Synapsin I Antibody

Synapsin I, also called Synapsin-1 or SYN1, belongs to Synapsin family (Synapsin I, Synapsin II, Synapsin III) of evolutionarily conserved phospho-proteins which are associated with the cytosolic side of the synaptic vesicles and tether the latter to actin cytoskeleton, thus forming a reserve pool. Synapsins represents the most abundant of neuron-specific phosphor-proteins, consisting 9% of the total amount of all vesicle proteins in neurons wherein they play a critical role in the regulation of neurotransmitter release. Synapsin I is present in axon terminals and plays a role in regulating the secretion of neurotransmitters; thus, it influences synaptic plasticity by regulating pre- and post-synaptic vesicular release. Synapsins I and II are typically found in mature synapses, while synapsin III is often attributed to developing synapses with lesser overall expression. Phosphorylation at Ser-9 residue results in dissociation of Synapsins I from synaptic vesicles which is important for synaptic vesicle neurotransmitter release. Mutations in Synapsin I have been linked to Epilepsy X-linked, with variable learning disabilities and behavior disorders (XELBD) which is a neurologic disorder characterized by variable combinations of epilepsy, learning difficulties, macrocephaly, and aggressive behavior.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 5 confirmed species: Human, Mouse, Rat, Guinea Pig, Primate.

We have publications tested in 8 applications: ICC/IF, IF/IHC, IHC, IHC-Fr, IHC-FrFl, IHC-P, IP, WB.

Showing Publications 1 - 10 of 52. Show All 52 Publications. Collapse Publications.

Publications using NB300-104	Applications	Species
Karliner J, Merry DE Differentiating PC12 cells to evaluate neurite densities through live-cell imaging STAR protocols 2023-01-04 [PMID: 36602900] (WB, ICC/IF, Rat) Details: Dilution used in WB and ICC/IF 1:1000	WB, ICC/IF	Rat
Bueno C, Martinez-Morga M, Martinez S. Nuclear polymorphism and non-proliferative adult neurogenesis in human neural crest-derived cells. bioRxiv 2018-05-18
Štepánková K, Chudí?ková M, Šimková Z et al. Oral administration of 4-methylumbelliferone reduces glial scar and promotes anatomical plasticity bioRxiv 2023-02-04 (IHC-FrFl, Rat)	IHC-FrFl	Rat
Štepánková K, Chudí?ková M, Šimková Z et al. Low oral dose of 4-methylumbelliferone reduces glial scar but is insufficient to induce functional recovery after spinal cord injury Scientific reports 2023-11-06 [PMID: 37932336] (IHC, Rat)	IHC	Rat
Tang C, Liu M, Zhou Z et al. Treadmill Exercise Alleviates Cognition Disorder by Activating the FNDC5: Dual Role of Integrin ?V/?5 in Parkinson’s Disease International Journal of Molecular Sciences 2023-04-25 [PMID: 37175535] (WB, Mouse)	WB	Mouse
Ma KG, Hu HB, Zhou JS Et al. Neuronal Glypican4 promotes mossy fiber sprouting through the mTOR pathway after pilocarpine-induced status epilepticus in mice Experimental neurology 2021-11-05 [PMID: 34748756] (WB, IF/IHC, Mouse)	WB, IF/IHC	Mouse
Rizzo FR, Guadalupi L, Sanna K Et al. Exercise protects from hippocampal inflammation and neurodegeneration in experimental autoimmune encephalomyelitis Brain, behavior, and immunity 2021-08-12 [PMID: 34391817] (WB, Mouse)	WB	Mouse
Yang Y, Zhang J, Yang X et al. Dysregulated APP expression and alpha-secretase processing of APP is involved in manganese-induced cognitive impairment Ecotoxicology and environmental safety 2021-05-28 [PMID: 34058678] (ICC/IF, WB, Mouse)	ICC/IF, WB	Mouse
