release of epinephrine after recurrent hypoglycemia. PLoS ONE. 2017-02-24 [PMID: 28234964] (WB, Rat)	WB	Rat
Ishizu N, Yui D et al. Impaired striatal dopamine release in homozygous Vps35 D620N knock-in mice. Hum Mol Genet 2016-08-25 [PMID: 28173004] (WB, Mouse)	WB	Mouse
Jiang H, Kang SU, Zhang S et al. Adult Conditional Knockout of PGC-1alpha Leads to Loss of Dopamine Neurons. eneuro. 2016-08-16 [PMID: 27622213] (IF/IHC, Mouse)	IF/IHC	Mouse
Ishizu N, Yui D, Hebisawa A et al. Impaired striatal dopamine release in homozygous Vps35 D620N knock-in mice. Hum Mol Genet 2016-08-25 [PMID: 27562021]
Javed Hayate, Azimullah Sheikh, Abul Khair Salema B et al. Neuroprotective effect of nerolidol against neuroinflammation and oxidative stress induced by rotenone. BMC Neurosci 2016-01-01 [PMID: 27549180] (IF/IHC, Rat)	IF/IHC	Rat
Hamanaka Y, Minoura R, Nishino H et al. Dopamine- and Tyrosine Hydroxylase-Immunoreactive Neurons in the Brain of the American Cockroach, Periplaneta americana. PLoS ONE. 2016-08-06 [PMID: 27494326] (IF/IHC, WB, ICC/IF, Insect)	IF/IHC, WB, ICC/IF	Insect
Grier BD, Belluscio L, Cheetham CE. Olfactory Sensory Activity Modulates Microglial-Neuronal Interactions during Dopaminergic Cell Loss in the Olfactory Bulb. Front Cell Neurosci 2016-07-15 [PMID: 27471450] (IF/IHC)	IF/IHC
Januchowski R, Wojtowicz K, Sterzynska K et al. Inhibition of ALDH1A1 activity decreases expression of drug transporters and reduces chemotherapy resistance in ovarian cancer cell lines Int. J. Biochem. Cell Biol. 2016-07-19 [PMID: 27443528] (IF/IHC, Mouse)	IF/IHC	Mouse
Cowburn AS, Crosby A, Macias D et al. HIF2 alpha -arginase axis is essential for the development of pulmonary hypertension Proc. Natl. Acad. Sci. U.S.A. 2016-08-02 [PMID: 27432976] (ICC/IF)	ICC/IF
Kniewallner KM, Wenzel D, Humpel C. Thiazine Red(+) platelet inclusions in Cerebral Blood Vessels are first signs in an Alzheimer's Disease mouse model Sci Rep 2016-06-27 [PMID: 27345467]
Ahuja M, Ammal Kaidery N, Yang L et al. Distinct Nrf2 Signaling Mechanisms of Fumaric Acid Esters and Their Role in Neuroprotection against 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Experimental Parkinson's-Like Disease. J. Neurosci. 2016-06-08 [PMID: 27277809] (IF/IHC, Mouse)	IF/IHC	Mouse
Lin CY, Hsieh HY, Chen CM et al. Non-invasive, Neuron-Specific Gene Therapy by Focused Ultrasound-Induced Blood-Brain Barrier Opening in Parkinson's Disease Mouse Model. J Control Release. 2016-05-25 [PMID: 27235980] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Xue X, Yang JY, He Y et al. Aggregated single-walled carbon nanotubes attenuate the behavioural and neurochemical effects of methamphetamine in mice. Nat Nanotechnol 2016-01-01 [PMID: 26974957] (WB, Mouse)	WB	Mouse
Perry AN, Carter CS, Cushing BS. Chronic social isolation enhances reproduction in the monogamous prairie vole (Microtus ochrogaster) Psychoneuroendocrinology 2016-02-22 [PMID: 26939085] (IHC-FrFl)	IHC-FrFl
Karuppagounder SS, Xiong Y, Lee Y et al. LRRK2 G2019S transgenic mice display increased susceptibility to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-mediated neurotoxicity. J. Chem. Neuroanat. 2016-01-22 [PMID: 26808467] (IHC-FrFl, Mouse)	IHC-FrFl	Mouse
van der Keylen P, Garreis F, Steigleder R et al. Involvement of catecholaminergic neurons in motor innervation of striated muscle in the mouse esophagus. Histochem. Cell Biol. 2016-01-21 [PMID: 26794326]
