MAP1B [p Thr1265] Antibody - SuperBUGS

MAP1B (microtubule-associated protein 1B) is the major cytoskeletal constituent of developing nervous system wherein it plays a key role in neuronal migration as well as differentiation. MAP1B interacts with LC1, ANP32A, TIAM2, GAN, DAPK1, tubulin tyrosine TTL etc. and binds at least two tubulin subunits in the polymer which is critical in nucleating microtubule polymerization as well as in stabilizing the microtubules. MAP1B is one of the major phosphorylation substrates for GSK-3beta which phosphorylates it at Ser1260/Thr1265 in differentiating neurons, a molecular switch for MAP1B mediated regulation of microtubule dynamics in the growing axons and the growth cones. MAP1B acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation/membrane blebbing and also brings about tyrosination of alpha-tubulin in neuronal microtubules along with its essential role in synaptic maturation. MAP1B is downstream of various signalling pathways that stimulate neurite growth or direct growth cone pathfinding, e.g. laminin, netrins, neurotrophins, wingless/integration site, or that influence neuronal migration, e.g. reelin. MAP1B is implicated in a number of neurological disorders, such as fragile X syndrome and giant axonal neuropathy.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 8 confirmed species: Human, Mouse, Rat, Chicken, Fish, Monkery, Reptile, Xenopus.

We have publications tested in 3 applications: ICC/IF, IHC-Fr, WB.

Showing Publications 1 - 8 of 8.

Publications using NBP1-42827	Applications	Species
Ketschek A, Jones S, Spillane M et al. Nerve growth factor promotes reorganization of the axonal microtubule array at sites of axon collateral branching Dev Neurobiol 2015-04-02 [PMID: 25846486] (ICC/IF, Chicken)	ICC/IF	Chicken
Ma QL, Zuo X, Yang F et al. Loss of MAP Function Leads to Hippocampal Synapse Loss and Deficits in the Morris Water Maze with Aging. J. Neurosci. 2014-05-21 [PMID: 24849348] (IHC-Fr, WB, Mouse)	IHC-Fr, WB	Mouse
Capoccia BJ, Jin RU, Kong YY et al. The ubiquitin ligase Mindbomb 1 coordinates gastrointestinal secretory cell maturation J Clin Invest 2013-04-01 [PMID: 23478405] (ICC/IF, Mouse, Human)	ICC/IF	Mouse, Human
Marchbank K, Waters S, Roberts RG et al. Marchbank K, Waters S, Roberts RG et al. MAP1B Interaction with the FW Domain of the Autophagic Receptor Nbr1 Facilitates Its Association to the Microtubule Network Int J Cell Biol 2012-05-10 [PMID: 22654911] (WB, Monkery) Details: Chlorocebus sabaeus (Green monkey)	WB	Monkery
Tymanskyj SR, Lin S, Gordon-Weeks PR. Evolution of the spatial distribution of MAP1B phosphorylation sites in vertebrate neurons. J Anat. 2010-04-09 [PMID: 20408908] (IHC-Fr, ICC/IF, WB, Xenopus, Reptile, Rat, Chicken, Fish)	IHC-Fr, ICC/IF, WB	Xenopus, Reptile, Rat, Chicken, Fish
Scales TM, Lin S, Kraus M, Goold RG, Gordon-Weeks PR. Nonprimed and DYRK1A-primed GSK3 beta-phosphorylation sites on MAP1B regulate microtubule dynamics in growing axons. J Cell Sci;122(Pt 14):2424-35. 2009-07-15 [PMID: 19549690] (IHC-Fr, WB, Rat)	IHC-Fr, WB	Rat
Trivedi N, Marsh P, Goold RG, Wood-Kaczmar A, Gordon-Weeks PR. Glycogen synthase kinase-3beta phosphorylation of MAP1B at Ser1260 and Thr1265 is spatially restricted to growing axons. J Cell Sci;118(Pt 5):993-1005. 2005-03-01 [PMID: 15731007] (IHC-Fr, WB, ICC/IF, Rat)	IHC-Fr, WB, ICC/IF	Rat
Pimentel HI da CA. Glycogen synthase kinase 3[beta] modulation in axonal regeneration. 2011 Universidade de Aveiro. 2011-01-01

Array NBP1-42827

• MAP1B Antibodies
• MAP1B Protein