Lamotte J, Roqueviere S, Gautier H, et al. hiPSC-Derived Neurons Provide a Robust and Physiologically Relevant In Vitro Platform to Test Botulinum Neurotoxins Frontiers in Pharmacology 2021-01-14 [PMID: 33519485] (ICC/IF, Human)	ICC/IF	Human
Lin L, Petralia RS, Lake R et al. A novel structure associated with aging is augmented in the DPP6-KO mouse brain Acta Neuropathol Commun 2020-11-23 [PMID: 33225987] (IF/IHC, Mouse) Details: DPP6-KO and wild type mice hippocampi were analyzed via immunohistochemistry	IF/IHC	Mouse
Petrova N, Nutma E, Carassiti D et al. Synaptic Loss in Multiple Sclerosis Spinal Cord Ann. Neurol. 2020-06-30 [PMID: 32608018] (IF/IHC, Human)	IF/IHC	Human
Bueno C, Martinez-Morga M, Martinez S. Non-proliferative adult neurogenesis in neural crest-derived stem cells isolated from human periodontal ligament. bioRxiv 2018-05-18 [PMID: 31792338] (ICC/IF, Human)	ICC/IF	Human
Bueno C, Martinez-Morga M, et al. Non-proliferative neurogenesis in human periodontal ligament stem cells. Sci Rep 2019-12-02 [PMID: 31792338] (ICC/IF, Human)	ICC/IF	Human
Maslon, MM;Braunschweig, U;Aitken, S;Mann, AR;Kilanowski, F;Hunter, CJ;Blencowe, BJ;Kornblihtt, AR;Adams, IR;Caceres, JF; A slow transcription rate causes embryonic lethality and perturbs kinetic coupling of neuronal genes EMBO J. 2019-05-02 [PMID: 30988016] (ICC/IF, Mouse)	ICC/IF	Mouse
Vishwakarma S. K, Bardia A, et al. Bioengineering Human Neurological Constructs Using Decellularized Meningeal Scaffolds for Application in Spinal Cord Injury. Front Bioeng Biotechnol 2018-11-18 [PMID: 30443545] (WB, IF/IHC, Human)	WB, IF/IHC	Human
Lai HM, Liu AKL, Ng HHM et al. Next generation histology methods for three-dimensional imaging of fresh and archival human brain tissues. Nat Commun. 2018-03-14 [PMID: 29540691] (IF/IHC, Human)	IF/IHC	Human
Lam CS, Tipoe GL, Wong JK et al. M30 Antagonizes Indoleamine 2,3-Dioxygenase Activation and Neurodegeneration Induced by Corticosterone in the Hippocampus. PLoS ONE. 2016-11-21 [PMID: 27870896] (WB, Rat)	WB	Rat
Cesca F, Limongi T, Accardo A. Fabrication of biocompatible free-standing nanopatterned films for primary neuronal cultures. RSC Adv. 2014-01-01 (ICC/IF, Mouse)	ICC/IF	Mouse
Scofield MD, Li H, Siemsen BM et al. Cocaine Self-Administration and Extinction Leads to Reduced Glial Fibrillary Acidic Protein Expression and Morphometric Features of Astrocytes in the Nucleus Accumbens Core. Biol Psychiatry. 2015-12-31 [PMID: 26946381] (IHC-Fr, Rat)	IHC-Fr	Rat
Liu C, Song X, Nisbet R, Gotz J. Co-immunoprecipitation with tau isoform-specific antibodies reveals distinct protein interactions, and highlights a putative role for 2N tau in disease. J Biol Chem. 2016-02-09 [PMID: 26861879] (IP, Mouse)	IP	Mouse
Gho CG, Schomann T, de Groot SC et al. Isolation, expansion and neural differentiation of stem cells from human plucked hair: a further step towards autologous nerve recovery. Cytotechnology. 2015-12-24 [PMID: 26702932] (WB, Human)	WB	Human
Tang LT, Craig TJ, Henley JM. SUMOylation of synapsin Ia maintains synaptic vesicle availability and is reduced in an autism mutation. Nat Commun. 2015-07-15 [PMID: 26173895] (WB, ICC/IF, Mouse, Rat)	WB, ICC/IF	Mouse, Rat
