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SOX10 Antibody [Unconjugated]

Name: SOX10 Antibody [Unconjugated]
Brand: Novus Biologicals
SKU: AF2864
Rating: 5 (2 reviews)

(113 Publications)

(2 Reviews)

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SOX10 was detected in immersion fixed SK‑Mel‑28 human malignant melanoma cell line using Goat Anti-Human SOX10 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2864) at 15 µg/mL for 3 ...read more

SOX10 was detected in immersion fixed BG01V human embryonic stem cells differentiated to neural crest stem cells using Goat Anti-Human SOX10 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2864) at 10 µg/mL ...read more

SOX10 was detected in immersion fixed paraffin-embedded sections of human melanoma tissue using Goat Anti-Human SOX10 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2864) at 15 µg/mL for 1 hour at ...read more

PDGFR alpha driven brain tumors display features of high grade glioma.(a–g) Histopathological analysis of tumor areas by H&E staining shows a high concentration of mitotic figures (a, arrows), high cellularity and ...read more

Adult dynamin 2-depleted Schwann cells are replaced by dynamin 2-positive Schwann cells in remyelinated nerves.(A) Immunostainings for DNM2, SOX10 (SCs) and YFP (reporter-recombined SCs) on SN cross-sections of control* ...read more

Schwann cells lacking dynamin 2 show impaired cell cycle progression, reduced mitosis rate, and cytokinesis defects.(A) Schematic representation of the cell cycle phases marked by Ki-67 and EdU. (B) EdU-labeling, ...read more

Product Details

Summary

Reactivity	HuSpecies Glossary
Applications	WB, IHC, ICC/IF
Clonality	Polyclonal
Host	Goat
Conjugate	Unconjugated
Concentration	LYOPH

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Biotin BAF2864

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Carrier Free AF2864-SP

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Conjugate	Catalog #	Availability	Size	Price
Biotin	BAF2864

SOX10 Antibody [Unconjugated] Summary

Immunogen	E. coli-derived recombinant human SOX10 Met1-Ala118 Accession # P56693
Specificity	Detects human SOX10 in direct ELISAs and Western blots.
Source	N/A
Isotype	IgG
Clonality	Polyclonal
Host	Goat
Gene	SOX10
Purity Statement	Antigen Affinity-purified
Innovator's Reward	Test in a species/application not listed above to receive a full credit towards a future purchase. Learn about the Innovator's Reward

Applications/Dilutions

Dilutions

Immunocytochemistry 5-15 ug/mL
Immunohistochemistry 5-15 ug/mL
Western Blot 0.1 ug/mL

Reviewed Applications

Read 2 Reviews rated 5

using
AF2864 in the following applications:

Immunohistochemistry-Frozen
Immunohistochemistry-Paraffin

Publications

Read Publications using
AF2864 in the following applications:

FACS
1 publication
ICC
17 publications
ICC/IF
1 publication
IHC
24 publications
IHC-F
1 publication
IHC-Fr
4 publications
IHC-P
2 publications
IHC/IF
1 publication
Immunoprecipitation
1 publication
Proximity Ligation Assay (PLA)
1 publication
Western Blot
3 publications

Packaging, Storage & Formulations

Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer	Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative	No Preservative
Concentration	LYOPH
Reconstitution Instructions	Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for SOX10 Antibody [Unconjugated]

DOM
MGC15649
PCWH
SOX10
SRY (sex determining region Y)-box 10
SRY-related HMG-box gene 10
transcription factor SOX-10
WS4
WS4C
WS4mouse, human homolog of

Background

SOX10 belongs to the SOX family of transcription factors with diverse roles during development. In the central nervous system (CNS), SOX10 is required for the terminal differentiation of oligodendrocytes and myelination. In the peripheral nervous system, SOX10 maintains pluripotency of neural crest stem cells and suppresses neuronal differentiation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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SOX10 Antibody
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AF2864

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Publications for SOX10 Antibody (AF2864)(113)

We have publications tested in 5 confirmed species: Human, Mouse, Rat, Chicken, Transgenic Mouse.

We have publications tested in 11 applications: FACS, ICC, ICC/IF, IHC, IHC-F, IHC-Fr, IHC-P, IHC/IF, Immunoprecipitation, Proximity Ligation Assay (PLA), Western Blot.

Showing Publications 1 - 10 of 113. Show All 113 Publications.

