TRAF-4 Products

Description

The TRAF (TNF receptor-associated factor) family is a group of adapter proteins (TRAFs 1-6) that link a wide variety of cell surface receptors to diverse signaling cascades leading to the activation of NF-kB and mitogen-activated protein kinases (reviewed in Chung et al, 2002). TRAFs are major signal transducers for both the TNF and IL- 1/TLR receptor superfamilies and collectively play important functions in both adaptive and innate immunity. The carboxy-terminal region of TRAFs is required for self-association and interaction with receptor cytoplasmic domains following ligand-induced oligomerization. TRAFs interact with a variety of proteins that regulate receptor-induced cell death or survival, and TRAF-mediated signaling can promote cell survival or interfere with death receptor-induced apoptosis.

Bioinformatics

Entrez	9618 Human
Uniprot	AAH01769 Human NM_004295 Human NP_004286 Human NP_004286.2 Human Q9BUZ4 Human
Product By Gene ID	9618
Alternate Names	CART1RING finger protein 83 Cysteine-rich domain associated with RING and Traf domains protein 1 Metastatic lymph node gene 62 protein MLN 62 MLN62cysteine-rich domain associated with ring and TRAF domain RNF83malignant 62 TNF receptor-associated factor 4 tumor necrosis receptor-associated factor 4A

Research Areas for TRAF-4

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Cancer
Zinc Finger