BAK Products

Description

Bak a pro-apoptotic analog to Bax, is a member of the Bcl-2 family of proteins. During mitochondria-regulated programmed cell death, Bak promotes apoptosis by binding Bcl-2 and inhibiting its anti-apoptotic function (1). Upon apoptotic stimulation, Bak translocates from the cytosol to the mitochondrial membrane (2). Pro-apoptotic cascade activates BID, which oligomerizes Bak into pores that result in the release of cytochrome c (2, 3). In healthy cells, Bak associate with Bcl-xL and Mcl-1 but not with Bcl-2, Bcl-w or A1 and only when freed of both Bak will induce apoptosis.

Bioinformatics

Entrez	578 Human
Uniprot	AAH04431 Human AAH04431.1 Human NM_001188 Human NP_001179 Human NP_001179 Human NP_001179.1 Human Q16611 Human Q16611 Human
Product By Gene ID	578
Alternate Names	Apoptosis regulator BAK BAK-LIKE BAKMGC3887 BCL2-antagonist/killer 1 bcl2-L-7 Bcl2-L-7 BCL2L7bcl-2 homologous antagonist/killer BCL2-like 7 protein Bcl-2-like protein 7 CDN1 MGC117255 pro-apoptotic protein BAK

Research Areas for BAK

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Tumor Suppressors

Related BAK Blog Posts

Check out the latest blog posts on BAK.

IRE1 alpha dependent apoptotic-signaling pathway Despite in depth characterization of the role of IRE1 alpha (inositol-requiring enzyme 1 alpha) in activating the unfolded protein response (UPR) in the ER - little is known about the molecular mechanisms by which this ER protein has shown to reg...    Read more.

Dynamin-related Protein 1 (DRP1) in Mitochondria and Apoptosis. Dynamin-related Protein 1 (DRP1) is known to function in mitochondrial and peroxisomal division and mediate membrane fission through oligomerization into ring-like structure and sever the mitochondrial membrane, through a GTP hydrolysis-dependent mech...    Read more.

p53 - Investigating an important tumor suppressor p53 is a tumor suppressor that has a central role in regulating cell cycle arrest, DNA repair, and apoptosis. p53 is widely studied for its role in cancer and is mutated or altered in more than half of all cancers (1). This widespread role in tumor...    Read more.

Read more BAK related blogs.