Publications using AF2864	Applications	Species
Robinson, BG;Oster, BA;Robertson, K;Kaltschmidt, JA; Loss of ASD-related molecule Cntnap2 affects colonic motility in mice Frontiers in neuroscience 2023-11-09 [PMID: 38027494] (IHC, Transgenic Mouse)	IHC	Transgenic Mouse
Guo, R;Han, D;Song, X;Gao, Y;Li, Z;Li, X;Yang, Z;Xu, Z; Context-dependent regulation of Notch signaling in glial development and tumorigenesis Science advances 2023-11-10 [PMID: 37948517] (IHC, Mouse)	IHC	Mouse
Li J, Jaiswal MK, Chien JF et al. Divergent single cell transcriptome and epigenome alterations in ALS and FTD patients with C9orf72 mutation Nat Commun 2023-09-15 [PMID: 37714849]
Frazel, PW;Labib, D;Fisher, T;Brosh, R;Pirianian, N;Marchildon, A;Boeke, JD;Fossati, V;Liddelow, SA; Longitudinal scRNA-seq analysis in mouse and human informs optimization of rapid mouse astrocyte differentiation protocols Nature neuroscience 2023-09-11 [PMID: 37697111] (ICC, Human)	ICC	Human
Clayton, BLL;Barbar, L;Sapar, M;Rusielewicz, T;Kalpana, K;Migliori, B;NYSCF Global Stem Cell Array® Team, ;Paull, D;Brenner, K;Moroziewicz, D;Sand, IK;Casaccia, P;Tesar, PJ;Fossati, V; Patient iPSC models reveal glia-intrinsic phenotypes in multiple sclerosis bioRxiv : the preprint server for biology 2023-08-02 [PMID: 37577713] (ICC, Human)	ICC	Human
Zhenqing Liu, Jianfei Chao, Cheng Wang, Guihua Sun, Daniel Roeth, Wei Liu et al. Astrocytic response mediated by the CLU risk allele inhibits OPC proliferation and myelination in a human iPSC model Cell Reports 2023-08-29 [PMID: 37494190]
Werner, L;Gliem, M;Rychlik, N;Pavic, G;Reiche, L;Kirchhoff, F;Silva Oliveira Junior, M;Gruchot, J;Meuth, SG;Küry, P;Göttle, P; A Novel Ex Vivo Model to Study Therapeutic Treatments for Myelin Repair following Ischemic Damage International journal of molecular sciences 2023-06-30 [PMID: 37446147] (IHC, Rat)	IHC	Rat
Scavuzzo MA, Letai KC, Maeno-Hikichi Y et al. Enteric glial hub cells coordinate intestinal motility bioRxiv : the preprint server for biology 2023-06-09 [PMID: 37333182]
Seixas, AI;Morais, MRG;Brakebusch, C;Relvas, JB; A RhoA-mediated biomechanical response in Schwann cells modulates peripheral nerve myelination Progress in neurobiology 2023-06-12 [PMID: 37315917] (Western Blot, Mouse)	Western Blot	Mouse
Huang, Z;Lin, J;Jiang, H;Lin, W;Huang, Z;Chen, J;Xiao, W;Lin, Q;Wang, J;Wen, S;Zhu, Q;Liu, J; Metformin promotes Schwann cell remyelination, preserves neural tissue and improves functional recovery after spinal cord injury Neuropeptides 2023-05-19 [PMID: 37236132] (IHC, Mouse)	IHC	Mouse
BG Robinson, BA Oster, K Robertson, JA Kaltschmid Loss of ASD-Related Molecule Caspr2 Affects Colonic Motility in Mice bioRxiv : the preprint server for biology, 2023-04-19;0(0):. 4/19/2023 [PMID: 37131706]
SV Fazal, C Mutschler, CZ Chen, M Turmaine, CY Chen, YP Hsueh, A Ibañez-Gra, A Loreto, A Casillas-B, H Cabedo, RJM Franklin, RA Barker, KR Monk, BJ Steventon, MP Coleman, JA Gomez-Sanc, P Arthur-Far SARM1 detection in myelinating glia: sarm1/Sarm1 is dispensable for PNS and CNS myelination in zebrafish and mice Frontiers in Cellular Neuroscience, 2023-04-05;17(0):1158388. 2023-04-05 [PMID: 37091921] (ICC, Mouse)	ICC	Mouse
Anna F. Rockel, Nicole Wagner, Peter Spenger, Süleyman Ergün, Philipp Wörsdörfer Neuro-mesodermal assembloids recapitulate aspects of peripheral nervous system development in vitro Stem Cell Reports 2023-05-09 [PMID: 37084722]
Yao Lulu Xing, Jasmine Poh, Bernard H.A. Chuang, Kaveh Moradi, Stanislaw Mitew, William D. Richardson et al. High-efficiency pharmacogenetic ablation of oligodendrocyte progenitor cells in the adult mouse CNS Cell Reports Methods 2023-02-27 [PMID: 36936074]
Y Chen, C Wu, S Peng, D Guo, H Ouyang, Y Wei, R Ju, X Ding, Z Xie, C Liu Single-Cell Characterization of the Frizzled 5 (Fz5) Mutant Mouse and Human Persistent Fetal Vasculature (PFV) Investigative Ophthalmology & Visual Science, 2023-03-01;64(3):8. 2023-03-01 [PMID: 36867129] (IHC, Mouse)	IHC	Mouse
