CD14 Products

Description

CD14 is a 53-55 kD glycosylphosphatidylinositol (GPI)-linked membrane glycoprotein also known as LPS receptor. CD14 is expressed at high levels on monocytes and macrophages, and at lower levels on granulocytes. Some dendritic cell populations such as interfollicular dendritic cells, reticular dendritic cells, and Langerhans cells have also been reported to express CD14. As a high-affinity receptor for LPS, CD14 is involved in the clearance of gram-negative pathogens and in the upregulation of adhesion molecules and cytokines expression in monocytes and neutrophils. The M5E2 antibody inhibits monocyte activation and cytokine production induced by LPS.

Bioinformatics

Entrez	12475 Mouse 929 Human
Uniprot	AAH10507 Human AAH10507.1 Human NM_000591 Human NM_001040021 Human NP_000582 Human NP_000582.1 Human P08571 Human P10810 Mouse
Product By Gene ID	929
Alternate Names	CD14 antigen CD14 molecule monocyte differentiation antigen CD14 Myeloid cell-specific leucine-rich glycoprotein

Research Areas for CD14

Find related products by research area and learn more about each of the different research areas below.

Adaptive Immunity
Apoptosis
Asthma
Biologically Active Proteins
Cancer
CD Markers
Cell Biology
Cytokine Research
Immunology
Innate Immunity
Myeloid Cell Markers
Stem Cell Markers

Related CD14 Blog Posts

Check out the latest blog posts on CD14.

The role of TLR4 in breast cancer Toll like receptors (TLRs) are highly conserved proteins that are first known for their role in pathogen recognition and immune response activation.  In order to elicit the necessary immune response in reaction to a foreign pathogen, TLRs trigger cy...    Read more.

CD11b: Marker for a New Type of B Cell that Participates in Cell-Mediated Immunity Think B lymphocytes just produce antibodies? Think again! Although, of course, B cells are vital for the humoral immune response, many studies in recent years have begun to uncover antibody-independent actions of B cells: regulating T cells and thus a...    Read more.

CD14 - TLR4 is my friend in battle against infections! CD14 is a well-characterized cell-activating receptor for lipopolysaccharide-binding protein (LBP) and peptidoglycan. It is an important modulator for lipopolysaccharide (LPS)-dependent signaling and is a component of the multi-protein complex contain...    Read more.

Read more CD14 related blogs.