KLRG1 Antibody (697213)

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

KLRG1 (killer cell lectin-like receptor G1), also known as MAFA (mast cell function associated), is a 30-38 kDa type II transmembrane inhibitory glycoprotein of the C‑type lectin family, designated CLEC15A. KLRG1 cDNA encodes 195 amino acids (aa) including an intracellular ITIM motif and a 136 aa extracellular domain (ECD) with a single C-type lectin domain. The human KLRG1 ECD shares 57% and 54% aa identity with mouse and rat KLRG1, respectively. A 189 aa isoform diverges at aa 186. KLRG1 binds E-, N- and R-cadherins and functions as an MHC-independent means of identifying non-self pathogens and epithelial tumor cells with low E-cadherin expression. It is expressed as a monomer or disulfide-linked homodimer on NK and T cell subsets such as tumor-infiltrating lymphocytes.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Array MAB70291

• KLRG1 Antibodies
• KLRG1 Lysate
• KLRG1 Proteins
• KLRG1 Proteins and Enzyme