Bains M, Roberts JL. Estrogen protects against dopamine neuron toxicity in primary mesencephalic cultures through an indirect P13K/Akt mediated astrocyte pathway. Neurosci. Lett. 2015-10-28 [PMID: 26520464] (ICC/IF, Mouse)	ICC/IF	Mouse
Stevens DA, Lee Y, Kang HC et al. Parkin loss leads to PARIS-dependent declines in mitochondrial mass and respiration. Proc. Natl. Acad. Sci. U.S.A. 2015-09-15 [PMID: 26324925] (WB, ICC/IF, IHC-FrFl, Mouse)	WB, ICC/IF, IHC-FrFl	Mouse
Liu W, Li Y, Jalewa J et al. Neuroprotective effects of an oxyntomodulin analogue in the MPTP mouse model of Parkinson's disease. Eur. J. Pharmacol. 2015-08-21 [PMID: 26302060] (IHC-P, Mouse) Details: Tyrosine Hydroxylase antibody was used for IHC-P on paraffin coronal sections of brains from adult Male C57BL/6 mice subjected or not to induction of Parkinson's disease with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine/MPTP followed by treatment with d-Ser2-oxyntomodulin/Oxy, a protease resistant oxyntomodulin analogue developed to treat diabetes (Fig. 5).	IHC-P	Mouse
Kuo SY, Wu CL, Hsieh MY et al. PPL2ab neurons restore sexual responses in aged Drosophila males through dopamine Nat Commun 2015-06-30 [PMID: 26123524] (IHC-WhMt, Drosophila) Details: Tyrosine Hydroxylase antibody was used for IHC on whole-mount sections of adult drosophila brain tissues and the assay involved : 4% paraformaldehyde fixation, penetration/blocking using buffer containing 2% Triton X-100, 0.02% NaN3, 10% normal goat serum in PBS, use of anti-tyrosine hydroxylase antibody at 1:1000 dilution, detection via biotin-conjugated goat anti-rabbit secondary antibody and Alexa Fluor streptavidin.	IHC-WhMt	Drosophila
Li L, Sagot B, Zhou FM. Similar l-dopa-stimulated motor activity in mice with adult-onset 6-hydroxydopamine-induced symmetric dopamine denervation and in transcription factor Pitx3 null mice with perinatal-onset symmetric dopamine denervation. Brain Res. 2015-05-07 [PMID: 25960345] (Mouse) Details: Tyrosine Hydroxylase antibody used for IHC on mouse brain free-floating sections at a dilution of 1:1,000 (Fig 1B).		Mouse
Tsika E, Nguyen AP, Dusonchet J et al. Adenoviral-mediated expression of G2019S LRRK2 induces striatal pathology in a kinase-dependent manner in a rat model of Parkinson's disease Neurobiol. Dis. 2015-02-28 [PMID: 25731749] (IHC-FrFl, WB, Rat)	IHC-FrFl, WB	Rat
Song L, Cortopassi G. Mitochondrial complex I defects increase ubiquitin in substantia nigra. Brain Res. 2015-01-12 [PMID: 25446449]
Tsika E, Kannan M, Foo CS et al. Conditional expression of Parkinson's disease-related R1441C LRRK2 in midbrain dopaminergic neurons of mice causes nuclear abnormalities without neurodegeneration. Neurobiol Dis 2014-11-01 [PMID: 25174890] (WB)	WB
Grunewald A, Lax NZ, Rocha MC et al. Quantitative quadruple-label immunofluorescence of mitochondrial and cytoplasmic proteins in single neurons from human midbrain tissue. J Neurosci Methods. 2014-07-30 [PMID: 24880043]
Tsika E, Glauser L, Moser R et al. Parkinson's Disease-Linked Mutations in VPS35 Induce Dopaminergic Neurodegeneration. Hum. Mol. Genet. 2014-04-15 [PMID: 24740878] (WB, ICC/IF, Rat)	WB, ICC/IF	Rat
Platero-Luengo A, Gonzalez-Granero S, Duran R et al. An O2-sensitive glomus cell-stem cell synapse induces carotid body growth in chronic hypoxia. Cell 2014-01-16 [PMID: 24439383] (IHC-Fr, Rat, Mouse)	IHC-Fr	Rat, Mouse
