MAP2 Antibody

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Microtubule-associated protein 2 also known as MAP2 (theoretical molecular weight 280 kDa) belongs to the MAP2/Tau family which in addition to the two neuronal forms MAP2 and Tau also includes MAP4 (1). For MAP2, four different isoforms have been identified which are produced through alternative splicing including MAP2a, MAP2b, MAP2c and MAP2d (1). MAP2 isoforms contain multiple microtubule-binding domains located near the carboxy terminal, a variably sized amino-terminal projection domain, and a conserved protein kinase A binding domain. MAP2c and MAP2d isoforms have a shorter amino-terminal projection domain, lower molecular weight and are identifiable at ~70 kDa in SDS-PAGE analysis (2,3). MAP2's carboxy terminal domain supports interactions with microtubules, actin, and intermediate filaments (2).

MAP2 isoforms are developmentally regulated and differentially expressed in neurons and some glia. MAP2c is predominantly expressed in the developing brain while the other isoforms are expressed in the adult brain. The distribution of MAP2 isoforms also varies, with MAP2a and MAP2b predominantly localized to dendrites, while MAP2c is also found in axons. Lastly, the expression of MAP2d is not limited to neurons and may be found in glia, specifically oligodendrocytes (1, 2). MAP2 isoforms associate with microtubules and mediate their interaction with actin filaments thereby playing a critical role in organizing the microtubule-actin network. In neurons, MAP2 isoforms are implicated in different processes including neurite initiation, elongation and stabilization as well as axon and dendrite formation (2). Knockout of MAP expression in animal models results in a variety of functional and structural brain defects according to the isoform affected (e.g., reduced LTP and LTD, reduced myelination, absence of corpus collosum, motor system malfunction, abnormal hippocampal dendritic morphology, abnormal synaptic plasticity) (4).

References

1. Dehmelt, L., & Halpain, S. (2005). The MAP2/Tau family of microtubule-associated proteins. Genome Biology. https://doi.org/10.1186/gb-2004-6-1-204

2. Mohan, R., & John, A. (2015). Microtubule-associated proteins as direct crosslinkers of actin filaments and microtubules. IUBMB Life. https://doi.org/10.1002/iub.1384

3. Shafit-Zagardo, B., & Kalcheva, N. (1998). Making sense of the multiple MAP-2 transcripts and their role in the neuron. Molecular Neurobiology. https://doi.org/10.1007/BF02740642

4. Tortosa, E., Kapitein, L. C., & Hoogenraad, C. C. (2016). Microtubule organization and microtubule-associated proteins (MAPs). In Dendrites: Development and Disease. https://doi.org/10.1007/978-4-431-56050-0_3

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 8 applications: ICC/IF, IF, IF/IHC, IHC, IHC-Fr, KD, PLA, WB.

Showing Publications 1 - 10 of 109. Show All 109 Publications. Collapse Publications.

Publications using NB300-213	Applications	Species
Daniel JA, Elizarova S, Shaib AH et al. An intellectual-disability-associated mutation of the transcriptional regulator NACC1 impairs glutamatergic neurotransmission Frontiers in Molecular Neuroscience 2023-07-14 [PMID: 37533751]
Sinha Ray S, Dutta D, Dennys C et al. Mechanisms of IRF2BPL-related disorders and identification of a potential therapeutic strategy Cell reports 2022-12-06 [PMID: 36476864] (ICC/IF, Human)	ICC/IF	Human
Thibaudeau A, Schmitt K, François L et al. Pharmacological modulation of developmental and synaptic phenotypes in human SHANK3 deficient stem cell-derived neuronal models bioRxiv 2023-09-13 (ICC/IF, Human)	ICC/IF	Human