Weifeng Li, Cynthia Berlinicke, Yinyin Huang, Stefanie Giera, Anna G. McGrath, Weixiang Fang et al. High-throughput screening for myelination promoting compounds using human stem cell-derived oligodendrocyte progenitor cells iScience 3/17/2023 [PMID: 36852281]
EF Cohn, BLL Clayton, M Madhavan, S Yacoub, Y Federov, K Paul-Fried, TJ Shafer, PJ Tesar Pervasive environmental chemicals impair oligodendrocyte development bioRxiv : the preprint server for biology, 2023-02-12;0(0):. 2023-02-12 [PMID: 36798415] (IHC, Human)	IHC	Human
S Buller, S Kohnke, R Hansford, T Shimizu, WD Richardson, C Blouet Median eminence myelin continuously turns over in adult mice Molecular Metabolism, 2023-02-04;69(0):101690. 2/4/2023 [PMID: 36739968]
Z Li, K Chen, Q Shao, H Lu, X Zhang, Y Pu, X Sun, H He, L Cao Nanoparticulate MgH2 ameliorates anxiety/depression-like behaviors in a mouse model of multiple sclerosis by regulating microglial polarization and oxidative stress Journal of Neuroinflammation, 2023-01-30;20(1):16. 2023-01-30 [PMID: 36710351] (ICC, IHC, Mouse)	ICC, IHC	Mouse
Peter Göttle, Janos Groh, Laura Reiche, Joel Gruchot, Nicole Rychlik, Luisa Werner et al. Teriflunomide as a therapeutic means for myelin repair Journal of Neuroinflammation 2023-01-07 [PMID: 36611185]
Marion J. F. Levy, Beatriz Garcia-Diaz, Frédéric Sedel, Anne Baron-Van Evercooren, Sabah Mozafari High Dose Pharmaceutical Grade Biotin (MD1003) Accelerates Differentiation of Murine and Grafted Human Oligodendrocyte Progenitor Cells In Vivo International Journal of Molecular Sciences 2022-12-12 [PMID: 36555377]
C Galante, N Marichal, FF Scarante, LM Ghayad, Y Shi, C Schuurmans, B Berninger, S Péron Enhanced proliferation of oligodendrocyte progenitor cells following retrovirus mediated Achaete-scute complex-like 1 overexpression in the postnatal cerebral cortex in vivo Frontiers in Neuroscience, 2022-12-02;16(0):919462. 2022-12-02 [PMID: 36532282] (IHC, Mouse)	IHC	Mouse
Zhao XF, Huffman LD, Hafner H et al. The injured sciatic nerve atlas (iSNAT), insights into the cellular and molecular basis of neural tissue degeneration and regeneration eLife 2022-12-14 [PMID: 36515985]
Waseem K. Raja, Esther Neves, Christopher Burke, Xin Jiang, Ping Xu, Kenneth J. Rhodes et al. Patient-derived three-dimensional cortical neurospheres to model Parkinson’s disease PLOS ONE 2022-12-01 [PMID: 36454869]
Ideno H, Imaizumi K, Shimada H, Sanosaka T, Nemoto A, Kohyama J, Okano H Human PSCs determine the competency of cerebral organoid differentiation via FGF signaling and epigenetic mechanisms. iScience, 2022-09-16;25(10):105140. 2022-09-16 [PMID: 36185382] (IHC, Human)	IHC	Human
P Karras, I Bordeu, J Pozniak, A Nowosad, C Pazzi, N Van Raemdo, E Landeloos, Y Van Herck, D Pedri, G Bervoets, S Makhzami, JH Khoo, B Pavie, J Lamote, O Marin-Beja, M Dewaele, H Liang, X Zhang, Y Hua, J Wouters, R Browaeys, G Bergers, Y Saeys, F Bosisio, J van den Oo, D Lambrechts, AK Rustgi, O Bechter, C Blanpain, BD Simons, F Rambow, JC Marine A cellular hierarchy in melanoma uncouples growth and metastasis Nature, 2022-09-21;0(0):. 2022-09-21 [PMID: 36131018] (IHC/IF, Human)	IHC/IF	Human
Aurelia A Mapps, Erica Boehm, Corinne Beier, William T Keenan, Jennifer Langel, Michael Liu et al. Satellite glia modulate sympathetic neuron survival, activity, and autonomic function eLife 2022-08-23 [PMID: 35997251]
Maria Eleni Kastriti, Louis Faure, Dorothea Von Ahsen, Thibault Gerald Bouderlique, Johan Boström, Tatiana Solovieva et al. Schwann cell precursors represent a neural crest‐like state with biased multipotency The EMBO Journal 2022-09-01 [PMID: 35815410]
X Hu, N Agarwal, MD Zhang, P Ernfors, R Kuner, JR Nyengaard, P Karlsson Identification and quantification of nociceptive Schwann cells in mice with and without Streptozotocin-induced diabetes Journal of chemical neuroanatomy, 2022-06-06;0(0):102118. 2022-06-06 [PMID: 35680105] (IHC, Mouse)	IHC	Mouse
