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BAK L to A BH3 Synthetic Peptide GQVGRQAAIIGDDINR, CF

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications Inhibition Activity
Format
Carrier-Free

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BAK L to A BH3 Synthetic Peptide GQVGRQAAIIGDDINR, CF Summary

Accession #
N-terminal Sequence
Gly72
Protein/Peptide Type
Recombinant Proteins
Gene
BAK1

Applications/Dilutions

Dilutions
  • Inhibition Activity
Theoretical MW
1.7 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Publications
Read Publication using
879-BK in the following applications:

Packaging, Storage & Formulations

Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Reconstitution Instructions
Reconstitute in 20 μL of DMSO to obtain a 3.0  mM concentration.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for BAK L to A BH3 Synthetic Peptide GQVGRQAAIIGDDINR, CF

  • Apoptosis regulator BAK
  • BAK
  • BAK1
  • BAK-LIKE
  • BAKMGC3887
  • BCL2-antagonist/killer 1
  • BCL2L7
  • bcl2-L-7
  • BCL2L7bcl-2 homologous antagonist/killer
  • BCL2-like 7 protein
  • Bcl-2-like protein 7
  • CDN1
  • MGC117255
  • pro-apoptotic protein BAK

Background

Bcl-2-antagonist/killer (BAK), also known as BAK1 and Bcl-2-like Protein 7, is a proaptoptotic member of the Bcl-2 protein family with a predicted molecular weight of approximately 23 kDa. It contains four Bcl-2 homology domains, BH1-BH4, and a C-terminal transmembrane domain. Human BAK shares 77% amino acid sequence identity with the mouse and rat orthologs. BAK primarily localizes to the outer mitochondrial membrane where it is redundantly required, along with Bax, for the release of Cytochrome c during apoptosis. Cytochrome c release may occur through pores formed by homo-oligomerization of BAK within the mitochondrial outer membrane. BAK can be directly activated by BID, BIM, and PUMA, which are also members of the Bcl-2 family. Additionally, p53 can directly activate BAK in response to cell stress. BAK may also be involved in crosstalk between the apoptosis and autophagy pathways.

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Publications for BAK (879-BK)(1)

We have publications tested in 1 confirmed species: Rat.

We have publications tested in 1 application: In Vivo.


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Bioinformatics

Gene Symbol BAK1
Uniprot