Escarcega RD, Patil AA, Moruno-Manchon JF et al. Pirh2-dependent DNA damage in neurons induced by the G-quadruplex ligand pyridostatin Journal of Biological Chemistry 2023-08-12 [PMID: 37579947]
Loedige I, Baranovskii A, Mendonsa S et al. mRNA stability and m6A are major determinants of subcellular mRNA localization in neurons Molecular cell 2023-07-12 [PMID: 37451262] (ICC/IF, Mouse)	ICC/IF	Mouse
Bonazzi S, Gray A, Thomsen NM et al. Identification of Brain-Penetrant ATP-Competitive mTOR Inhibitors for CNS Syndromes Journal of medicinal chemistry 2023-07-13 [PMID: 37399505]
Kambali M, Li Y, Unichenko P et al. A marker chromosome in psychosis identifies glycine decarboxylase (GLDC) as a novel regulator of neuronal and synaptic function in the hippocampus bioRxiv : the preprint server for biology 2023-05-29 [PMID: 37398055]
Sierra-Delgado JA, Sinha-Ray S, Kaleem A et al. In Vitro Modeling as a Tool for Testing Therapeutics for Spinal Muscular Atrophy and IGHMBP2-Related Disorders Biology 2023-06-16 [PMID: 37372153] (ICC/IF, Human)	ICC/IF	Human
Nelson AT, Cicardi ME, Markandaiah SS et al. Glucose Hypometabolism Prompts RAN Translation and Exacerbates C9orf72-related ALS/FTD Phenotypes bioRxiv : the preprint server for biology 2023-06-07 [PMID: 37333144] (ICC/IF, Human) Details: 1:500 dilution	ICC/IF	Human
Isosaari L, Vuorenpää H, Yrjänäinen A et al. Simultaneous induction of vasculature and neuronal network formation on a chip reveals a dynamic interrelationship between cell types Cell communication and signaling : CCS 2023-06-14 [PMID: 37316873] (ICC/IF, Human) Details: 1:200 dilution	ICC/IF	Human
Ichinose S, Susuki Y, Hosoi N et al. Interaction between Teneurin-2 and microtubules via EB proteins provides a platform for GABAA receptor exocytosis eLife 2023-06-05 [PMID: 37272607] (PLA, ICC/IF)	PLA, ICC/IF
Yang G, Ullah HMA, Parker E et al. Neurite outgrowth deficits caused by rare PLXNB1 mutation in pediatric bipolar disorder Molecular psychiatry 2023-04-10 [PMID: 37032361]
Choong CJ, Aguirre C, Kakuda K et al. Phosphatidylinositol-3,4,5-trisphosphate interacts with alpha-synuclein and initiates its aggregation and formation of Parkinson's disease-related fibril polymorphism Acta neuropathologica 2023-03-20 [PMID: 36939875] (ICC/IF, IHC-Fr, Mouse, Human) Details: Dilution used in IHC-Fr and ICC/IF 1:5000	ICC/IF, IHC-Fr	Mouse, Human
Kapucu F, Tujula I, Kulta O et al. Human tripartite cortical network model for temporal assessment of alpha-synuclein aggregation and propagation in Parkinson’s Disease Research Square 2023-10-05 (ICC/IF, Human)	ICC/IF	Human
Bocharova O, Makarava N, Pandit N et al. Multiple steps of prion strain adaptation to a new host bioRxiv 2023-10-27 [PMID: 37961127] (WB, Mouse)	WB	Mouse
Shiers S, Funk G, Cervantes A et al. Na(V)1.7 mRNA and protein expression in putative projection neurons of the human spinal dorsal horn bioRxiv 2023-02-09 [PMID: 36778234] (IHC)	IHC
Borisova E Studies on the formation of cortical circuits Thesis 2022-01-01 (ICC/IF, Mouse)	ICC/IF	Mouse
Singh B Investigating the mechanisms underlying synaptic and cognitive deficits in alpha-synucleinopathies Thesis 2019-01-01 (ICC/IF, Mouse)	ICC/IF	Mouse
Buscaglia GC Tuba1a microtubules establish the foundations for neuronal function Thesis 2020-01-01
Cicardi ME, Hallgren JH, Mawrie D et al. C9orf72 poly(PR) mediated neurodegeneration is associated with nucleolar stress iScience 2023-09-15 [PMID: 37664610]
