VEGF Antibody [Biotin] - 165

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Vascular Endothelial Growth Factor (VEGF or VEGF-A), also known as Vascular Permeability Factor (VPF), is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. It is a member of the PDGF family that is characterized by the presence of eight conserved cysteine residues and a cystine knot structure. VEGF165 appears to be the most abundant and potent isoform, followed by VEGF121 and VEGF189. Human VEGF165 is an approximately 44 kDa molecular weight homodimer sharing 88% aa sequence identity with corresponding regions of mouse and rat, 96% with porcine, 95% with canine, and 93% with feline, equine and bovine VEGF, respectively. VEGF binds the type I transmembrane receptor tyrosine kinases VEGF R1 (also called Flt-1) and VEGF R2 (Flk-1/KDR) on endothelial cells. Although VEGF affinity is highest for binding to VEGF R1, VEGF R2 appears to be the primary mediator of VEGF angiogenic activity. VEGF165 binds the Semaphorin receptor, Neuropilin-1 and promotes complex formation with VEGF R2. VEGF is required during embryogenesis and functions to regulate the proliferation, migration, and survival of endothelial cells. In adults, VEGF functions mainly in wound healing and the female reproductive cycle. Pathologically, it is involved in tumor angiogenesis and vascular leakage. Circulating VEGF levels correlate with disease activity in autoimmune diseases such as rheumatoid arthritis, multiple sclerosis and systemic lupus erythematosus. VEGF is induced by hypoxia and cytokines such as IL-1, IL-6, IL-8, Oncostatin M (OSM) and TNF-alpha.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 11 applications: Array Development, Bioassay, ELISA Detection, ELISA Development, ELISA Development (Detection), ELISA Microarray Development, Functional Assay, PLA, Quantum Dot, TaqMan Protein Assay, Western Blot.

Showing Publications 1 - 10 of 28. Show All 28 Publications. Collapse Publications.

