Recombinant Mouse CD14 Fc Chimera Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

CD14 is a 55 kDa cell surface glycoprotein that is preferentially expressed on monocytes/macrophages. The mouse CD14 cDNA encodes a 366 amino acid (aa) residue precursor protein with a 15 aa signal peptide and a C-terminal hydrophobic region characteristic for glycosylphosphatidyinositol (GPI)-anchored proteins. Mouse CD14 has five potential N-linked glycosylation sites and also bears O-linked carbohydrates. The amino acid sequence of mouse CD14 is approximately 65% and 82% identical to the human and rat proteins, respectively. CD14 is a pattern recognition receptor that binds lipopolysaccharides (LPS) and a variety of ligands derived from different microbial sources. The binding of CD14 with LPS is catalyzed by LPS-binding protein (LBP). The toll-like-receptors have also been implicated in the transduction of CD14-LPS signals. Similar to other GPI-anchored proteins, soluble CD14 can be released from the cell surface by phosphatidyinositol-specific phospholipase C. Soluble CD14 has been detected in serum and body fluids. High concentrations of soluble CD14 have been shown to inhibit LPS-mediated responses. However, soluble CD14 can also potentiate LPS response in cells that do not express cell surface CD14.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 5 applications: Binding Assay, Bioassay, ELISA Developmet, Enzyme Assay, In Vivo.

Showing Publications 1 - 6 of 6.

Publications using 982-CD	Applications	Species
V Barbier, J Erbani, C Fiveash, JM Davies, J Tay, MR Tallack, J Lowe, JL Magnani, DR Pattabiram, AC Perkins, J Lisle, JEJ Rasko, JP Levesque, IG Winkler Endothelial E-selectin inhibition improves acute myeloid leukaemia therapy by disrupting vascular niche-mediated chemoresistance Nat Commun, 2020-04-27;11(1):2042. 2020-04-27 [PMID: 32341362] (Bioassay, Mouse)	Bioassay	Mouse
N Okamoto, K Mizote, H Honda, A Saeki, Y Watanabe, T Yamaguchi-, R Fukui, N Tanimura, Y Motoi, S Akashi-Tak, T Kato, S Fujishita, T Kimura, U Ohto, T Shimizu, T Hirokawa, K Miyake, K Fukase, Y Fujimoto, Y Nagai, K Takatsu Funiculosin variants and phosphorylated derivatives promote innate immune responses via the Toll-like receptor 4/myeloid differentiation factor-2 complex J. Biol. Chem., 2017-07-28;0(0):. 2017-07-28 [PMID: 28754693] (Bioassay, Mouse)	Bioassay	Mouse
R Biedro?, A Peru?, S Józefowski CD36 Differently Regulates Macrophage Responses to Smooth and Rough Lipopolysaccharide PLoS ONE, 2016-04-13;11(4):e0153558. 2016-04-13 [PMID: 27073833] (Enzyme Assay, Mouse)	Enzyme Assay	Mouse
Hong C, Qiu X, Li Y Functional analysis of recombinant calreticulin fragment 39-272: implications for immunobiological activities of calreticulin in health and disease. J. Immunol., 2010-09-20;185(8):4561-9. 2010-09-20 [PMID: 20855873] (ELISA Developmet, Mouse)	ELISA Developmet	Mouse
Brass DM, Hollingsworth JW, McElvania-TeKippe E, Garantziotis S, Hossain I, Schwartz DA CD14 is an essential mediator of LPS-induced airway disease. Am. J. Physiol. Lung Cell Mol. Physiol., 2007-03-23;293(1):L77-83. 2007-03-23 [PMID: 17384086] (In Vivo, Mouse)	In Vivo	Mouse
Bate C, Kempster S, Williams A Prostaglandin D2 mediates neuronal damage by amyloid-beta or prions which activates microglial cells. Neuropharmacology, 2005-11-11;50(2):229-37. 2005-11-11 [PMID: 16289250] (Binding Assay, Mouse)	Binding Assay	Mouse

Array 982-CD

• CD14 Antibodies
• CD14 Antibody Pair
• CD14 Lysates
• CD14 Proteins
• CD14 ELISAs
• CD14 Proteins and Enzymes