Name: DARPP-32 Antibody (375604) [Unconjugated]
Brand: Novus Biologicals
SKU: MAB4230
Price: 429 USD

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At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

Reactivity	Mu, RtSpecies Glossary
Applications	WB, IHC
Clone	375604
Clonality	Monoclonal
Host	Rat
Conjugate	Unconjugated
Concentration	LYOPH

Immunogen	E. coli-derived recombinant human DARPP-32 Ala51-Thr204 Accession # Q9UD71.2
Specificity	Detects mouse and rat DARPP-32. Reactivity with human DARPP-32 has not been tested.
Source	N/A
Isotype	IgG2a
Clonality	Monoclonal
Host	Rat
Gene	PPP1R1B
Purity Statement	Protein A or G purified from hybridoma culture supernatant
Innovator's Reward	Test in a species/application not listed above to receive a full credit towards a future purchase. Learn about the Innovator's Reward

Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer	Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative	No Preservative
Concentration	LYOPH
Reconstitution Instructions	Reconstitute at 0.5 mg/mL in sterile PBS.

Publications using MAB4230	Applications	Species
Singh, V;Menard, MA;Serrano, GE;Beach, TG;Zhao, HT;Riley-DiPaolo, A;Subrahmanian, N;LaVoie, MJ;Volpicelli-Daley, LA; Cellular and subcellular localization of Rab10 and phospho-T73 Rab10 in the mouse and human brain Acta neuropathologica communications 2023-12-18 [PMID: 38110990] (Immunohistochemistry, Mouse)	Immunohistochemistry	Mouse
Mansky RH, Greguske EA, Yu D et al. Tumor suppressor p53 regulates heat shock factor 1 protein degradation in Huntington's disease Cell reports 3/2/2023 [PMID: 36867535]
L Duvick, WM Southern, K Benzow, HP Handler, JS Mitchell, H Kuivinen, UK Gadiparthi, P Yang, A Soles, C Scheeler, O Rainwater, S Shannah, E Larson, T Nichols-Me, Y You, B Oâ Callagh, HY Zoghbi, JM Ervasti, M Cvetanovic, MD Koob, HT Orr Regional vulnerability in a neurodegenerative disease: Delineating SCA1 CNS and muscle therapeutic targets using a conditional mutant ATXN1 mouse bioRxiv : the preprint server for biology, 2023-04-11;0(0):. 2023-04-11 [PMID: 36798410] (Western Blot, Mouse)	Western Blot	Mouse
Colleen S. Stein, Jared M. McLendon, Nathan H. Witmer, Ryan L. Boudreau Modulation of miR-181 influences dopaminergic neuronal degeneration in a mouse model of Parkinson’s disease Molecular Therapy - Nucleic Acids 6/14/2022 [PMID: 35280925]
M Derbis, E Kul, D Niewiadoms, M Sekrecki, A Piasecka, K Taylor, RK Hukema, O Stork, K Sobczak Short antisense oligonucleotides alleviate the pleiotropic toxicity of RNA harboring expanded CGG repeats Nature Communications, 2021-02-24;12(1):1265. 2021-02-24 [PMID: 33627639] (Western Blot, Mouse)	Western Blot	Mouse
ME Schmidt, NS Caron, AE Aly, FL Lemarié, L Dal Cengio, Y Ko, N Lazic, L Anderson, B Nguyen, LA Raymond, MR Hayden DAPK1 Promotes Extrasynaptic GluN2B Phosphorylation and Striatal Spine Instability in the YAC128 Mouse Model of Huntington Disease Front Cell Neurosci, 2020-11-05;14(0):590569. 2020-11-05 [PMID: 33250715] (ICC, Mouse)	ICC	Mouse
Machiela E, Jeloka R, Caron NS et al. The interaction of aging and oxidative stress contributes to pathogenesis in mouse and human Huntington disease neurons Front Aging Neurosci 11/16/2020 [PMID: 33192449]
Paulina Carriba, Sean Wyatt, Alun M. Davies CD40L Reverse Signaling Influences Dendrite Spine Morphology and Expression of PSD-95 and Rho Small GTPases Frontiers in Cell and Developmental Biology 4/28/2020 [PMID: 32411702]
CJ Burrus, SU McKinstry, N Kim, MI Ozlu, AV Santoki, FY Fang, A Ma, YB Karadeniz, AK Worthingto, I Dragatsis, S Zeitlin, HH Yin, C Eroglu Striatal Projection Neurons Require Huntingtin for Synaptic Connectivity and Survival Cell Rep, 2020-01-21;30(3):642-657.e6. 2020-01-21 [PMID: 31968243] (IHC, Mouse)	IHC	Mouse
NS Caron, AL Southwell, CC Brouwers, LD Cengio, Y Xie, HF Black, LM Anderson, S Ko, X Zhu, SJ van Devent, MM Evers, P Konstantin, MR Hayden Potent and sustained huntingtin lowering via AAV5 encoding miRNA preserves striatal volume and cognitive function in a humanized mouse model of Huntington disease Nucleic Acids Res., 2020-01-10;0(0):. 2020-01-10 [PMID: 31745548] (IHC, Mouse)	IHC	Mouse
ME Schmidt, C Buren, JP Mackay, D Cheung, L Dal Cengio, LA Raymond, MR Hayden Altering cortical input unmasks synaptic phenotypes in the YAC128 cortico-striatal co-culture model of Huntington disease BMC Biol., 2018-06-27;16(1):58. 2018-06-27 [PMID: 29945611] (ICC, Mouse)	ICC	Mouse
R Gomez-Past, ET Burchfiel, DW Neef, AM Jaeger, E Cabiscol, SU McKinstry, A Doss, A Aballay, DC Lo, SS Akimov, CA Ross, C Eroglu, DJ Thiele Abnormal degradation of the neuronal stress-protective transcription factor HSF1 in Huntington's disease Nat Commun, 2017-02-13;8(0):14405. 2017-02-13 [PMID: 28194040] (IHC, Mouse)	IHC	Mouse
Yehong Wan, Kristen K. Ade, Zachary Caffall, M. Ilcim Ilcim Ozlu, Cagla Eroglu, Guoping Feng et al. Circuit-Selective Striatal Synaptic Dysfunction in the Sapap3 Knockout Mouse Model of Obsessive-Compulsive Disorder Biological Psychiatry 4/15/2014 [PMID: 23414593]
Chen , Meng, Wan , Yehong, Ade , Kristen, Ting , Jonathan, Feng , Guoping, Calakos , Nicole Sapap3 deletion anomalously activates short-term endocannabinoid-mediated synaptic plasticity. J Neurosci, 2011-06-29;31(26):9563-73. 2011-06-29 [PMID: 21715621] (IHC, Mouse)	IHC	Mouse
Teegarden SL, Scott AN, Bale TL Early life exposure to a high fat diet promotes long-term changes in dietary preferences and central reward signaling. Neuroscience, 2009-05-22;162(4):924-32. 2009-05-22 [PMID: 19465087] (Western Blot, Mouse)	Western Blot	Mouse
Show All 15 Publications. Collapse Publications.

DARPP-32 Antibody (375604) [Unconjugated]

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Catalog# & Formulation	Size	Price
Carrier Free MAB4230-SP

Gene Symbol	PPP1R1B
Uniprot	Q9UD71.2()