Publications using BAF293	Applications	Species
Roaa H. Alalwany, Tom Hawtrey, Kevin Morgan, Jonathan C. Morris, Lucy F. Donaldson, David O. Bates Vascular endothelial growth factor isoforms differentially protect neurons against neurotoxic events associated with Alzheimer’s disease Frontiers in Molecular Neuroscience 6/27/2023 [PMID: 37456522]
Pedersen, T;Fojan, P;Pedersen, AKN;Magnusson, NE;Gurevich, L; Amperometric Biosensor for Quantitative Measurement Using Sandwich Immunoassays Biosensors 2023-05-05 [PMID: 37232880] (ELISA Detection, Human)	ELISA Detection	Human
J Sundblom, TP Skare, O Holm, S Welin, M Braun, P Nilsson, P Enblad, EO Sjöström, A Smits Central nervous system hemangioblastomas in von Hippel-Lindau disease: Total growth rate and risk of developing new lesions not associated with circulating VEGF levels PLoS ONE, 2022-11-28;17(11):e0278166. 2022-11-28 [PMID: 36441756] (PLA, Human)	PLA	Human
DL Zhao, HT Li, SH Liu TIMP3/TGF?&beta1 axis regulates mechanical loading?induced chondrocyte degeneration and angiogenesis Molecular Medicine Reports, 2020-07-29;0(0):. 2020-07-29 [PMID: 32945489] (Functional Assay, Human)	Functional Assay	Human
Jinhee Lee, Atsuro Tatsumi, Kaori Tsukakoshi, Ellie D. Wilson, Koichi Abe, Koji Sode et al. Application of a Glucose Dehydrogenase-Fused with Zinc Finger Protein to Label DNA Aptamers for the Electrochemical Detection of VEGF Sensors (Basel) 7/11/2020 [PMID: 32664558]
ML Carbone, PM Lacal, S Messinese, L De Giglio, C Pozzilli, S Persechino, C Mazzanti, CM Failla, G Pagnanelli Multiple Sclerosis Treatment and Melanoma Development Int J Mol Sci, 2020-04-22;21(8):. 2020-04-22 [PMID: 32331328] (ELISA Development (Detection), Human)	ELISA Development (Detection)	Human
RJ Smith, B Nasiri, J Kann, D Yergeau, JE Bard, DD Swartz, ST Andreadis Endothelialization of arterial vascular grafts by circulating monocytes Nat Commun, 2020-04-01;11(1):1622. 2020-04-01 [PMID: 32238801] (Bioassay, Human)	Bioassay	Human
K Tzelepis, E De Braekel, D Aspris, I Barbieri, MS Vijayabask, WH Liu, M Gozdecka, E Metzakopia, HD Toop, M Dudek, SC Robson, F Hermida-Pr, YH Yang, R Babaei-Jad, DA Garyfallos, H Ponstingl, JML Dias, P Gallipoli, M Seiler, S Buonamici, B Vick, AJ Bannister, R Rad, RK Prinjha, JC Marioni, B Huntly, J Batson, JC Morris, C Pina, A Bradley, I Jeremias, DO Bates, K Yusa, T Kouzarides, GS Vassiliou SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4 Nat Commun, 2018-12-19;9(1):5378. 2018-12-19 [PMID: 30568163] (Human)		Human
S Gogalic, U Sauer, S Doppler, C Preininger Investigating Colorimetric Protein Array Assay Schemes for Detection of Recurrence of Bladder Cancer Biosensors (Basel), 2018-01-24;8(1):. 2018-01-24 [PMID: 29364182] (Array Development, Human)	Array Development	Human
J Ikari, AJ Nelson, J Obaid, A Giron-Mart, K Ikari, F Makino, S Iwasawa, Y Gunji, M Farid, X Wang, H Basma, D Demeo, C Feghali-Bo, O Holz, K Rabe, X Liu, SI Rennard Reduced microRNA-503 expression augments lung fibroblast VEGF production in chronic obstructive pulmonary disease PLoS ONE, 2017-09-07;12(9):e0184039. 2017-09-07 [PMID: 28880936] (ELISA Development (Detection), Human)	ELISA Development (Detection)	Human
MG Atzori, L Tentori, F Ruffini, C Ceci, L Lisi, E Bonanno, M Scimeca, E Eskilsson, T Daubon, H Miletic, L Ricci Viti, R Pallini, P Navarra, R Bjerkvig, S D'Atri, PM Lacal, G Graziani The anti-vascular endothelial growth factor receptor-1 monoclonal antibody D16F7 inhibits invasiveness of human glioblastoma and glioblastoma stem cells J. Exp. Clin. Cancer Res., 2017-08-10;36(1):106. 2017-08-10 [PMID: 28797294] (ELISA Development (Detection), Human)	ELISA Development (Detection)	Human
McDonald G, Tabellini L, Storer B, Martin P, Lawler R, Rosinski S, Schoch H, Hansen J Predictive Value of Clinical Findings and Plasma Biomarkers after Fourteen Days of Prednisone Treatment for Acute Graft-versus-host Disease. Biol Blood Marrow Transplant, 2017-05-03;23(8):1257-1263. 2017-05-03 [PMID: 28478120] (Human)		Human
E Brencicova, AL Jagger, HG Evans, M Georgouli, A Laios, S Attard Mon, G Mehra, J Spencer, AA Ahmed, S Raju-Kanki, LS Taams, SS Diebold Interleukin-10 and prostaglandin E2 have complementary but distinct suppressive effects on Toll-like receptor-mediated dendritic cell activation in ovarian carcinoma PLoS ONE, 2017-04-14;12(4):e0175712. 2017-04-14 [PMID: 28410380] (ELISA Development (Detection), Human)	ELISA Development (Detection)	Human