Falkovich R, Danielson EW, Perez de Arce K et al. A synaptic molecular dependency network in knockdown of autism- and schizophrenia-associated genes revealed by multiplexed imaging Cell reports 2023-04-25 [PMID: 37099425] (ICC/IF, Rat)	ICC/IF	Rat
Malik AM, Wu JJ, Gillies CA et al. Neuronal activity regulates Matrin 3 abundance and function in a calcium-dependent manner through calpain-mediated cleavage and calmodulin binding Proceedings of the National Academy of Sciences of the United States of America 2023-04-11 [PMID: 37011198] (ICC/IF, Rat)	ICC/IF	Rat
Juntunen M Development of Adipose-Derived Stromal/stem Cell-Based Therapies : Effects of donor weight and culture conditions on cell characteristics and testing the efficacy in stroke models Thesis 2022-01-01 (ICC/IF, Human)	ICC/IF	Human
Cicardi ME, Hallgren JH, Mawrie D et al. C9orf72 poly(PR) mediated neurodegeneration is associated with nucleolar stress bioRxiv 2023-02-16 [PMID: 36824930] (ICC/IF)	ICC/IF
Ren Y, Huang Z, Zhou L et al. Spatial transcriptomics reveals niche-specific enrichment and vulnerabilities of radial glial stem-like cells in malignant gliomas Nature communications 2023-02-23 [PMID: 36823172] (ICC/IF, Human)	ICC/IF	Human
Griffin H, Sullivan S, Barger S et al. Liraglutide Counteracts Endoplasmic Reticulum Stress in Palmitate-Treated Hypothalamic Neurons without Restoring Mitochondrial Homeostasis International Journal of Molecular Sciences 2022-12-30 [PMID: 36614074] (ICC/IF, Mouse)	ICC/IF	Mouse
RAsAnen N, Harju V, Joki T, Narkilahti S Practical guide for preparation, computational reconstruction and analysis of 3D human neuronal networks in control and ischaemic conditions Development (Cambridge, England) 2022-10-15 [PMID: 35929583] (ICC/IF, Human) Details: Neurons in hydrogels, dilution used 1:2000	ICC/IF	Human
Bauer CS, Cohen RN, Sironi F et al. An interaction between synapsin and C9orf72 regulates excitatory synapses and is impaired in ALS/FTD Acta Neuropathologica 2022-09-01 [PMID: 35876881] (IHC)	IHC
Bulumulla C, Krasley AT, Cristofori-Armstrong B et al. Visualizing synaptic dopamine efflux with a 2D composite nanofilm eLife 2022-07-04 [PMID: 35786443] (ICC/IF, Rat)	ICC/IF	Rat
Li P, Liu B, Wu X et al. Perirenal adipose afferent nerves sustain pathological high blood pressure in rats Nature Communications 2022-06-06 [PMID: 35668093] (ICC/IF)	ICC/IF
Shi HJ, Wu DL, Chen R et al. Requirement of hippocampal DG nNOS-CAPON dissociation for the anxiolytic and antidepressant effects of fluoxetine Theranostics 2022-05-01 [PMID: 35664081] (ICC/IF, Mouse)	ICC/IF	Mouse
Zhao Y, Hu D, Wang R et al. ATAD3A oligomerization promotes neuropathology and cognitive deficits in Alzheimer's disease models Nature communications 2022-03-02 [PMID: 35236834] (ICC/IF, Mouse)	ICC/IF	Mouse
Harbauer AB, Hees JT, Wanderoy S et al. Neuronal mitochondria transport Pink1 mRNA via synaptojanin 2 to support local mitophagy Neuron 2022-02-19 [PMID: 35216662]
Buscaglia G, Northington KR, Aiken J et al. Bridging the Gap: The Importance of TUBA1A ?-Tubulin in Forming Midline Commissures Frontiers in Cell and Developmental Biology 2022-01-19 [PMID: 35127710]
Mzezewa R, Lotila J, Kiiski H et al. A kainic acid-induced seizure model in human pluripotent stem cell-derived cortical neurons for studying the role of IL-6 in the functional activity Stem cell research 2022-01-17 [PMID: 35091307] (ICC/IF, Human)	ICC/IF	Human
Dickerson MR, Murphy SF, Urban MJ et al. Chronic Anxiety- and Depression-Like Behaviors Are Associated With Glial-Driven Pathology Following Repeated Blast Induced Neurotrauma Frontiers in behavioral neuroscience 2021-12-10 [PMID: 34955781] (IF/IHC, Rat)	IF/IHC	Rat