Ortega-Saenz P, Pardal R, Levitsky K et al. Cellular properties and chemosensory responses of the Human carotid body. J Physiol. 2013-10-28 [PMID: 24167224] (IHC-Fr, ICC/IF, Human)	IHC-Fr, ICC/IF	Human
Johansson JU, Pradhan S, Lokteva LA et al. Suppression of Inflammation with Conditional Deletion of the Prostaglandin E2 EP2 Receptor in Macrophages and Brain Microglia. J Neurosci. 2013-10-02 [PMID: 24089506] (ICC/IF, IF/IHC, Mouse)	ICC/IF, IF/IHC	Mouse
Lee Y, Karuppagounder SS, Shin JH et al. Parthanatos mediates AIMP2-activated age-dependent dopaminergic neuronal loss. Nat Neurosci. 2013-08-25 [PMID: 23974709] (ICC/IF, IHC-Fr, Mouse)	ICC/IF, IHC-Fr	Mouse
Wei W, Li L, Yu G et al. Supersensitive presynaptic dopamine D2 receptor inhibition of the striatopallidal projection in nigrostriatal dopamine-deficient mice. J Neurophysiol. 2013-11-01 [PMID: 23945778] (ICC/IF, IF/IHC, Mouse)	ICC/IF, IF/IHC	Mouse
Palin EJ, Paetau A, Suomalainen A. Mesencephalic complex I deficiency does not correlate with parkinsonism in mitochondrial DNA maintenance disorders. Brain 2013-08-01 [PMID: 23811324] (IHC-P, Human)	IHC-P	Human
Gao L, Hidalgo-Figueroa M, Escudero LM et al. Age-Mediated Transcriptomic Changes in Adult Mouse Substantia Nigra. PLoS One 2013-04-30 [PMID: 23638090] (IF/IHC, Mouse)	IF/IHC	Mouse
Tzoulis C, Tran GT, Schwarzlmuller T et al. Severe nigrostriatal degeneration without clinical parkinsonism in patients with polymerase gamma mutations. Brain. 2013-08-01 [PMID: 23625061]
Alekseyenko OV, Chan YB, Li R, Kravitz EA. Single dopaminergic neurons that modulate aggression in Drosophila Proc Natl Acad Sci U S A 2013-04-09 [PMID: 23530210] (ICC/IF, Drosophila)	ICC/IF	Drosophila
Ahmad AS, Maruyama T, Narumiya S et al. PGE2 EP1 receptor deletion attenuates 6-OHDA-induced Parkinsonism in mice: old switch, new target. Neurotox Res. 2013-04-01 [PMID: 23385625] (Mouse)		Mouse
Li L, Zhou FM. Parallel dopamine D1 receptor activity dependence of L-dopa-induced normal movement and dyskinesia in mice. Neuroscience 2013-01-25 [PMID: 23357114] (ICC/IF, Mouse)	ICC/IF	Mouse
Amschl D, Neddens J, Havas D et al. Time course and progression of wild type alpha-Synuclein accumulation in a transgenic mouse model BMC Neurosci 2013-01-09 [PMID: 23302418] (IF/IHC, ICC/IF, Mouse)	IF/IHC, ICC/IF	Mouse
Bergua A, Kapsreiter M, Neuhuber WL et al. Innervation pattern of the preocular human central retinal artery Exp Eye Res 2012-12-06 [PMID: 23220730] (ICC/IF, IF/IHC, Human)	ICC/IF, IF/IHC	Human
Ahmed I, Liang Y, Schools S et al. Development and characterization of a new Parkinson's disease model resulting from impaired autophagy J Neurosci 2012-11-14 [PMID: 23152632] (ICC/IF, IF/IHC, Mouse)	ICC/IF, IF/IHC	Mouse
Munoz-Manchado AB, Villadiego J, Suarez-Luna N et al. Neuroprotective and reparative effects of carotid body grafts in a chronic MPTP model of Parkinson's disease Neurobiol Aging 2012-06-26 [PMID: 22743091] (IF/IHC, Mouse)	IF/IHC	Mouse
Diaz-Castro B, Pintado CO, Garcia-Flores P et al. Differential impairment of catecholaminergic cell maturation and survival by genetic mitochondrial complex II dysfunction Mol Cell Biol 2012-08-01 [PMID: 22711987] (IF/IHC, Mouse)	IF/IHC	Mouse
Daher JP, Pletnikova O, Biskup S et al. Neurodegenerative phenotypes in an A53T alpha-synuclein transgenic mouse model are independent of LRRK2 Hum Mol Genet 2012-03-07 [PMID: 22357653] (IF/IHC, Mouse)	IF/IHC	Mouse