Claudia Ceci Ellagic Acid Inhibits Bladder Cancer Invasiveness and In Vivo Tumor Growth Nutrients, 2016-11-22;8(11):. 2016-11-22 [PMID: 27879653] (ELISA Development (Detection), Human)	ELISA Development (Detection)	Human
Compound 49b Restores Retinal Thickness and Reduces Degenerate Capillaries in the Rat Retina following Ischemia/Reperfusion PLoS ONE, 2016-07-20;11(7):e0159532. 2016-07-20 [PMID: 27439004] (Western Blot, Human)	Western Blot	Human
James G. Carter, Melissa V. R. Gammons, Gopinath Damodaran, Amanda J. Churchill, Steven J. Harper, David O. Bates The carboxyl terminus of VEGF-A is a potential target for anti-angiogenic therapy Angiogenesis 1/1/2015 [PMID: 25274272]
Hendel , Alon, Hsu , Ivy, Granville , David J Granzyme B releases vascular endothelial growth factor from extracellular matrix and induces vascular permeability. Lab Invest, 2014-05-05;94(7):716-25. 2014-05-05 [PMID: 24791744] (Western Blot, Human)	Western Blot	Human
Ruffini F, Tentori L, Dorio A, Arcelli D, D'Amati G, D'Atri S, Graziani G, Lacal P Platelet-derived growth factor C and calpain-3 are modulators of human melanoma cell invasiveness. Oncol Rep, 2013-10-10;30(6):2887-96. 2013-10-10 [PMID: 24126726] (ELISA Development, Human)	ELISA Development	Human
Vascular endothelial growth factor signals through platelet-derived growth factor receptor beta in meningiomas in vitro. Br. J. Cancer, 2012-10-09;107(10):1702-13. 2012-10-09 [PMID: 23047550] (TaqMan Protein Assay, Human)	TaqMan Protein Assay	Human
Robin D. Hamilton, Lopa Leach Isolation and Properties of an In Vitro Human Outer Blood-Retinal Barrier Model Methods in Molecular Biology 1/1/2011 [PMID: 21082384]
Won Sik Lee, Yasuhiro Suzuki, Scott S. Graves, Mineo Iwata, G.M. Venkataraman, Marco Mielcarek et al. Canine Bone Marrow Derived Mesenchymal Stromal Cells Suppress Allo-Reactive Lymphocyte Proliferation in Vitro but Fail to Enhance Engraftment in Canine Bone Marrow Transplantation Biology of Blood and Marrow Transplantation 4/1/2011 [PMID: 20457265]
Soman C, Giorgio T Sensitive and multiplexed detection of proteomic antigens via quantum dot aggregation. Nanomedicine, 2009-02-13;5(4):402-9. 2009-02-13 [PMID: 19523417] (Quantum Dot, Human)	Quantum Dot	Human
Gonzalez RM, Seurynck-Servoss SL, Crowley SA Development and validation of sandwich ELISA microarrays with minimal assay interference. J. Proteome Res., 2008-04-19;7(6):2406-14. 2008-04-19 [PMID: 18422355] (ELISA Microarray Development, Human)	ELISA Microarray Development	Human
Todd J, Freese B, Lu A, Held D, Morey J, Livingston R, Goix P Ultrasensitive flow-based immunoassays using single-molecule counting. Clin. Chem., 2007-09-21;53(11):1990-5. 2007-09-21 [PMID: 17890441] (ELISA Development, Human)	ELISA Development	Human
Chen DS, Soen Y, Stuge TB Marked differences in human melanoma antigen-specific T cell responsiveness after vaccination using a functional microarray. PLoS Med., 2005-09-20;2(10):e265. 2005-09-20 [PMID: 16162034] (Functional Assay, Human)	Functional Assay	Human
Heung-Sun Kwon, Hyun-Chul Shin, Jin-Soo Kim Suppression of vascular endothelial growth factor expression at the transcriptional and post-transcriptional levels Nucleic Acids Research 4/28/2005 [PMID: 15860771]
Caine GJ, Blann AD, Stonelake PS, Ryan P, Lip GY Plasma angiopoietin-1, angiopoietin-2 and Tie-2 in breast and prostate cancer: a comparison with VEGF and Flt-1. Eur. J. Clin. Invest., 2003-10-01;33(10):883-90. 2003-10-01 [PMID: 14511360] (ELISA Development, Human)	ELISA Development	Human
Keane MP, Donnelly SC, Belperio JA, Goodman RB, Dy M, Burdick MD, Fishbein MC, Strieter RM Imbalance in the expression of CXC chemokines correlates with bronchoalveolar lavage fluid angiogenic activity and procollagen levels in acute respiratory distress syndrome. J. Immunol., 2002-12-01;169(11):6515-21. 2002-12-01 [PMID: 12444162] (ELISA Development, Human)	ELISA Development	Human
Show All 28 Publications. Collapse Publications.

Array BAF293

• VEGF Antibodies
• VEGF ELISA Kits
• VEGF Lysates
• VEGF Proteins
• VEGF Proteins and Enzymes
• VEGF ELISAs