Samanta S, YlA-Outinen L, Rangasami VK et al. Bidirectional cell-matrix interaction dictates neuronal network formation in a brain-mimetic 3D scaffold Acta biomaterialia 2021-12-10 [PMID: 34902615] (ICC/IF, Human)	ICC/IF	Human
Tian Y, Wang Y, Jablonski AM Et al. Tau-tubulin kinase 1 phosphorylates TDP-43 at disease-relevant sites and exacerbates TDP-43 pathology Neurobiology of disease 2021-11-06 [PMID: 34752923] (ICC/IF, Human)	ICC/IF	Human
Lipstein N, Chang S, Lin KH Et al. Munc13-1 is a Ca2+-phospholipid-dependent vesicle priming hub that shapes synaptic short-term plasticity and enables sustained neurotransmission Neuron 2021-10-21 [PMID: 34706220] (ICC/IF, Mouse)	ICC/IF	Mouse
Pollard KJ, Bowser DA, Anderson WA Et al. Morphine-sensitive synaptic transmission emerges in embryonic rat microphysiological model of lower afferent nociceptive signaling Science advances 2021-08-01 [PMID: 34452921] (IF/IHC, Rat)	IF/IHC	Rat
Kang Y, Zhou Y, Li Y Et al. A human forebrain organoid model of fragile X syndrome exhibits altered neurogenesis and highlights new treatment strategies Nature neuroscience 2021-08-19 [PMID: 34413513] (ICC/IF, Human)	ICC/IF	Human
Blumenstock S, Schulz-Trieglaff EK, Voelkl K et al. Fluc-EGFP reporter mice reveal differential alterations of neuronal proteostasis in aging and disease The EMBO Journal 2021-10-01 [PMID: 34410010] (WB)	WB
Yuste-Checa P, Trinkaus VA, Riera-Tur I et al. The extracellular chaperone Clusterin enhances Tau aggregate seeding in a cellular model Nature Communications 2021-08-11 [PMID: 34381050]
Basu H, Pekkurnaz G, Falk J Et al. FHL2 anchors mitochondria to actin and adapts mitochondrial dynamics to glucose supply The Journal of cell biology 2021-10-04 [PMID: 34342639] (ICC/IF)	ICC/IF
Trinkaus VA, Riera-Tur I, MartInez-SAnchez A et al. In situ architecture of neuronal alpha-Synuclein inclusions Nature communications 2021-04-14 [PMID: 33854052]
Srikanth MP, Jones JW, Kane M et al. Elevated glucosylsphingosine in Gaucher disease induced pluripotent stem cell neurons deregulates lysosomal compartment through mammalian target of rapamycin complex 1 Stem cells translational medicine 2021-03-03 [PMID: 33656802] (ICC/IF, Human)	ICC/IF	Human
Jablonski AM, Warren L, Usenovic M et al. Astrocytic expression of the Alzheimer's disease risk allele, ApoE epsilon 4, potentiates neuronal tau pathology in multiple preclinical models Scientific reports 2021-02-09 [PMID: 33564035] (ICC/IF, Rat)	ICC/IF	Rat
Chiola S, Napan KL, Wang Y et al. Defective AMPA-mediated synaptic transmission and morphology in human neurons with hemizygous SHANK3 deletion engrafted in mouse prefrontal cortex Molecular psychiatry 2021-02-08 [PMID: 33558651] (IF/IHC, Mouse)	IF/IHC	Mouse
Tribble JR, Otmani A, Kokkali E et al. Retinal Ganglion Cell Degeneration in a Rat Magnetic Bead Model of Ocular Hypertensive Glaucoma Translational Vision Science & Technology 2021-01-12 [PMID: 33510960] (ICC/IF)	ICC/IF
Danielson E, Perez de Arce K, Cimini B et al. Molecular Diversity of Glutamatergic and GABAergic Synapses from Multiplexed Fluorescence Imaging eNeuro 2020-12-16 [PMID: 33355295] (ICC/IF)	ICC/IF
Yu H, Lu S, Gasior K et al. TDP-43 and HSP70 phase separate into anisotropic, intranuclear liquid spherical annuli bioRxiv 2020-01-01 [PMID: 33335017]
Juntunen M, Hagman S, Moisan A et al. In Vitro Oxygen-Glucose Deprivation-Induced Stroke Models with Human Neuroblastoma Cell- and Induced Pluripotent Stem Cell-Derived Neurons Stem Cells International 2020-10-29 [PMID: 33178286] (ICC/IF, Human)	ICC/IF	Human