Graser S, Mentrup B, Schneider D et al. Overexpression of tissue-nonspecific alkaline phosphatase increases the expression of neurogenic differentiation markers in the human SH-SY5Y neuroblastoma cell line. Bone. 2015-10-01 [PMID: 26032516] (ICC/IF, Human)	ICC/IF	Human
Koga K, Liu M G et al. Impaired presynaptic long-term potentiation in the anterior cingulate cortex of Fmr1 knock-out mice. J Neurosci 2015-04-02 [PMID: 25653361] (WB, Mouse)	WB	Mouse
Mellott JG, Bickford ME, Schofield BR. Descending projections from auditory cortex to excitatory and inhibitory cells in the nucleus of the brachium of the inferior colliculus. Front Syst Neurosci. 2014-10-06 [PMID: 25339870] (WB, IHC-FrFl, Guinea Pig)	WB, IHC-FrFl	Guinea Pig
Ho VM, Dallalzadeh LO, Karathanasis N et al. GluA2 mRNA distribution and regulation by miR-124 in hippocampal neurons. Mol Cell Neurosci. 2014-07-01 [PMID: 24784359] (ICC/IF, Mouse)	ICC/IF	Mouse
Hu Q, Liang X, Chen D et al. Delayed hyperbaric oxygen therapy promotes neurogenesis through reactive oxygen species/hypoxia-inducible factor-1alpha/beta-catenin pathway in middle cerebral artery occlusion rats. Stroke. 2014-06-01 [PMID: 24757104] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Paemka L, Mahajan VB, Skeie JM et al. PRICKLE1 interaction with SYNAPSIN I reveals a role in autism spectrum disorders. PLoS One. 2013-12-03 [PMID: 24312498] (ICC/IF, WB, IP, Mouse)	ICC/IF, WB, IP	Mouse
Federici M, Latagliata EC, Ledonne A et al. Paradoxical abatement of striatal dopaminergic transmission by cocaine and methylphenidate. J. Biol. Chem. 2014-01-03 [PMID: 24280216] (WB, Mouse)	WB	Mouse
Efthymiou A, Shaltouki A, Steiner JP et al. Functional screening assays with neurons generated from pluripotent stem cell-derived neural stem cells. J Biomol Screen. 2014-01-01 [PMID: 24019252] (ICC/IF, Human)	ICC/IF	Human
Mori F, Nistico R, Mandolesi G et al. Interleukin-1beta Promotes Long-Term Potentiation in Patients with Multiple Sclerosis. Neuromolecular Med 2013-07-28 [PMID: 23892937] (WB, Mouse)	WB	Mouse
Puglisi F, Vanni V, Ponterio G et al. Torsin A Localization in the Mouse Cerebellar Synaptic Circuitry. PLoS One 2013-06-19 [PMID: 23840813] (WB, Mouse)	WB	Mouse
Paonessa F, Latifi S, Scarongella H et al. Specificity protein 1 (Sp1)-dependent activation of the synapsin I gene (SYN1) is modulated by RE1-silencing transcription factor (REST) and 5'-cytosine-phosphoguanine (CpG) methylation. J Biol Chem. 2013-02-01 [PMID: 23250796] (WB, ICC/IF, Mouse, Human)	WB, ICC/IF	Mouse, Human
Limongi T, Cesca F, Gentile F et al. Nanostructured superhydrophobic substrates trigger the development of 3D neuronal networks. Small. 2013-02-11 [PMID: 23027505] (ICC/IF, Mouse)	ICC/IF	Mouse
Ramos C, Chardonnet S, Marchand CH et al. Native presynaptic metabotropic glutamate receptor 4 (mGluR4) interacts with exocytosis proteins in rat cerebellum. J Biol Chem. 2012-06-08 [PMID: 22528491] (WB, Rat)	WB	Rat
Trushina E, Nemutlu E, Zhang S et al. Defects in mitochondrial dynamics and metabolomic signatures of evolving energetic stress in mouse models of familial Alzheimer's disease. PLoS One. 2012-01-01 [PMID: 22393443] (ICC/IF, Mouse)	ICC/IF	Mouse
Cronin T, Lyubarsky A, Bennett J. Dark-rearing the rd10 mouse: implications for therapy. Adv Exp Med Biol. 2012-01-01 [PMID: 22183325] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Ren WW, Liu Y, Li BM. Stimulation of alpha(2A)-adrenoceptors promotes the maturation of dendritic spines in cultured neurons of the medial prefrontal cortex. Mol Cell Neurosci. 2012-02-01 [PMID: 22015717] (ICC/IF, WB, Mouse)	ICC/IF, WB	Mouse
