Snail Antibody - BSA Free

Snail, also called SNAIL1 or SNAI1, is a zinc-finger transcription factor belonging to the Snail superfamily and encoded by the SNAI1 gene (1,2). Snail was first discovered in Drosophila and has homologs in many species including vertebrates and humans (1,2). The Snail family members includes Snail (Snail1), Slug (Snail2), and Smuc (Snail3) (1,2). In humans, Snail is expressed in a number of tissues including placenta, brain, and skeletal muscle, but is most highly expressed by the kidneys (1). Snail functions in repression of E-cadherin transcription which is associated with epithelial-mesenchymal transition (EMT) that is especially prominent during embryonic development (1-5). Along with Snail, other related EMT-inducing transcription factors (EMT-TFs) include the Twist and ZEB protein families (3). Snail is synthesized as a protein of 264 amino acids (aa) with an N-terminal SNAG domain, a serine-rich domain (SRD), nuclear export sequences (NES), and four C-terminal zinc-finger binding domains, with a theoretical molecular weight of 29 kDa (1,3). Snail activity is largely regulated through post-translational modifications such as phosphorylation, ubiquitination, and glycosylation, which impacts Snail's localization and stability, amongst other things (1-3, 5).

In addition to its role in embryonic development, Snail-induced EMT is also associated with cancer metastasis (1-5). Snail is expressed in a variety of cancer lines including breast cancer, cervical carcinoma, and colorectal carcinoma, and typically results in increased migration, invasion, and metastasis (1). Accordingly, Snail expression is also correlated with drug resistance and tumor recurrence (1-5). Chemical inhibitors that target Snail have shown some promise in reducing or eliminating Snail-induced EMT, increasing E-cadherin expression, and increasing tumor regression (1).

1. Kaufhold, S., & Bonavida, B. (2014). Central role of Snail1 in the regulation of EMT and resistance in cancer: a target for therapeutic intervention. Journal of Experimental & Clinical Cancer Research. https://doi.org/10.1186/s13046-014-0062-0

2. Wang, Y., Shi, J., Chai, K., Ying, X., & Zhou, B. P. (2013). The Role of Snail in EMT and Tumorigenesis. Current Cancer Drug Targets. https://doi.org/10.2174/15680096113136660102

3. Kang, E., Seo, J., Yoon, H., & Cho, S. (2021). The Post-Translational Regulation of Epithelial-Mesenchymal Transition-Inducing Transcription Factors in Cancer Metastasis. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms22073591

4. Seo, J., Ha, J., Kang, E., & Cho, S. (2021). The role of epithelial-mesenchymal transition-regulating transcription factors in anti-cancer drug resistance. Archives of Pharmacal Research. https://doi.org/10.1007/s12272-021-01321-x

5. Baulida, J., Diaz, V. M., & Herreros, A. G. (2019). Snail1: A Transcriptional Factor Controlled at Multiple Levels. Journal of Clinical Medicine. https://doi.org/10.3390/jcm8060757

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 5 applications: ICC/IF, IF/IHC, IHC-P, Simple Western, WB.

Showing Publications 1 - 10 of 11. Show All 11 Publications. Collapse Publications.

Publications using NBP2-27293	Applications	Species
Zhu X, Lu J, Rao J et al. Cross Talk between ST2 and Transforming Growth Factor-? Receptor Signaling Promotes Renal Fibrosis The American journal of pathology 2023-05-24 [PMID: 37236504]
Bychkov, ML;Kirichenko, AV;Mikhaylova, IN;Paramonov, AS;Yastremsky, EV;Kirpichnikov, MP;Shulepko, MA;Lyukmanova, EN; Extracellular Vesicles Derived from Acidified Metastatic Melanoma Cells Stimulate Growth, Migration, and Stemness of Normal Keratinocytes Biomedicines [PMID: 35327461] (WB, Human)	WB	Human
Jin JQ, Han JS, Ha J Et al. Lobeglitazone, A Peroxisome Proliferator-Activated Receptor-Gamma Agonist, Inhibits Papillary Thyroid Cancer Cell Migration and Invasion by Suppressing p38 MAPK Signaling Pathway Endocrinology and metabolism (Seoul, Korea) 2021-10-01 [PMID: 34645125] (WB, Human)	WB	Human
Lu R, Zhou Q, Ju L Et Al. Upregulation of TRIP13 promotes the malignant progression of lung cancer via the EMT pathway Oncology reports 2021-08-01 [PMID: 34184074] (WB)	WB
Meng L, Yue X, Zhou D, Li H Long non coding RNA OIP5 AS1 promotes metastasis of breast cancer via miR 340 5p/ZEB2 axis Oncol Rep 2020-08-10 [PMID: 32945479] (WB, Human)	WB	Human
Ponandai-Srinivasan S, Saare M, et al. Syndecan-1 modulates the invasive potential of endometrioma via TGF-beta signalling in a subgroup of women with endometriosis. Hum Reprod 2020-10-01 [PMID: 32897364] (Simple Western)	Simple Western
Huang D, Duan H, Huang H et al. Cisplatin resistance in gastric cancer cells is associated with HER2 upregulation-induced epithelial-mesenchymal transition. Sci Rep 2016-02-05 [PMID: 26846307] (WB, IHC-P, Human)	WB, IHC-P	Human
Abrahamsson A, Rasti Boroojeni F, Naeimipour S et al. Matrix Stiffness Enhances Pro-Tumorigenic Traits of ER-Positive but not ER-Negative Breast Cancer in a Physiologically Relevant 3D Model SSRN 2023-08-17 (ICC/IF, Human)	ICC/IF	Human
He C, Plattner R, Rangnekar V et al. Potential protein markers for breast cancer recurrence: a retrospective cohort study. Cancer Causes Control. 2018-11-28 [PMID: 30488343] (IF/IHC, Human)	IF/IHC	Human
Wu J, Zhang Y, Cheng R et al. Expression of EMT regulators TWIST, SLUG, and SNAIL in follicular thyroid tumours may relate to widely invasive, poorly differentiated, and distant metastasis. Histopathology. 2018-10-28 [PMID: 30368884] (IF/IHC, Human)	IF/IHC	Human
Wang Y, Sun J, Wei X et al. Decrease of miR-622 expression suppresses migration and invasion by targeting regulation of DYRK2 in colorectal cancer cells. Onco Targets Ther. 2017-03-06 [PMID: 28260923] (WB, Human)	WB	Human
Show All 11 Publications. Collapse Publications.

Array NBP2-27293

• Snail Antibodies
• Snail Lysate
• Snail Proteins