Lee YL, Kung FC, Lin CH, Huang YS CMTR1-Catalyzed 2'-O-Ribose Methylation Controls Neuronal Development by Regulating Camk2 alpha Expression Independent of RIG-I Signaling Cell Rep 2020-10-20 [PMID: 33086056] (Mouse)		Mouse
Pelkonen A, Mzezewa R, Sukki L et al. A modular brain-on-a-chip for modelling epileptic seizures with functionally connected human neuronal networks Biosens Bioelectron 2020-01-01 [PMID: 32877779] (ICC/IF)	ICC/IF
Sun H, Zhang H, Ross A et al. Developmentally Regulated Rebound Depolarization Enhances Spike Timing Precision in Auditory Midbrain Neurons Front Cell Neurosci 2020-08-06 [PMID: 32848625] (IF/IHC, Rat)	IF/IHC	Rat
Teodorof-Diedrich C, Spector SA Human Immunodeficiency Virus Type-1 and Methamphetamine Mediated Mitochondrial Damage and Neuronal Degeneration in Human Neurons J. Virol. 2020-08-12 [PMID: 32796068]
Inglis G, Zhou Y, Patterson D et al. Transcriptomic and epigenomic dynamics associated with development of human iPSC-derived GABAergic interneurons Human Molecular Genetics 2020-07-16 [PMID: 32794569] (ICC/IF, WB, Human)	ICC/IF, WB	Human
Szczurkowska J, Lee SI, Guo A et al. A Localized Scaffold for cGMP Increase Is Required for Apical Dendrite Development Cell Rep 2020-04-14 [PMID: 32294442] (ICC/IF, KD, Human)	ICC/IF, KD	Human
Ripamonti S, Shomroni O, Rhee JS et al. SUMOylation controls the neurodevelopmental function of the transcription factor Zbtb20 J. Neurochem. 2020-03-31 [PMID: 32233089] (ICC/IF, Human)	ICC/IF	Human
Maus L, Lee C, Altas B et Al. Ultrastructural Correlates of Presynaptic Functional Heterogeneity in Hippocampal Synapses Cell Rep 2020-03-17 [PMID: 32187536] (IF/IHC, Mouse)	IF/IHC	Mouse
Kim BW, Jeong YE, Wong M, Martin LJ DNA damage accumulates and responses are engaged in human ALS brain and spinal motor neurons and DNA repair is activatable in iPSC-derived motor neurons with SOD1 mutations Acta Neuropathol Commun 2020-01-31 [PMID: 32005289] (WB, Human)	WB	Human
Toh MF, Brooks JM, Strassmaier T et al. Application of High-Throughput Automated Patch-Clamp Electrophysiology to Study Voltage-Gated Ion Channel Function in Primary Cortical Cultures SLAS Discov 2020-01-31 [PMID: 32003306] (WB)	WB
Bonazzi S, Goold CP, Gray A et al. Discovery of a Brain-Penetrant ATP-Competitive Inhibitor of the Mechanistic Target of Rapamycin (mTOR) for CNS Disorders J. Med. Chem. 2020-02-13 [PMID: 31955578]
HyvArinen T, Hyysalo A, Kapucu FE et al. Functional characterization of human pluripotent stem cell-derived cortical networks differentiated on laminin-521 substrate: comparison to rat cortical cultures Sci Rep 2019-11-20 [PMID: 31748598] (ICC/IF, Rat)	ICC/IF	Rat
Sen T, Saha P, Gupta R, et al. Aberrant ER-stress induced neuronal-IFN beta elicits white matter injury due to microglial activation and T-cell infiltration after TBI. J Neurosci. [PMID: 31694961] (IF, Mouse)	IF	Mouse
Subramanian J, Michel K, Benoit M, Nedivi E CPG15/Neuritin Mimics Experience in Selecting Excitatory Synapses for Stabilization by Facilitating PSD95 Recruitment Cell Rep 2019-08-06 [PMID: 31390571] (ICC/IF, Mouse, Human)	ICC/IF	Mouse, Human
Cuesta Torres LF, Zhu W, Ohrling G et al. An Autaptic Culture System for Standardized Analyses of iPSC-Derived Human Neurons Cell Rep 2019-05-14 [PMID: 31091457] (ICC/IF, Mouse, Rat)	ICC/IF	Mouse, Rat
Gasset-Rosa F, Lu S, Yu H et al. Cytoplasmic TDP-43 De-mixing Independent of Stress Granules Drives Inhibition of Nuclear Import, Loss of Nuclear TDP-43, and Cell Death Neuron 2019-03-05 [PMID: 30853299] (ICC/IF, Human)	ICC/IF	Human
