BAG2 Antibody

BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner.BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Rat.

We have publications tested in 2 applications: ICC/IF, WB.

Showing Publications 1 - 3 of 3.

Publications using NBP1-59087	Applications	Species
Duggan MR, Mohseni Ahooyi T, Parikh V, Khalili K Neuromodulation of BAG co-chaperones by HIV-1 viral proteins and H2O2: implications for HIV-associated neurological disorders Cell death discovery 2021-03-26 [PMID: 33771978] (WB, Rat)	WB	Rat
Tan VP, Smith JM, Tu M et al. Dissociation of mitochondrial HK-II elicits mitophagy and confers cardioprotection against ischemia Cell Death Dis 2019-09-30 [PMID: 31570704] (ICC/IF, WB, Rat)	ICC/IF, WB	Rat
Gupta MK, Tahrir FG, Knezevic T et al. GRP78 Interacting Partner Bag5 Responds to ER Stress and Protects Cardiomyocytes from ER Stress-Induced Apoptosis. J. Cell. Biochem. 2016-01-05 [PMID: 26729625] (WB, Rat)	WB	Rat

Array NBP1-59087

• BAG2 Antibodies
• BAG2 Lysate
• BAG2 Proteins