Hidalgo-Figueroa M, Bonilla S, Gutierrez F et al. GDNF Is Predominantly Expressed in the PV+ Neostriatal Interneuronal Ensemble in Normal Mouse and after Injury of the Nigrostriatal Pathway. J Neurosci 1832(3):864-872. 2012-01-01 [PMID: 22262884] (IF/IHC, Mouse)	IF/IHC	Mouse
Neddens J, Buonanno A. Expression of the neuregulin receptor ErbB4 in the brain of the rhesus monkey (Macaca mulatta). PLoS One 2011-01-01 [PMID: 22087295]
Benmoyal-Segal L, Soreq L, Ben-Shaul Y et al. Adaptive alternative splicing correlates with less environmental risk of parkinsonism Neurodegener Dis 2012-01-01 [PMID: 22042332]
Herzig MC, Kolly C, Persohn E et al. LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice. Hum Mol Genet. 2011-11-01 [PMID: 21828077] (IHC-P, Mouse)	IHC-P	Mouse
Ramonet D, Daher J, Lin B et al. Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2 PLoS One 2011-04-06 [PMID: 21494637] (ICC/IF, IF/IHC, Mouse)	ICC/IF, IF/IHC	Mouse
Lee S, Craddock Z, Rivier C. Brain stem catecholamines circuitry: activation by alcohol and role in the hypothalamic-pituitary-adrenal response to this drug. J Neuroendocrinol;23(6):531-41. 2011-06-01 [PMID: 21447066] (IF/IHC, Rat)	IF/IHC	Rat
Shin J-H, Ko HS, Kang H et al. PARIS (ZNF746) repression of PGC-1[alpha] contributes to neurodegeneration in Parkinson’s disease. Cell;144(5):689-702. 2011-03-04 [PMID: 21376232] (ICC/IF, Mouse)	ICC/IF	Mouse
Ng BW Levodopa-Mediated Changes in Cerebellar Neuronal Activity in Parkinson's Disease Thesis 1905-07-13 (IF/IHC, Rat)	IF/IHC	Rat
Kunz TH, Scott M, Ittner LM et al. Calcitonin gene-related peptide-evoked sustained tachycardia in calcitonin receptor-like receptor transgenic mice is mediated by sympathetic activity. Am J Physiol Heart Circ Physiol 2007-10-01 [PMID: 17660394] (IF/IHC, Mouse)	IF/IHC	Mouse
Ben-Shaul Y, Benmoyal-Segal L, Ben-Ari S et al. Adaptive acetylcholinesterase splicing patterns attenuate 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinsonism in mice. Eur J Neurosci 2006-06-01 [PMID: 16819980]
Tal Y, Anavi S, Reisman M et al. The neuroprotective properties of a novel variety of passion fruit. Journal of Functional Foods. 2016-03-31 (IF/IHC)	IF/IHC
Zhang J, Tang T, Zhang R et al. Maintaining Toll Signaling in Drosophila Brain is Required to Sustain Autophagy for Dopamine Neuron Survival papers.ssrn.com 2023-03-09 (IHC)	IHC
Mao R, Yu J, Deng B et al. Conditional Chemoconnectomics: A Set of Libraries Targeting All Chemical Transmission Corresponding Genes Efficiently bioRxiv 2023-09-28 (IHC, Insect) Details: Dilution 1:1000	IHC	Insect
Alekseyenko OV, Lee C, Kravitz EA. Targeted manipulation of serotonergic neurotransmission affects the escalation of aggression in adult male Drosophila melanogaster. PLoS One;5(5):e10806. 2010-05-24 [PMID: 20520823] (IF/IHC, Drosophila)	IF/IHC	Drosophila
Andres-Mateos E, Mejias R, Sasaki M et al. Unexpected lack of hypersensitivity in LRRK2 knock-out mice to MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine). J Neurosci;29(50):15846-50. 2009-12-16 [PMID: 20016100] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Venderova K, Kabbach G, Abdel-Messih E et al. Leucine-Rich Repeat Kinase 2 interacts with Parkin, DJ-1 and PINK-1 in a Drosophila melanogaster model of Parkinson's disease. Hum Mol Genet;18(22):4390-404. 2009-11-15 [PMID: 19692353] (ICC/IF, Drosophila)	ICC/IF	Drosophila
Li XZ, Bai LM, Yang YP et al. Effects of IL-6 secreted from astrocytes on the survival of dopaminergic neurons in lipopolysaccharide-induced inflammation. Neurosci Res 2009-11-01 [PMID: 19647022] (ICC/IF, Rat)	ICC/IF	Rat
