HRD1 Antibody - BSA Free

HRD1 (synovial apoptosis inhibitor 1 or SYVN1) is a ubiquitin ligase whose expression is induced by UPR following ER stress and it provides protection to cells from apoptosis by inducing degradation of abnormally processed proteins that accumulate in ER. HRD1 acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from ER-associated UBC7 E2 ligase and transfers it to target proteins for promoting their degradation. It is a component of ER's quality control system called ERAD (ER-associated degradation) which is involved in ubiquitin-dependent degradation of misfolded ER proteins. HRD1 also facilitates the degradation of normal/naturally short-lived proteins such as SGK, and has been shown to protect neuronal cells from apoptosis triggered by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by prooting their degradation. Moreover, HRD1 sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 4 applications: IHC, IHC-P, IP, WB.

Showing Publications 1 - 10 of 14. Show All 14 Publications. Collapse Publications.

Publications using NB100-2526	Applications	Species
Lee ES, Aryal YP, Kim TY et al. The effects of 4-Phenylbutyric acid on ER stress during mouse tooth development Frontiers in Physiology 2023-01-04 [PMID: 36685173] (IHC)	IHC
Lee E, Aryal Y, Kim T et al. Facilitation of Reparative Dentin Using a Drug Repositioning Approach With 4-Phenylbutric Acid Front Physiol 2022-05-23 [PMID: 35600310]
Binder P, Nguyen B, Collins L et al. Pak2 Regulation of Nrf2 Serves as a Novel Signaling Nexus Linking ER Stress Response and Oxidative Stress in the Heart Frontiers in cardiovascular medicine 2022-03-08 [PMID: 35350536] (IP)	IP
Seidel E, Dassa L, Kahlon S et al. A slowly cleaved viral signal peptide acts as a protein-integral immune evasion domain Nature communications 2021-04-06 [PMID: 33824318] (WB, Human)	WB	Human
Jiang LL, Zhu B, Zhao Y et al. Membralin deficiency dysregulates astrocytic glutamate homeostasis leading to ALS-like impairment J. Clin. Invest. 2019-05-21 [PMID: 31112137] (IHC-P, Human, Mouse)	IHC-P	Human, Mouse
Xie H, Tang CA, Song JH, Mancuso A. IRE1a RNase-dependent lipid homeostasis promotes survival in Myc-transformed cancers. J. Clin. Invest. 2018-02-26 [PMID: 29381485] (WB, Human)	WB	Human
Hwang J, Walczak CP, Shaler TA et al. Characterization of protein complexes of the endoplasmic reticulum associated degradation E3 ubiquitin ligase Hrd1. J. Biol. Chem. 2017-04-14 [PMID: 28411238] (WB, Human)	WB	Human
Sun S, Shi G, Sha H et al. IRE1alpha is an endogenous substrate of endoplasmic-reticulum-associated degradation. Nat Cell Biol 2015-12-01 [PMID: 26551274] (WB)	WB
Koenig Pa, Nicholls Pk, Schmidt Fi et al. The E2 Ubiquitin Conjugating Enzyme UBE2J1 is Required for Spermiogenesis in Mice. J. Biol. Chem. 2014-10-15 [PMID: 25320092] (WB, Mouse)	WB	Mouse
Eshraghi A, Dixon SD, Tamilselvam B et al. Cytolethal Distending Toxins Require Components of the ER-Associated Degradation Pathway for Host Cell Entry PLoS Pathog. 2014-07-01 [PMID: 25078082]
Sun S, Shi G, Han X et al. Sel1L is indispensable for mammalian endoplasmic reticulum-associated degradation, endoplasmic reticulum homeostasis, and survival. Proc. Natl. Acad. Sci. U.S.A. 2014-02-05 [PMID: 24453213] (IHC-P, WB, Mouse)	IHC-P, WB	Mouse
Francisco AB, Singh R, Sha H et al. Haploid insufficiency of suppressor enhancer Lin12 1 like (SEL1L) predisposes mice to high fat diet-induced hyperglycemia. J Biol Chem;286(25):22275-82. 2011-06-24 [PMID: 21536682]
Dougan SK, Hu CC, Paquet ME et al. Derlin-2-deficient mice reveal an essential role for protein dislocation in chondrocytes Mol Cell Biol 2011-03-01 [PMID: 21220515] (WB, Mouse)	WB	Mouse
Soundararajan R, Wang J, Melters D, Pearce D. Glucocorticoid-induced Leucine zipper 1 stimulates the epithelial sodium channel by regulating serum- and glucocorticoid-induced kinase 1 stability and subcellular localization. J Biol Chem 2010-12-17 [PMID: 20947508] (WB, Human)	WB	Human
Show All 14 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Verified Customer	WB	Human	04/04/2020	View Summary Application Western Blot Sample Tested AR42J human acinar pancreatic cancer cell line,RKO Species Human Lot A-2
Enlarge	5 reviewed by: Verified Customer	WB	Human	11/06/2018	View Summary Application Western Blot Sample Tested 293T,MDA MB 231 cells Species Human Lot A-2
Enlarge	5 reviewed by: Verified Customer	WB	Human	10/17/2018	View Summary Application Western Blot Sample Tested 293T and HePG2 cell lysate Species Human Lot A-2

Array NB100-2526

• HRD1 Antibodies
• HRD1 Lysates
• HRD1 Proteins