Kobayakawa K, DePetro KA, Zhong H et al. Locomotor Training Increases Synaptic Structure With High NGL-2 Expression After Spinal Cord Hemisection Neurorehabil Neural Repair 2019-02-19 [PMID: 30782076] (IHC-Fr, Rat)	IHC-Fr	Rat
Bathini P, Mottas A, Jaquet M et al. Progressive signaling changes in the olfactory nerve of patients with Alzheimer's disease Neurobiol. Aging 2019-04-01 [PMID: 30708185] (ICC/IF, Human)	ICC/IF	Human
Aiken J, Moore J, Bates E. TUBA1A mutations identified in lissencephaly patients dominantly disrupt neuronal migration and impair dynein activity. bioRxiv 2018-07-25 [PMID: 30517687] (ICC/IF, Rat)	ICC/IF	Rat
Ambrozkiewicz MC, Schwark M, Kishimoto-Suga M et al. Polarity Acquisition in Cortical Neurons Is Driven by Synergistic Action of Sox9-Regulated Wwp1 and Wwp2 E3 Ubiquitin Ligases and Intronic miR-140. Neuron. 2018-10-30 [PMID: 30392800] (ICC/IF, Mouse)	ICC/IF	Mouse
Lopez-Erauskin J, Tadokoro T, Baughn MW et al. ALS/FTD-Linked Mutation in FUS Suppresses Intra-axonal Protein Synthesis and Drives Disease Without Nuclear Loss-of-Function of FUS. Neuron. 2018-10-17 [PMID: 30344044] (Mouse)		Mouse
khan SS, LaCroix M, BoYle G et al. Bidirectional modulation of Alzheimer phenotype by alpha-synuclein in mice and primary neurons. Acta Neuropathol. 2018-07-11 [PMID: 29995210] (ICC/IF, Mouse)	ICC/IF	Mouse
Zhu LJ, Ni HY, Chen R et al. Hippocampal NF-kB accounts for stress-induced anxiety behaviors via enhancing nNOS-CAPON-Dexras1 coupling J. Neurochem. 2018-06-02 [PMID: 29858554] (Mouse)		Mouse
Stankova T, Piepkorn L, Bayer TA et al. SUMO1-conjugation is altered during normal aging but not by increased amyloid burden. Aging Cell 2018-04-06 [PMID: 29633471] (IF/IHC, Mouse)	IF/IHC	Mouse
Hsu F, Spannl S, Ferguson C et al. Rab5 and Alsin regulate stress-activated cytoprotective signaling on mitochondria. bioRxiv. [PMID: 29469808] (ICC/IF, Human)	ICC/IF	Human
Paavilainen T, Pelkonen A, Makinen ME, Peltola M. Effect of prolonged differentiation on functional maturation of human pluripotent stem cell-derived neuronal cultures. Stem Cell Res. 2018-01-29 [PMID: 29414606] (Human)		Human
Daniel JA, Cooper BH, Palvimo JJ et al. Analysis of SUMO1-conjugation at synapses Elife 2017-06-09 [PMID: 28598330] (ICC/IF, Mouse)	ICC/IF	Mouse
Amar F, Sherman MA, Rush T et al. The amyloid-B oligomer AB*56 induces specific alterations in neuronal signaling that lead to tau phosphorylation and aggregation. Sci Signal. 2017-05-09 [PMID: 28487416] (Human)		Human
Zhao J, Davis MD, Martens YA et al. APOE E4/E4 diminishes neurotrophic function of human iPSC-derived astrocytes. Hum. Mol. Genet. 2017-07-15 [PMID: 28444230] (ICC/IF, Human)	ICC/IF	Human
Ripamonti S, Ambrozkiewicz MC, Guzzi F et al. Transient oxytocin signaling primes the development and function of excitatory hippocampal neurons. Elife. 2017-02-23 [PMID: 28231043] (ICC/IF, Mouse)	ICC/IF	Mouse
Lagerlof O, Hart GW, Huganir RL. O-GlcNAc transferase regulates excitatory synapse maturity Proc. Natl. Acad. Sci. U.S.A 2017-01-31 [PMID: 28143929] (IF/IHC, Mouse)	IF/IHC	Mouse
Sherman M A, LaCroix M et al. Soluble Conformers of A beta and Tau Alter Selective Proteins Governing Axonal Transport. J Neurosci 2016-09-14 [PMID: 27629715] (WB, Mouse)	WB	Mouse
Ciaraldi TP, Ryan AJ, Mudaliar SR, Henry RR Altered Myokine Secretion Is an Intrinsic Property of Skeletal Muscle in Type 2 Diabetes. PLoS One 2016-07-25 [PMID: 27453994] (ICC/IF, Human)	ICC/IF	Human
