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HRD1 Antibody [DyLight 755]

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Product Details

Summary
Reactivity Hu, Mu, HaSpecies Glossary
Applications WB, ICC/IF, IHC, IP, KO
Clonality
Polyclonal
Host
Rabbit
Conjugate
DyLight 755

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NB100-2526AF350
Alexa Fluor 405
NB100-2526AF405
Alexa Fluor 488
NB100-2526AF488
Alexa Fluor 532
NB100-2526AF532
Alexa Fluor 594
NB100-2526AF594
Alexa Fluor 647
NB100-2526AF647
Alexa Fluor 700
NB100-2526AF700
Alexa Fluor 750
NB100-2526AF750
Allophycocyanin
NB100-2526APC
Biotin
NB100-2526B
DyLight 350
NB100-2526UV
DyLight 405
NB100-2526V
DyLight 488
NB100-2526G
DyLight 550
NB100-2526R
DyLight 594
NB100-2526DL594
DyLight 650
NB100-2526C
DyLight 680
NB100-2526FR
FITC
NB100-2526F
HRP
NB100-2526H
Janelia Fluor 549
NB100-2526JF549
Janelia Fluor 646
NB100-2526JF646
PE
NB100-2526PE
PerCP
NB100-2526PCP
Unconjugated
NB100-2526
mFluor Violet 450 SE
NB100-2526MFV450
mFluor Violet 500 SE
NB100-2526MFV500
mFluor Violet 610 SE
NB100-2526MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NB100-2526
BSA Free
NB100-2526SS
BSA Free
NB100-2526
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HRD1 Antibody [DyLight 755] Summary

Immunogen
A synthetic peptide made to an internal portion of human HRD1 (within residues 300-400). [UniProt Q96PK3]
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
SYVN1
Purity
Unpurified
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Applications/Dilutions

Dilutions
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Immunoprecipitation
  • Knockout Validated
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

Hamster reactivity reported in scientific literature (PMID: 25078082).

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Unpurified

Notes



DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for HRD1 Antibody [DyLight 755]

  • E3 ubiquitin-protein ligase synoviolin
  • EC 6.3.2
  • HRD1EC 6.3.2.-
  • KIAA1810Synovial apoptosis inhibitor 1
  • MGC40372
  • synovial apoptosis inhibitor 1, synoviolin

Background

HRD1 is a ubiquitin ligase whose expression is induced by the unfolded protein response (UPR) following endoplasmic reticulum stress. Expression of HRD1 protects cells from apoptosis by inducing degradation of abnormally processed proteins that accumulate in the endoplasmic reticulum. HRD1 is expressed in many tissues, strongly expressed in brain, pancreas, liver, kidney and skeletal muscle. It has been reported that Synoviolin/Hrd1 (expressed in rheumatoid synovium) is a novel causative factor for arthropathy by triggering synovial cell outgrowth through its anti-apoptotic effects. HRD1 contains one ring-type zinc finger.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol SYVN1