PCBP1 Antibody (1G2)

This product is produced by and distributed for Abnova, a company based in Taiwan.

This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: WB.

Showing Publications 1 - 6 of 6.

Publications using H00005093-M01	Applications	Species
Simon G, Cecile F, Clemence O et al. TGF?-induced expression of long noncoding lincRNA Platr18 controls breast cancer axonogenesis. Life Sci Alliance. 2021-11-22 [PMID: 34810279]
Woosley AN, Dalton AC, Hussey GS et al. TGF beta promotes breast cancer stem cell self-renewal through an ILEI/LIFR signaling axis. Oncogene. 2019-01-28 [PMID: 30692635]
Howley BV, Link LA, Grelet S et al. A CREB3-regulated ER-Golgi trafficking signature promotes metastatic progression in breast cancer. Oncogene 2017-12-18 [PMID: 29249802]
Link LA, Howley BV, Hussey GS, Howe PH PCBP1/HNRNP E1 Protects Chromosomal Integrity by Translational Regulation of CDC27. Mol Cancer Res 2016-07-01 [PMID: 27102006]
Song Q, Sheng W, Zhang X et al. ILEI drives epithelial to mesenchymal transition and metastatic progression in the lung cancer cell line A549. Tumour Biol. 2013-09-27 [PMID: 24072492]
Hussey GS, Link LA, Brown AS et al. Establishment of a TGFbeta-Induced Post-Transcriptional EMT Gene Signature PLoS One 2012-01-01 [PMID: 23285117] (WB, Mouse)	WB	Mouse

Array H00005093-M01

• PCBP1 Antibodies
• PCBP1 Lysate
• PCBP1 Proteins