Andres-Mateos E, Perier C, Zhang L et al. DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase. Proc Natl Acad Sci U S A 104(37):14807-12. 2007-09-11 [PMID: 17766438] (IF/IHC, Mouse)	IF/IHC	Mouse
von Coelln, R et al. Loss of locus coeruleus neurons reduced startle in parkin null mice. PNAS 101: 10744-10749. 2004-01-01 [PMID: 15249681] (WB, IF/IHC, Mouse)	WB, IF/IHC	Mouse
Selvage, D et al. A Hypothalamic-Testicular Neural Pathway Is Influenced by Brain Catecholamines, But Not Testicular Blood Flow. Endocrinology 145(4): 1750-1759. [PMID: 14684600] (ICC/IF, Rat)	ICC/IF	Rat
May CE, Rosander J, Gottfried J, et al. Dietary sugar inhibits satiation by decreasing the central processing of sweet taste bioRxiv (IHC, Drosophila)	IHC	Drosophila
Guo, Z et al. Central pathways in the pons midbrain involved in cardiac sympathoexcitatory reflexes in cats. Neuroscience; 113(2):435-447. 2002-01-01 [PMID: 12127100]
Nocjar, C et al. Localization of 5-HT2A receptors on dopamine cells in subnuclei of the midbrain A10 cell group. Neuroscience; 113(1): 163-176. 2002-01-01 [PMID: 11955720]
Guo ZL, Lai HC, Longhurst JC. Medullary pathways involved in cardiac sympathoexcitatory reflexes in the cat. Brain Res;925(1):55-66. 2002-01-18 [PMID: 11755900]
Yan J, Huang J, Wu J et al. Atorvastatin Alleviates Behavioral Symptoms in MPTP-lesioned Mice: Associated With NOX2-mediated Autophagy and Oxidative Stress Research Square 2020-09-17 (IF/IHC, Mouse)	IF/IHC	Mouse
Tucker HR Deep Brain Stimulation of the Ventral Anterior and Ventrolateral Nuclei of the Thalamus as an Effective Neuromodulatory Approach to Treat Parkinsons Disease Symptoms Thesis 2020-01-01
Quick KL, Dugan LL. Superoxide stress identifies neurons at risk in a model of ataxia-telangiectasia. Ann Neurol. 2001-05-01 [PMID: 11357953] (Mouse)		Mouse
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Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: michele d'angelo	IHC-Fr	Mouse	02/12/2020	View Summary Application Immunohistochemistry-Frozen Sample Tested brian tissue Species Mouse Lot ajo1215y
Enlarge	5 reviewed by: Bianca Kerschbaumer	ICC	Mouse	05/19/2017	View Summary Application Immunocytochemistry Sample Tested Brain (substantia nigra),mouse eye Species Mouse Lot ajo616p Comments Comments cryo sections mouse: primary antibody: anti-rb TH: 1:500; o.n. secondary antibody: 1:500 dk-anti-rb DyLight488 (Agrisera, AS10 1165)
	4 reviewed by: Yoshitaka Hamanaka	ICC	Cockroach and Cricket	02/15/2017	View Summary Application Immunocytochemistry Sample Tested Brain Species Cockroach and Cricket
Enlarge	5 reviewed by: Verified Customer	ICC	Rat	03/27/2015	View Summary Application Immunocytochemistry Sample Tested Mesenteric artery-whole Species Rat Lot AJ0314b
Enlarge	5 reviewed by: Verified Customer	IF	Mouse	02/24/2014	View Summary Application Immunofluorescence Sample Tested mouse brain Species Mouse
Enlarge	5 reviewed by: Naoharu Takano	WB	Rat	01/03/2012	View Summary Application Western Blot Sample Tested PC12 cell whole lysate, Sample Amount: 12ug Species Rat
	5 reviewed by: Verified Customer	IF	Other	02/04/2010	View Summary Application Immunofluorescence Sample Tested mouse brain Species Other Lot ajo209

Array NB300-109

• Tyrosine Hydroxylase Antibodies
• Tyrosine Hydroxylase ELISA Kits
• Tyrosine Hydroxylase Lysate
• Tyrosine Hydroxylase Proteins