CD14 Antibody

CD14 is a single copy gene encoding 2 protein forms a 50 to 55 kDa glycosylphosphatidylinositol anchored membrane protein (mCD14) and a monocyte or liver derived soluble serum protein (sCD14) that lacks the anchor. Both molecules are critical for lipopolysaccharide (LPS) dependent signal transduction, and sCD14 confers LPS sensitivity to cells lacking mCD14. Increased sCD14 levels are associated with inflammatory infectious diseases and high mortality in gram negative shock. CD14 also appears to be involved in clearance of gram-negative bacteria via its high affinity binding to LPS-LPB complexes.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: ICC/IF, WB.

Showing Publications 1 - 3 of 3.

Publications using NB100-2807	Applications	Species
Martin I, Caban-Hernandez K, Figueroa-Santiago O, Espino AM. Fasciola hepatica Fatty Acid Binding Protein Inhibits TLR4 Activation and Suppresses the Inflammatory Cytokines Induced by Lipopolysaccharide In Vitro and In Vivo J. Immunol. 2015-03-16 [PMID: 25780044] (ICC/IF, WB, Human)	ICC/IF, WB	Human
Iwaki D, Nishitani C, Mitsuzawa H et al. The CD14 region spanning amino acids 57-64 is critical for interaction with the extracellular Toll-like receptor 2 domain. Biochem Biophys Res Commun 2005-03-04 [PMID: 15670766]
Funda DP, Tuckova L, Farre MA et al. CD14 is expressed and released as soluble CD14 by human intestinal epithelial cells in vitro: lipopolysaccharide activation of epithelial cells revisited. Infect Immun 2001-06-01 [PMID: 11349042]

Array NB100-2807

• CD14 Antibodies
• CD14 Antibody Pair
• CD14 Lysates
• CD14 Proteins
• CD14 ELISAs
• CD14 Proteins and Enzymes