P Kameneva, VI Melnikova, ME Kastriti, A Kurtova, E Kryukov, A Murtazina, L Faure, I Poverennay, AV Artemov, TS Kalinina, NV Kudryashov, M Bader, J Skoda, P Chlapek, L Curylova, L Sourada, J Neradil, M Tesarova, M Pasqualett, P Gaspar, VD Yakushov, BI Sheftel, T Zikmund, J Kaiser, K Fried, N Alenina, EE Voronezhsk, I Adameyko Serotonin limits generation of chromaffin cells during adrenal organ development Nature Communications, 2022-05-25;13(1):2901. 2022-05-25 [PMID: 35614045] (IHC, Rat)	IHC	Rat
FM Piccolo, NR Kastan, T Haremaki, Q Tian, TL Laundos, R De Santis, AJ Beaudoin, TS Carroll, JD Luo, K Gnedeva, F Etoc, AJ Hudspeth, AH Brivanlou Role of YAP in early ectodermal specification and a Huntington's Disease model of human neurulation Elife, 2022-04-22;11(0):. 2022-04-22 [PMID: 35451959] (ICC/IF, Human)	ICC/IF	Human
Luipa Khandker, Marisa A. Jeffries, Yun-Juan Chang, Marie L. Mather, Angelina V. Evangelou, Jennifer N. Bourne et al. Cholesterol biosynthesis defines oligodendrocyte precursor heterogeneity between brain and spinal cord Cell Reports 2022-03-01 [PMID: 35235799]
Alwyn Dady, Lindsay Davidson, Pamela A Halley, Kate G Storey Human spinal cord in vitro differentiation pace is initially maintained in heterologous embryonic environments eLife 2022-02-21 [PMID: 35188104]
Sergio Velasco-Aviles, Nikiben Patel, Angeles Casillas-Bajo, Laura Frutos-Rincón, Enrique Velasco, Juana Gallar et al. A genetic compensatory mechanism regulated by Jun and Mef2d modulates the expression of distinct class IIa Hdacs to ensure peripheral nerve myelination and repair eLife 2022-01-25 [PMID: 35076395]
Justine D. Manos, Christina N. Preiss, Nandini Venkat, Joseph Tamm, Peter Reinhardt, Taekyung Kwon et al. Uncovering specificity of endogenous TAU aggregation in a human iPSC-neuron TAU seeding model iScience 2022-01-21 [PMID: 35072001]
KG Zyner, A Simeone, SM Flynn, C Doyle, G Marsico, S Adhikari, G Portella, D Tannahill, S Balasubram G-quadruplex DNA structures in human stem cells and differentiation Nature Communications, 2022-01-10;13(1):142. 2022-01-10 [PMID: 35013231] (ICC, Human)	ICC	Human
Kelly F. Paton, Katharina Robichon, Nikki Templeton, Lisa Denny, Afnan Al Abadey, Dan Luo et al. The Salvinorin Analogue, Ethoxymethyl Ether Salvinorin B, Promotes Remyelination in Preclinical Models of Multiple Sclerosis Frontiers in Neurology 2021-12-20 [PMID: 34987466]
Li R, Walsh P, Truong V et al. Differentiation of Human iPS Cells Into Sensory Neurons Exhibits Developmental Stage-Specific Cryopreservation Challenges Frontiers in Cell and Developmental Biology 2021-12-14 [PMID: 34970550]
Fan Wang, Xiao-Ru Ma, Yang Wu, Yong-Cheng Xu, Hui-Min Gu, Di-Xian Wang et al. Neutralization of Hv1/HVCN1 With Antibody Enhances Microglia/Macrophages Myelin Clearance by Promoting Their Migration in the Brain Frontiers in Cellular Neuroscience 2021-10-22 [PMID: 34744634]
Mark L. Kovler, Andres J. Gonzalez Salazar, William B. Fulton, Peng Lu, Yukihiro Yamaguchi, Qinjie Zhou et al. Toll-like receptor 4–mediated enteric glia loss is critical for the development of necrotizing enterocolitis Science Translational Medicine 2021-09-22 [PMID: 34550727]
Lin Yang, Zhenmeiyu Li, Guoping Liu, Xiaosu Li, Zhengang Yang Developmental Origins of Human Cortical Oligodendrocytes and Astrocytes Neuroscience Bulletin 2022-01-01 [PMID: 34374948]
Marketa Kaucka, Bara Szarowska, Michaela Kavkova, Maria Eleni Kastriti, Polina Kameneva, Inga Schmidt et al. Nerve-associated Schwann cell precursors contribute extracutaneous melanocytes to the heart, inner ear, supraorbital locations and brain meninges Cellular and Molecular Life Sciences 2021-08-01 [PMID: 34274976]
S Kohnke, S Buller, D Nuzzaci, K Ridley, B Lam, H Pivonkova, MA Bentsen, KM Alonge, C Zhao, J Tadross, S Holmqvist, T Shimizo, H Hathaway, H Li, W Macklin, MW Schwartz, WD Richardson, GSH Yeo, RJM Franklin, RT Karadottir, DH Rowitch, C Blouet Nutritional regulation of oligodendrocyte differentiation regulates perineuronal net remodeling in the median eminence Cell Reports, 2021-07-13;36(2):109362. 2021-07-13 [PMID: 34260928] (IHC, Mouse)	IHC	Mouse
P Duong, KH Ma, R Ramesh, JJ Moran, S Won, J Svaren H3K27 demethylases are dispensable for activation of Polycomb-regulated injury response genes in peripheral nerve The Journal of Biological Chemistry, 2021-06-04;297(1):100852. 2021-06-04 [PMID: 34090875] (IHC, Mouse)	IHC	Mouse
