TRAF-4 Antibody

The TRAF (TNF receptor-associated factor) family is a group of adapter proteins (TRAFs 1-6) that link a wide variety of cell surface receptors to diverse signaling cascades leading to the activation of NF-kB and mitogen-activated protein kinases (reviewed in Chung et al, 2002). TRAFs are major signal transducers for both the TNF and IL- 1/TLR receptor superfamilies and collectively play important functions in both adaptive and innate immunity. The carboxy-terminal region of TRAFs is required for self-association and interaction with receptor cytoplasmic domains following ligand-induced oligomerization. TRAFs interact with a variety of proteins that regulate receptor-induced cell death or survival, and TRAF-mediated signaling can promote cell survival or interfere with death receptor-induced apoptosis.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 application: IP.

Showing Publication 1 - 1 of 1.

Publication using NB100-56177	Applications	Species
Krajewska M, Krajewski S, Zapata JM et al. TRAF-4 expression in epithelial progenitor cells. Analysis in normal adult, fetal, and tumor tissues. Am J Pathol. 1998-06-01 [PMID: 9626059] (IP) Details: 1. IP (Fig 2): The TRAF4 antibody specifically immunoprecipitated in vitro translated human TRAF4, but did not precipitated in vitro translated TRAFs 2, 3, 5, or 6. This validated the specificity of the TRAF4 antibody.	IP

Array NB100-56177

• TRAF-4 Antibodies
• TRAF-4 Lysate
• TRAF-4 Proteins