Lasagna-Reeves CA, Castillo-Carranza DL, Sengupta U et al. Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice. Mol Neurodegener. 2011-06-06 [PMID: 21645391] (WB, Mouse)	WB	Mouse
VanGuilder HD, Farley JA, Yan H et al. Hippocampal dysregulation of synaptic plasticity-associated proteins with age-related cognitive decline. Neurobiol Dis. 2011-07-01 [PMID: 21440628] (WB, Rat)	WB	Rat
Steinman MQ, Crean KK, Trainor BC. Photoperiod interacts with food restriction in performance in the Barnes maze in female California mice. Eur J Neurosci. 2011-01-01 [PMID: 21198981] (IHC-FrFl, WB, Mouse)	IHC-FrFl, WB	Mouse
Hsieh CY, Nakamura PA, Luk SO et al. Ephrin-B reverse signaling is required for formation of strictly contralateral auditory brainstem pathways. J Neurosci. 2010-07-21 [PMID: 20660266] (IHC-FrFl, Mouse)	IHC-FrFl	Mouse
Sherwood CC, Duka T, Stimpson CD et al. Neocortical synaptophysin asymmetry and behavioral lateralization in chimpanzees (Pan troglodytes). Eur J Neurosci. 2010-04-01 [PMID: 20384782] (WB, Primate)	WB	Primate
Gelman BB, Nguyen TP Synaptic proteins linked to HIV-1 infection and immunoproteasome induction: proteomic analysis of human synaptosomes. J Neuroimmune Pharmacol. 2010-03-01 [PMID: 19693676] (WB, Human)	WB	Human
Kim SS, Yoo SW, Park TS et al. Neural induction with neurogenin1 increases the therapeutic effects of mesenchymal stem cells in the ischemic brain. Stem Cells. 2008-09-01 [PMID: 18617687] (IHC-P, Rat)	IHC-P	Rat
Kennedy, N et al. Requirements of JIP scaffold proteins for NMDA-mediated signal transduction. Genes Development; 21: 2336-2346. 2007-01-01 [PMID: 17875667] (ICC/IF, Mouse)	ICC/IF	Mouse
Thalhammer A, Rudhard Y, Tigaret CM et al. CaMKII translocation requires local NMDA receptor-mediated Ca2+ signaling. EMBO J. 2006-12-13 [PMID: 17124502] (ICC/IF, Mouse)	ICC/IF	Mouse
Hanus, C, Ehrensperger, M-V, Triller, A. Activity-Dependent Movements of Postsynaptic Scaffolds at Inhibitory Synapses. 26, 4586-4595. 2006-01-01 [PMID: 16641238] (ICC/IF, Rat)	ICC/IF	Rat
Rastaldi MP, Armelloni S, Berra S et al. Glomerular podocytes contain neuron-like functional synaptic vesicles. FASEB J. 2006-05-01 [PMID: 16585060] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Specht CG, Tigaret CM, Rast GF et al. Subcellular localisation of recombinant alpha- and gamma-synuclein. Mol Cell Neurosci. 2005-02-01 [PMID: 15691713] (ICC/IF, Mouse)	ICC/IF	Mouse
Danglot, L et al. Association of gephyrin with synaptic extrasynaptic GABAA receptors varies during development in cultured hippocampal neurons. Molecular Cellular Neuroscience; 23:264-278. 2003-01-01 [PMID: 12812758]
Stone LM, Browning MD, Finger TE. Differential distribution of the synapsins in the rat olfactory bulb. J Neurosci. 1994-01-01 [PMID: 8283238] (IHC-Fr, WB, Rat) Details: WB (rat cortex), Fig 2; IHC (cryosections) on rat olfacotry bulb, Figs 5 and 6.	IHC-Fr, WB	Rat
Show All 52 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Verified Customer	IHC-P	Human	04/17/2018	View Summary Application Immunohistochemistry-Paraffin Sample Tested Brain (cerebellum) tissue Species Human Lot ajo516g Comments Comments Citrate antigen retrieval, pH6 1 in 250 dilution

Array NB300-104

• Synapsin I Antibodies
• Synapsin I Lysate
• Synapsin I Protein