KP Kim, C Li, D Bunina, HW Jeong, J Ghelman, J Yoon, B Shin, H Park, DW Han, JB Zaugg, J Kim, T Kuhlmann, RH Adams, KM Noh, SA Goldman, HR Schöler Donor cell memory confers a metastable state of directly converted cells Cell Stem Cell, 2021-04-12;0(0):. 2021-04-12 [PMID: 33848472] (ICC, Mouse)	ICC	Mouse
Tao Gao, Elizabeth C. Wright-Jin, Rajarshi Sengupta, Jessica B. Anderson, Robert O. Heuckeroth Cell-autonomous retinoic acid receptor signaling has stage-specific effects on mouse enteric nervous system JCI Insight 2021-05-24 [PMID: 33848271]
P Kameneva, AV Artemov, ME Kastriti, L Faure, TK Olsen, J Otte, A Erickson, B Semsch, ER Andersson, M Ratz, J Frisén, AS Tischler, RR de Krijger, T Bouderliqu, N Akkuratova, M Vorontsova, O Gusev, K Fried, E Sundström, S Mei, P Kogner, N Baryawno, PV Kharchenko, I Adameyko Single-cell transcriptomics of human embryos identifies multiple sympathoblast lineages with potential implications for neuroblastoma origin Nature Genetics, 2021-04-08;0(0):. 2021-04-08 [PMID: 33833454] (IHC, Human)	IHC	Human
Jun Fang, Junren Sia, Jennifer Soto, Pingping Wang, LeeAnn K. Li, Yuan-Yu Hsueh et al. Skeletal muscle regeneration via the chemical induction and expansion of myogenic stem cells in situ or in vitro Nature Biomedical Engineering 2021-03-18 [PMID: 33737730]
KJ Chang, I Agrawal, A Vainshtein, WY Ho, W Xin, G Tucker-Kel, K Susuki, E Peles, SC Ling, JR Chan TDP-43 maximizes nerve conduction velocity by repressing a cryptic exon for paranodal junction assembly in Schwann cells Elife, 2021-03-10;10(0):. 2021-03-10 [PMID: 33689679] (IHC, Mouse)	IHC	Mouse
Shashank Gandhi, Yuwei Li, Weiyi Tang, Jens B. Christensen, Hugo A. Urrutia, Felipe M. Vieceli et al. A single-plasmid approach for genome editing coupled with long-term lineage analysis in chick embryos Development 2021-04-01 [PMID: 33688075]
D. A. Maas, V. D. Eijsink, J. A. van Hulten, R. Panic, P. De Weerd, J. R. Homberg et al. Antioxidant treatment ameliorates prefrontal hypomyelination and cognitive deficits in a rat model of schizophrenia Neuropsychopharmacology 2021-05-01 [PMID: 33564104]
I Paredes, JR Vieira, B Shah, CF Ramunno, J Dyckow, H Adler, M Richter, G Schermann, E Giannakour, L Schirmer, HG Augustin, C Ruiz de Al Oligodendrocyte precursor cell specification is regulated by bidirectional neural progenitor-endothelial cell crosstalk Nature Neuroscience, 2021-01-28;0(0):. 2021-01-28 [PMID: 33510480] (IHC, Mouse)	IHC	Mouse
Laura J Wagstaff, Jose A Gomez-Sanchez, Shaline V Fazal, Georg W Otto, Alastair M Kilpatrick, Kirolos Michael et al. Failures of nerve regeneration caused by aging or chronic denervation are rescued by restoring Schwann cell c-Jun eLife 2021-01-21 [PMID: 33475496]
Ayaka Kaneko, Kiyohito Naito, Shinji Nakamura, Katsumi Miyahara, Kenji Goto, Hiroyuki Obata et al. Influence of aging on the peripheral nerve repair process using an artificial nerve conduit Experimental and Therapeutic Medicine 2020-12-21 [PMID: 33456535]
AJ Hulme, JR McArthur, S Maksour, S Miellet, L Ooi, DJ Adams, RK Finol-Urda, M Dottori Molecular and Functional Characterization of Neurogenin-2 Induced Human Sensory Neurons Frontiers in Cellular Neuroscience, 2020-12-04;14(0):600895. 2020-12-04 [PMID: 33362470] (ICC, Human)	ICC	Human
JA García-Leó, B García-Día, K Eggermont, L Cáceres-Pa, K Neyrinck, R Madeiro da, JC Dávila, A Baron-Van, A Gutiérrez, CM Verfaillie Generation of oligodendrocytes and establishment of an all-human myelinating platform from human pluripotent stem cells Nat Protoc, 2020-10-23;15(11):3716-3744. 2020-10-23 [PMID: 33097924] (ICC, Human)	ICC	Human
KC Allan, LR Hu, MA Scavuzzo, AR Morton, AS Gevorgyan, EF Cohn, BLL Clayton, IR Bederman, S Hung, CF Bartels, M Madhavan, PJ Tesar Non-canonical Targets of HIF1a Impair Oligodendrocyte Progenitor Cell Function Cell Stem Cell, 2020-10-21;0(0):. 2020-10-21 [PMID: 33091368] (Western Blot, Human)	Western Blot	Human