Verma N, Ly H, Liu M et al. Intraneuronal Amylin Deposition Peroxidative Membrane Injury and Increased IL-1beta Synthesis in Brains of Alzheimer's Disease Patients with Type-2 Diabetes and in Diabetic HIP Rats. J. Alzheimers Dis. 2016-05-05 [PMID: 27163815] (ICC/IF, Rat)	ICC/IF	Rat
Haas LT, Salazar SV, Kostylev MA et al. Metabotropic glutamate receptor 5 couples cellular prion protein to intracellular signalling in Alzheimer's disease. Brain. 2015-12-14 [PMID: 26667279] (ICC/IF, Mouse)	ICC/IF	Mouse
Zhou H, Liu G. Regulation of density of functional presynaptic terminals by local energy supply. Mol Brain 2015-01-01 [PMID: 26184109] (ICC/IF)	ICC/IF
Usui Y, Westenskow PD, Kurihara T et al. Neurovascular crosstalk between interneurons and capillaries is required for vision. J. Clin. Invest. 2015-06-01 [PMID: 25915585] (Mouse) Details: MAP2 antibody was used in IHC application for immunostaining of microtubule-associated protein 2 (a marker for neuronal dendrites) on whole-mount retinas at P23 of mice ( P23 Ptf1a-Cre R26^tdTomato/+ retinas). This staining depicted the colocalization of amacrine and horizontal cell neurites with the intraretinal vasculature (Figure 1 - H and -I).		Mouse
Schwerk A, Altschuler J, Roch M et al. Human adipose-derived mesenchymal stromal cells increase endogenous neurogenesis in the rat subventricular zone acutely after 6-hydroxydopamine lesioning. Cytotherapy. 2014-10-24 [PMID: 25457280] (IHC-Fr, Human) Details: MAP2/MAP2b antibody used as neuronal marker in IHC-Fr immunostaining the human adipose-derived mesenchymal stromal cells transplanted into the rat substantia nigra in the 6-hydroxydopamine model of Parkinson's disease	IHC-Fr	Human
Oenarto J, Gorg B, Moos M et al. Expression of organic osmolyte transporters in cultured rat astrocytes and rat and human cerebral cortex. Arch. Biochem. Biophys. 2014-07-05 [PMID: 25004465] (IHC-Fr, ICC/IF, Rat, Human) Details: MAP2 antibody used at 1:200 dilution for ICC-IF on cultured rat brain cells (Fig 2B) and for IHC-Fr on Rat / Human brain sections (Fig 4).	IHC-Fr, ICC/IF	Rat, Human
Khacho M, Tarabay M, Patten D et al. Acidosis overrides oxygen deprivation to maintain mitochondrial function and cell survival. Nat Commun 2014-04-01 [PMID: 24686499] (ICC/IF, Mouse)	ICC/IF	Mouse
Nieland Thomas J F, Logan David J, Saulnier Jessica et al. High content image analysis identifies novel regulators of synaptogenesis in a high-throughput RNAi screen of primary neurons. PLoS One. 2014-03-14 [PMID: 24633176] (ICC/IF, Mouse)	ICC/IF	Mouse
Sharma K, Choi SY, Zhang Y et al. High-Throughput Genetic Screen for Synaptogenic Factors: Identification of LRP6 as Critical for Excitatory Synapse Development. Cell Rep 2013-12-12 [PMID: 24316074] (ICC/IF, Mouse)	ICC/IF	Mouse
Liang CL, Marks GA, et al. GABAA receptors are located in cholinergic terminals in the nucleus pontis oralis of the rat: implications for REM sleep control. Brain Res. 2013-10-17 [PMID: 24141149] (ICC/IF, IF/IHC, Rat)	ICC/IF, IF/IHC	Rat
Abdullah H, Heaney LG, Cosby SL, McGarvey LP. Rhinovirus upregulates transient receptor potential channels in a human neuronal cell line: implications for respiratory virus-induced cough reflex sensitivity. Thorax. 2013-09-03 [PMID: 24002057]
Grant P, Ahlemeyer B, Karnati S et al. The biogenesis protein PEX14 is an optimal marker for the identification and localization of peroxisomes in different cell types, tissues, and species in morphological studies. Histochem Cell Biol. 2013-08-20 [PMID: 23959168] (ICC/IF)	ICC/IF
Chen Z, Cooper B, Kalla S et al. The Munc13 Proteins Differentially Regulate Readily Releasable Pool Dynamics and Calcium-Dependent Recovery at a Central Synapse. J Neurosci 2013-05-08 [PMID: 23658173] (ICC/IF, IHC-Fr, Mouse)	ICC/IF, IHC-Fr	Mouse
