VEGF Antibody [Biotin] - 164

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Vascular Endothelial Growth Factor (VEGF or VEGF-A), also known as Vascular Permeability Factor (VPF), is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. It is a member of the PDGF family that is characterized by the presence of eight conserved cysteine residues and a cystine knot structure. VEGF164 appears to be the most abundant and potent isoform, followed by VEGF120 and VEGF188. Mouse VEGF164 is an approximately 50 kDa molecular weight homodimer sharing 97% aa sequence identity with corresponding regions of rat, 89% with human and porcine, 90% with feline, equine and canine, and 88% with bovine VEGF, respectively. VEGF binds the type I transmembrane receptor tyrosine kinases VEGF R1 (also called Flt-1) and VEGF R2 (Flk-1/KDR) on endothelial cells. Although VEGF affinity is highest for binding to VEGF R1, VEGF R2 appears to be the primary mediator of VEGF angiogenic activity. Human VEGF165 binds the Semaphorin receptor, Neuropilin-1 and promotes complex formation with VEGF R2. VEGF is required during embryogenesis and functions to regulate the proliferation, migration, and survival of endothelial cells. In adults, VEGF functions mainly in wound healing and the female reproductive cycle. Pathologically, it is involved in tumor angiogenesis and vascular leakage. Circulating VEGF levels correlate with disease activity in autoimmune diseases such as rheumatoid arthritis, multiple sclerosis and systemic lupus erythematosus. VEGF is induced by hypoxia and cytokines such as IL-1, IL-6, IL-8, Oncostatin M (OSM) and TNF-alpha.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 5 applications: ELISA Detection, ELISA Development, ELISA Development (Capture), Flow Cytometry, Luminex Development.

Showing Publications 1 - 9 of 9.

Publications using BAF493	Applications	Species
A Yaguchi, M Oshikawa, G Watanabe, H Hiramatsu, N Uchida, C Hara, N Kaneko, K Sawamoto, T Muraoka, I Ajioka Efficient protein incorporation and release by a jigsaw-shaped self-assembling peptide hydrogel for injured brain regeneration Nature Communications, 2021-11-19;12(1):6623. 2021-11-19 [PMID: 34799548] (ELISA Detection, Mouse)	ELISA Detection	Mouse
JR Lee, I Appelmann, C Miething, TO Shultz, D Ruderman, D Kim, P Mallick, SW Lowe, SX Wang Longitudinal Multiplexed Measurement of Quantitative Proteomic Signatures in Mouse Lymphoma Models Using Magneto-Nanosensors Theranostics, 2018-02-03;8(5):1389-1398. 2/3/2018 [PMID: 29507628]
Jung-Rok Lee, Noriyuki Sato, Daniel J. B. Bechstein, Sebastian J. Osterfeld, Junyi Wang, Adi Wijaya Gani et al. Experimental and theoretical investigation of the precise transduction mechanism in giant magnetoresistive biosensors Scientific Reports 1/5/2016 [PMID: 26728870]
Sprague L, Muccioli M, Pate M, Singh M, Xiong C, Ostermann A, Niese B, Li Y, Li Y, Courreges M, Benencia F Dendritic cells: In vitro culture in two- and three-dimensional collagen systems and expression of collagen receptors in tumors and atherosclerotic microenvironments. Exp Cell Res, 2014-02-22;323(1):7-27. 2014-02-22 [PMID: 24569142] (ELISA Development (Capture), Mouse)	ELISA Development (Capture)	Mouse
Jacob Osterbur, Leslee Sprague, Maria Muccioli, Michelle Pate, Kristen Mansfield, John McGinty et al. Adhesion to substrates induces dendritic cell endothelization and decreases immunological response Immunobiology 1/1/2013 [PMID: 22551928]
Zhang M, Yin L, Zhang K, Sun W, Yang S, Zhang B, Salzman P, Wang W, Liu C, Vidyasagar S, Zhang L, Ju S, Okunieff P, Zhang L Response patterns of cytokines/chemokines in two murine strains after irradiation. Cytokine, 2012-01-25;58(2):169-77. 2012-01-25 [PMID: 22277799] (Luminex Development, Mouse)	Luminex Development	Mouse
Leslee Sprague, Maria Muccioli, Michelle Pate, Evan Meles, John McGinty, Harika Nandigam et al. The interplay between surfaces and soluble factors define the immunologic and angiogenic properties of myeloid dendritic cells BMC Immunology 12/1/2011 [PMID: 21645356]
Shchors K, Shchors E, Rostker F, Lawlor ER, Brown-Swigart L, Evan GI The Myc-dependent angiogenic switch in tumors is mediated by interleukin 1beta. Genes Dev., 2006-09-15;20(18):2527-38. 2006-09-15 [PMID: 16980582] (ELISA Development, Mouse)	ELISA Development	Mouse
Kim B, Lee S, Suvas S, Rouse BT Application of plasmid DNA encoding IL-18 diminishes development of herpetic stromal keratitis by antiangiogenic effects. J. Immunol., 2005-07-01;175(1):509-16. 2005-07-01 [PMID: 15972686] (ELISA Development, Flow Cytometry, Mouse)	ELISA Development, Flow Cytometry	Mouse

Array BAF493

• VEGF Antibodies
• VEGF ELISA Kits
• VEGF Lysates
• VEGF Proteins
• VEGF ELISAs
• VEGF Proteins and Enzymes