C. Chalfouh, C. Guillou, J. Hardouin, Q. Delarue, X. Li, C. Duclos et al. The Regenerative Effect of Trans-spinal Magnetic Stimulation After Spinal Cord Injury: Mechanisms and Pathways Underlying the Effect Neurotherapeutics 2020-10-01 [PMID: 32856173]
Patrick Walsh, Vincent Truong, Sushmita Nayak, Marietta Saldías Montivero, Walter C. Low, Ann M. Parr et al. Accelerated differentiation of human pluripotent stem cells into neural lineages via an early intermediate ectoderm population Stem Cells 2020-11-01 [PMID: 32745311]
Kathleen K. Catignas, Luciana R. Frick, Marta Pellegatta, Edward Hurley, Zachary Kolb, Kathryn Addabbo et al. alpha V integrins in Schwann cells promote attachment to axons, but are dispensable in vivo Glia 2021-01-01 [PMID: 32744761]
Zhirong Wang, Johnny S. Jung, Talya C. Inbar, Katherine M. Rangoussis, Christian Faaborg-Andersen, Thomas M. Coate The Purinergic Receptor P2rx3 is Required for Spiral Ganglion Neuron Branch Refinement during Development eNeuro 2020-07-16 [PMID: 32675174]
Matthew S. Elitt, Lilianne Barbar, H. Elizabeth Shick, Berit E. Powers, Yuka Maeno-Hikichi, Mayur Madhavan et al. Suppression of proteolipid protein rescues Pelizaeus–Merzbacher disease Nature 2020-09-17 [PMID: 32610343]
Daeha Joung, Vincent Truong, Colin C. Neitzke, Shuang-Zhuang Guo, Patrick J. Walsh, Joseph R. Monat et al. 3D Printed Stem-Cell Derived Neural Progenitors Generate Spinal Cord Scaffolds Advanced Functional Materials 9/26/2018 [PMID: 32595422]
Tou Yia Vue, Rahul K. Kollipara, Mark D. Borromeo, Tyler Smith, Tomoyuki Mashimo, Dennis K. Burns et al. ASCL1 regulates neurodevelopmental transcription factors and cell cycle genes in brain tumors of glioma mouse models Glia 2020-12-01 [PMID: 32573857]
DA Maas, VD Eijsink, M Spoelder, JA van Hulten, P De Weerd, JR Homberg, A Vallès, B Nait-Oumes, GJM Martens Interneuron hypomyelination is associated with cognitive inflexibility in a rat model of schizophrenia Nat Commun, 2020-05-11;11(1):2329. 2020-05-11 [PMID: 32393757] (ICC, Rat)	ICC	Rat
C Nagy, M Maitra, A Tanti, M Suderman, JF Théroux, MA Davoli, K Perlman, V Yerko, YC Wang, SJ Tripathy, P Pavlidis, N Mechawar, J Ragoussis, G Turecki Single-nucleus transcriptomics of the prefrontal cortex in major depressive disorder implicates oligodendrocyte precursor cells and excitatory neurons Nat. Neurosci., 2020-04-27;0(0):. 2020-04-27 [PMID: 32341540] (ICC, Human)	ICC	Human
Daniel C. Factor, Anna M. Barbeau, Kevin C. Allan, Lucille R. Hu, Mayur Madhavan, An T. Hoang et al. Cell Type-Specific Intralocus Interactions Reveal Oligodendrocyte Mechanisms in MS Cell 2020-04-03 [PMID: 32246942]
B Alshehri, M Pagnin, JY Lee, S Petratos, SJ Richardson The Role of Transthyretin in Oligodendrocyte Development Sci Rep, 2020-03-06;10(1):4189. 2020-03-06 [PMID: 32144308] (IHC, Mouse)	IHC	Mouse
Paige M. Brooks, Kevin P. Rose, Meaghan L. MacRae, Katherine M. Rangoussis, Mansa Gurjar, Ronna Hertzano et al. Pou3f4‐expressing otic mesenchyme cells promote spiral ganglion neuron survival in the postnatal mouse cochlea Journal of Comparative Neurology 2020-08-01 [PMID: 31994726]
A Tripathi, C Volsko, JP Garcia, E Agirre, KC Allan, PJ Tesar, BD Trapp, G Castelo-Br, FJ Sim, R Dutta Oligodendrocyte Intrinsic miR-27a Controls Myelination and Remyelination Cell Rep, 2019-10-22;29(4):904-919.e9. 2019-10-22 [PMID: 31644912] (IHC-P, Human, Mouse)	IHC-P	Human, Mouse
Q Wang, H Kurosaka, M Kikuchi, A Nakaya, PA Trainor, T Yamashiro Perturbed development of cranial neural crest cells in association with reduced sonic hedgehog signaling underlies the pathogenesis of retinoic-acid-induced cleft palate Dis Model Mech, 2019-10-04;12(10):. 2019-10-04 [PMID: 31591086] (IHC, Mouse)	IHC	Mouse
Andrea Ommer, Gianluca Figlia, Jorge A. Pereira, Anna Lena Datwyler, Joanne Gerber, Jonathan DeGeer et al. Ral GTPases in Schwann cells promote radial axonal sorting in the peripheral nervous system Journal of Cell Biology 2019-07-01 [PMID: 31201267]
S Wiszniak, Q Schwarz Notch signalling defines dorsal root ganglia neuroglial fate choice during early neural crest cell migration BMC Neurosci, 2019-04-29;20(1):21. 2019-04-29 [PMID: 31036074] (IHC-F, Mouse)	IHC-F	Mouse