Nair R, Lauks J, Jung S et al. Neurobeachin regulates neurotransmitter receptor trafficking to synapses J Cell Biol 2012-12-31 [PMID: 23277425] (IF/IHC, ICC/IF, Mouse)	IF/IHC, ICC/IF	Mouse
Larson M, Sherman MA, Amar F et al. The Complex PrPc-Fyn Couples Human Oligomeric Abeta with Pathological Tau Changes in Alzheimer's Disease J Neurosci 2012-11-21 [PMID: 23175838] (ICC/IF, IF/IHC, Human)	ICC/IF, IF/IHC	Human
Colgan LA, Cavolo SL, Commons KG, Levitan ES. Action Potential-Independent and Pharmacologically Unique Vesicular Serotonin Release from Dendrites J Neurosci 2012-11-07 [PMID: 23136413] (ICC/IF, IF/IHC, Rat)	ICC/IF, IF/IHC	Rat
Scuderi C, Valenza M, Stecca C et al. Palmitoylethanolamide exerts neuroprotective effects in mixed neuroglial cultures and organotypic hippocampal slices via peroxisome proliferator-activated receptor-alpha J Neuroinflammation 2012-03-09 [PMID: 22405189] (ICC/IF, Rat)	ICC/IF	Rat
Sur S, Pashuck ET, Guler MO et al. A hybrid nanofiber matrix to control the survival and maturation of brain neurons. Biomaterials; 22018390]. 2011-10-19 [PMID: 22018390] (ICC/IF, Rat)	ICC/IF	Rat
Li Y, Serwanski DR, Miralles CP et al. Synaptic and nonsynaptic localization of protocadherin-gammaC5 in the rat brain. J Comp Neurol;518(17):3439-63. 2010-09-01 [PMID: 20589908] (ICC/IF, Human)	ICC/IF	Human
Amar F. Cellular And Molecular Mechanism Of Action Of The Amyloid-Beta Oligomer Abeta Star 56. Thesis. 2016-01-01
Chao HW, Lai YT, Lu YL et al. NMDAR signaling facilitates the IPO5-mediated nuclear import of CPEB3 Nucleic Acids Res 2012-06-22 [PMID: 22730302] (ICC/IF, Mouse, Rat)	ICC/IF	Mouse, Rat
Schatzle P, Wuttke R, Ziegler U, Sonderegger P. Automated quantification of synapses by fluorescence microscopy. Journal of Neuroscience Methods 11204(1):144-149. 2011-11-01 [PMID: 22108140] (ICC/IF, Mouse)	ICC/IF	Mouse
Show All 109 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
	5 reviewed by: Shashirekha Markandaiah	ICC	Human	12/08/2022	View Summary Application Immunocytochemistry Sample Tested human iPS cortical neurons Species Human Lot 7377-102022 Comments Comments Human iPS derived neurons labeled with MAP2 (in green) at 1:5000 dilution.
	5 reviewed by: Verified Customer	IHC-Fr	Feline	11/19/2022	View Summary Application Immunohistochemistry-Frozen Sample Tested Retina Species Feline Lot 7377-102022 Comments Comments ***Novus Innovators Program - new species or application used on a primary antibody.***
	5 reviewed by: Verified Customer	IHC-Fr	Mouse	07/29/2021	View Summary Application Immunohistochemistry-Frozen Sample Tested Astrocytes Species Mouse Lot D1
Enlarge	5 reviewed by: Karthik Krishnamurthy	ICC	Rat	11/01/2017	View Summary Application Immunocytochemistry Sample Tested Cultured motor neurons Species Rat Lot 7225-9 Comments Comments Used at a dilution of 1:2500. incubated at 4 degrees overnight. Robust staining
Enlarge	5 reviewed by: Lingling Yang	ICC	Mouse	11/22/2016	View Summary Application Immunocytochemistry Sample Tested Mouse primary cultures Species Mouse Comments Comments 1:1000 dilution
Enlarge	5 reviewed by: Verified Customer	IF	Human	01/22/2016	View Summary Application Immunofluorescence Sample Tested Rat and Human. Species Human
	5 reviewed by: Michael Olive	IHC-Fr	Rat	12/07/2010	View Summary Application Immunohistochemistry-Frozen Sample Tested Rat brain tissue Species Rat

Array NB300-213

• MAP2 Antibodies
• MAP2 ELISA Kits
• MAP2 Lysates
• MAP2 Proteins