PCBP2 Antibody (5F12)

This product is produced by and distributed for Abnova, a company based in Taiwan.

The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly(rC)-binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES, promoting poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1, an intronless gene with functions similar to that of PCBP2. This gene and PCBP-1 have paralogous genes (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. Thsi gene also has two processed pseudogenes (PCBP2P1 and PCBP2P2). Multiple transcript variants encoding several different isoforms have been found for this gene, but the full-length nature of only three have been characterized to date.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 3 applications: Immunohistochemistry, WB, Western Blot.

Showing Publications 1 - 10 of 18. Show All 18 Publications. Collapse Publications.

Publications using H00005094-M07	Applications	Species
Hiroyuki H, Motoi Y, Hajime A et al. Mutated FUS in familial amyotrophic lateral sclerosis involves multiple hnRNPs in the formation of neuronal cytoplasmic inclusions. J Neuropathol Exp Neurol. 2023-01-02 [PMID: 36592411]
Motoi Y, Hiroyuki H, Naokazu S et al. PCBP2 Is Downregulated in Degenerating Neurons and Rarely Observed in TDP-43-Positive Inclusions in Sporadic Amyotrophic Lateral Sclerosis. J Neuropathol Exp Neurol. 2020-12-14 [PMID: 33313661]
Davidson YS, Robinson AC, Flood L et al. Heterogeneous ribonuclear protein E2 (hnRNP E2) is associated with TDP-43-immunoreactive neurites in Semantic Dementia but not with other TDP-43 pathological subtypes of Frontotemporal Lobar Degeneration Acta Neuropathologica Communications 2017-12-01 [PMID: 28666471] (Immunohistochemistry, Western Blot)	Immunohistochemistry, Western Blot
Yanatori I, Richardson DR, Toyokuni S, Kishi F. The Iron Chaperone Poly (rC)-binding Protein 2 Forms a Metabolon with the Heme Oxygenase 1/Cytochrome P450 Reductase Complex for Heme Catabolism and Iron Transfer J. Biol. Chem. 2017-06-27 [PMID: 28655775]
Roth H, Magg V, Uch F et al. Flavivirus Infection Uncouples Translation Suppression from Cellular Stress Responses. MBio 2017-01-10 [PMID: 28074025]
Yanatori I, Richardson DR, Imada K, Kishi F. Iron Export through the Transporter Ferroportin 1 Is Modulated by the Iron Chaperone PCBP2. J Biol Chem 2016-08-12 [PMID: 27302059]
Li F, Bullough KZ, Vashisht AA et al. Poly(rC)-Binding Protein 2 Regulates Hippo Signaling To Control Growth in Breast Epithelial Cells. Mol Cell Biol 2016-05-23 [PMID: 27215387]
Bradley G, Charles W, Younghee K et al. Iron Toxicity in the Retina Requires Alu RNA and the NLRP3 Inflammasome. Cell Rep. 2015-06-11 [PMID: 26074074]
Li Y, Masaki T, Shimakami T, Lemon SM. hnRNP L and NF90 interact with hepatitis C virus 5' terminal untranslated RNA and promote efficient replication. J Virol. 2014-04-09 [PMID: 24719423]
Ho JJ, Robb GB, Tai SC et al. Active stabilization of the human eNOS mRNA by hnRNP E1 protects against antisense RNA and microRNAs Mol Cell Biol 2013-03-11 [PMID: 23478261] (WB, Human)	WB	Human
Fujimura K, Sasaki AT, Anderson P. Selenite targets eIF4E-binding protein-1 to inhibit translation initiation and induce the assembly of non-canonical stress granules. Nucleic Acids Res. 2012-06-20 [PMID: 22718973]
Nandal A, Ruiz JC, Subramanian P, Ghimire-Rijal S, Sinnamon RA, Stemmler TL, Bruick RK, Philpott CC. Activation of the HIF prolyl hydroxylase by the iron chaperones PCBP1 and PCBP2. Cell Metab;14(5):647-57. 2011-11-02 [PMID: 22055506] (WB, Human)	WB	Human
Wang L, Jeng KS, Lai MM. Poly(C)-binding protein 2 Interacts with sequences Required for Viral Replication in HCV 5' UTR and Directs HCV RNA Replication through Circularizing the Viral Genome. J Virol. 2011-06-01 [PMID: 21632751]
Lawrence P, Rieder E. Identification of RNA helicase A as a new host factor in the replication cycle of foot-and-mouth disease virus. J Virol 2009-11-01 [PMID: 19710149]
Fujimura K, Katahira J, Kano F et al. Selective localization of PCBP2 to cytoplasmic processing bodies. Biochim Biophys Acta. 2009-02-18 [PMID: 19230839]
Subeta C, Czupalla C, Winter C et al. Rapid changes of mRNA binding protein levels following glucose IBMX stimulation of insulinoma INS-1 cells. Mol Cell Proteomics 8(3):393-408. 2009-03-01 [PMID: 18854578]
Ghosh D, Srivastava GP, Xu D et al. A link between SIN1 (MAPKAP1) poly(rC) binding protein 2 (PCBP2) in counteracting environmental stress. PNAS;105(33):11673-11678. 2008-01-01 [PMID: 18687895]
Fujimura K, Kano F, Murata M. Identification of PCBP2, a facilitator of IRES-mediated translation, as a novel constituent of stress granules processing bodies. RNA;14(3):425-31. 2008-03-01 [PMID: 18174314]
Show All 18 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
	3 reviewed by: Verified Customer	WB	Human	02/24/2010	View Summary Application Western Blot Sample Tested human liver cells, Sample Amount: 15 ug Species Human

Array H00005094-M07

• PCBP2 Antibodies
• PCBP2 Lysates
• PCBP2 Proteins