Beatriz Garcia-Diaz, Corinne Bachelin, Fanny Coulpier, Gaspard Gerschenfeld, Cyrille Deboux, Violetta Zujovic et al. Blood vessels guide Schwann cell migration in the adult demyelinated CNS through Eph/ephrin signaling Acta Neuropathologica 2019-09-01 [PMID: 31011859]
MSY Yeung, M Djelloul, E Steiner, S Bernard, M Salehpour, G Possnert, L Brundin, J Frisén Dynamics of oligodendrocyte generation in multiple sclerosis Nature, 2019-01-23;0(0):. 2019-01-23 [PMID: 30675058] (IHC-Fr, Human)	IHC-Fr	Human
Daniel Gerber, Monica Ghidinelli, Elisa Tinelli, Christian Somandin, Joanne Gerber, Jorge A Pereira et al. Schwann cells, but not Oligodendrocytes, Depend Strictly on Dynamin 2 Function eLife 2019-01-16 [PMID: 30648534]
Debadrita Bhattacharya, Megan Rothstein, Ana Paula Azambuja, Marcos Simoes-Costa Control of neural crest multipotency by Wnt signaling and the Lin28/let-7 axis eLife 2018-12-06 [PMID: 30520734]
Donna L. McPhie, Ralda Nehme, Caitlin Ravichandran, Suzann M. Babb, Sulagna Dia Ghosh, Alexandra Staskus et al. Oligodendrocyte differentiation of induced pluripotent stem cells derived from subjects with schizophrenias implicate abnormalities in development Translational Psychiatry 2018-10-23 [PMID: 30352993]
Ki H. Ma, Phu Duong, John J. Moran, Nabil Junaidi, John Svaren Polycomb repression regulates Schwann cell proliferation and axon regeneration after nerve injury Glia 2018-11-01 [PMID: 30306639]
A Kozlenkov, J Li, P Apontes, YL Hurd, WM Byne, EV Koonin, M Wegner, EA Mukamel, S Dracheva A unique role for DNA (hydroxy)methylation in epigenetic regulation of human inhibitory neurons Sci Adv, 2018-09-26;4(9):eaau6190. 2018-09-26 [PMID: 30263963] (FACS, Human)	FACS	Human
AM Lager, OG Corradin, JM Cregg, MS Elitt, HE Shick, BLL Clayton, KC Allan, HE Olsen, M Madhavan, PJ Tesar Rapid functional genetics of the oligodendrocyte lineage using pluripotent stem cells Nat Commun, 2018-09-13;9(1):3708. 2018-09-13 [PMID: 30213958] (ICC, Mouse)	ICC	Mouse
ML Piacentino, ME Bronner Intracellular attenuation of BMP signaling via CKIP-1/Smurf1 is essential during neural crest induction PLoS Biol., 2018-06-27;16(6):e2004425. 2018-06-27 [PMID: 29949573] (IHC-P, Chicken)	IHC-P	Chicken
Chuntao Zhao, Chen Dong, Magali Frah, Yaqi Deng, Corentine Marie, Feng Zhang et al. Dual-requirement of CHD8 for Chromatin Landscape Establishment and Histone Methyltransferase Recruitment to Promote CNS Myelination and Myelin Repair Developmental Cell 2018-06-07 [PMID: 29920279]
CC Winkler, OR Yabut, SP Fregoso, HG Gomez, BE Dwyer, SJ Pleasure, SJ Franco The Dorsal Wave of Neocortical Oligodendrogenesis Begins Embryonically and Requires Multiple Sources of Sonic Hedgehog J. Neurosci., 2018-05-08;0(0):. 2018-05-08 [PMID: 29739868] (IHC, Mouse)	IHC	Mouse
C Norrmén, G Figlia, P Pfistner, JA Pereira, S Bachofner, U Suter mTORC1 is transiently reactivated in injured nerves to promote c-Jun elevation and Schwann cell dedifferentiation J. Neurosci., 2018-04-25;0(0):. 4/25/2018 [PMID: 29695414]
DP Kelenis, E Hart, M Edwards-Fl, JE Johnson, TY Vue ASCL1 regulates proliferation of NG2-glia in the embryonic and adult spinal cord Glia, 2018-04-23;0(0):. 2018-04-23 [PMID: 29683222] (IHC-Fr, Mouse)	IHC-Fr	Mouse
LM FitzPatric, KE Hawkins, JMKM Delhove, E Fernandez, C Soldati, LF Bullen, A Nohturfft, SN Waddington, DL Medina, JP Bolaños, TR McKay NF-?B Activity Initiates Human ESC-Derived Neural Progenitor Cell Differentiation by Inducing a Metabolic Maturation Program Stem Cell Reports, 2018-04-19;0(0):. 4/19/2018 [PMID: 29681545]
SY Choi, BH Bin, W Kim, E Lee, TR Lee, EG Cho Exposure of human melanocytes to UVB twice and subsequent incubation leads to cellular senescence and senescence-associated pigmentation through the prolonged p53 expression J. Dermatol. Sci., 2018-03-02;0(0):. 2018-03-02 [PMID: 29525471] (Western Blot, Human)	Western Blot	Human
