Notch-3 Antibody (603532) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Human Notch-3 is a member of the Notch family of type I transmembrane glycoproteins involved in early-event developmental processes. The 2321 amino acid (aa) Notch-3 precursor contains a 1603 aa extracellular region with 34 EGF-like repeats. Repeats 1-11 of human Notch-3 are within the sequence used as an immunogen, and share 94% aa identity with mouse and rat Notch-3. Repeats 11 and 12 are critical for binding the ligands Jagged and Delta. Notch-3 is expressed in vascular smooth muscle, proliferating neuroepithelium, CD4^-CD8^- thymocytes, regulatory T cells and T-ALL leukemia cells. Mutations in the first 5 EGF repeats of Notch-3 in humans can cause CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 3 applications: ELISA Capture, Flow Cytometry, IHC.

Showing Publications 1 - 4 of 4.

Publications using MAB1559	Applications	Species
DV Oliveira, KG Coupland, W Shao, S Jin, F Del Gaudio, S Wang, R Fox, JW Rutten, J Sandin, H Zetterberg, J Lundkvist, SA Lesnik Obe, U Lendahl, H Karlström Active immunotherapy reduces NOTCH3 deposition in brain capillaries in a CADASIL mouse model Embo Molecular Medicine, 2022-12-16;0(0):e16556. 2022-12-16 [PMID: 36524456] (ELISA Capture, Mouse)	ELISA Capture	Mouse
H Kim, B Jang, YJ Kim, JC Choi Determination of Blood NOTCH3 Extracellular Domain and Jagged-1 Levels in Healthy Subjects International Journal of Molecular Sciences, 2022-09-11;23(18):. 2022-09-11 [PMID: 36142458] (ELISA Capture, Human)	ELISA Capture	Human
Machuca-Parra AI, Bigger-Allen AA, Sanchez AV et al. Therapeutic antibody targeting of Notch3 signaling prevents mural cell loss in CADASIL J. Exp. Med. 7/11/2017 [PMID: 28698285]
Soriani A, Iannitto M, Ricci B, Fionda C, Malgarini G, Morrone S, Peruzzi G, Ricciardi M, Petrucci M, Cippitelli M, Santoni A Reactive oxygen species- and DNA damage response-dependent NK cell activating ligand upregulation occurs at transcriptional levels and requires the transcriptional factor E2F1. J Immunol, 2014-06-09;193(2):950-60. 2014-06-09 [PMID: 24913980] (Flow Cytometry, IHC, Human)	Flow Cytometry, IHC	Human

Array MAB1559

• Notch-3 Antibodies
• Notch-3 Protein
• Notch-3 Proteins and Enzymes