M Chen, SH Laursen, M Habekost, CH Knudsen, SH Buchholdt, J Huang, F Xu, X Liu, L Bolund, Y Luo, P Nissen, F Febbraro, M Denham Central and Peripheral Nervous System Progenitors Derived from Human Pluripotent Stem Cells Reveal a Unique Temporal and Cell-Type Specific Expression of PMCAs Front Cell Dev Biol, 2018-02-06;6(0):5. 2018-02-06 [PMID: 29468158] (ICC, Human)	ICC	Human
KD Abu-Bonsra, D Zhang, AR Bjorksten, M Dottori, DF Newgreen Generation of Adrenal Chromaffin-like Cells from Human Pluripotent Stemï¿½Cells Stem Cell Reports, 2017-12-07;0(0):. 2017-12-07 [PMID: 29233551] (ICC, Human)	ICC	Human
Shashank Gandhi, Michael L. Piacentino, Felipe M. Vieceli, Marianne E. Bronner Optimization of CRISPR/Cas9 genome editing for loss-of-function in the early chick embryo Developmental Biology 2017-12-01 [PMID: 29150011]
SV Fazal, JA Gomez-Sanc, LJ Wagstaff, N Musner, G Otto, M Janz, R Mirsky, KR Jessen Graded elevation of c-Jun in Schwann cells in vivo: gene dosage determines effects on development, re-myelination, tumorigenesis and hypomyelination J. Neurosci., 2017-11-06;0(0):. 2017-11-06 [PMID: 29109239] (IHC-Fr, Mouse)	IHC-Fr	Mouse
T Mori, A Sukeda, S Sekine, S Shibata, E Ryo, H Okano, S Suzuki, N Hiraoka SOX10 Expression as Well as BRAF and GNAQ/11 Mutations Distinguish Pigmented Ciliary Epithelium Neoplasms From Uveal Melanomas Invest. Ophthalmol. Vis. Sci., 2017-10-01;58(12):5445-5451. 2017-10-01 [PMID: 29059311] (IHC-Fr, Mouse)	IHC-Fr	Mouse
G Figlia, C Norrmén, JA Pereira, D Gerber, U Suter Dual function of the PI3K-Akt-mTORC1 axis in myelination of the peripheral nervous system Elife, 2017-09-07;6(0):. 2017-09-07 [PMID: 28880149] (IHC, Mouse)	IHC	Mouse
Benjamin L. Clayton, Aaron Huang, Rejani B. Kunjamma, Ani Solanki, Brian Popko The Integrated Stress Response in Hypoxia-Induced Diffuse White Matter Injury The Journal of Neuroscience 2017-08-02 [PMID: 28720571]
Lauren E. McLane, Jennifer N. Bourne, Angelina V. Evangelou, Luipa Khandker, Wendy B. Macklin, Teresa L. Wood Loss of Tuberous Sclerosis Complex1 in Adult Oligodendrocyte Progenitor Cells Enhances Axon Remyelination and Increases Myelin Thickness after a Focal Demyelination The Journal of Neuroscience 2017-08-02 [PMID: 28694334]
ZS Nevin, DC Factor, RT Karl, P Douvaras, J Laukka, MS Windrem, SA Goldman, V Fossati, GM Hobson, PJ Tesar Modeling the Mutational and Phenotypic Landscapes of Pelizaeus-Merzbacher Disease with Human iPSC-Derived Oligodendrocytes Am. J. Hum. Genet., 2017-03-30;100(4):617-634. 2017-03-30 [PMID: 28366443] (ICC, Human)	ICC	Human
Benjamin N. Rollo, Dongcheng Zhang, Lincon A. Stamp, Trevelyan R. Menheniott, Lefteris Stathopoulos, Mark Denham et al. Enteric Neural Cells From Hirschsprung Disease Patients Form Ganglia in Autologous Aneuronal Colon Cellular and Molecular Gastroenterology and Hepatology 2016-01-01 [PMID: 28174705]
Christina Murko, Marianne E. Bronner Tissue specific regulation of the chick Sox10E1 enhancer by different Sox family members Developmental Biology 2017-02-01 [PMID: 28012818]
T Yoshikawa, Hisano Y, Iwayama Y, Toyota T, Itasaka N, Dean B Analysis of induced pluripotent stem cells carrying 22q11.2 deletion. Transl Psychiatry, 2016-11-01;6(11):e934. 2016-11-01 [PMID: 27801899] (ICC, Human)	ICC	Human
Yannick Poitelon YAP and TAZ control peripheral myelination and the expression of laminin receptors in Schwann cells Nat Neurosci, 2016-06-06;0(0):. 2016-06-06 [PMID: 27273766] (Immunoprecipitation, Rat)	Immunoprecipitation	Rat
Panagiotis Douvaras, Tomasz Rusielewicz, Kwi Hye Kim, Jeffery D. Haines, Patrizia Casaccia, Valentina Fossati Epigenetic Modulation of Human Induced Pluripotent Stem Cell Differentiation to Oligodendrocytes International Journal of Molecular Sciences 2016-04-22 [PMID: 27110779]
A Blokzijl, LE Chen, SM Gustafsdot, J Vuu, G Ullenhag, O Kämpe, U Landegren, M Kamali-Mog, H Hedstrand Elevated Levels of SOX10 in Serum from Vitiligo and Melanoma Patients, Analyzed by Proximity Ligation Assay PLoS ONE, 2016-04-25;11(4):e0154214. 2016-04-25 [PMID: 27110718] (Proximity Ligation Assay (PLA), Human)	Proximity Ligation Assay (PLA)	Human
Norianne T. Ingram, Rana R. Khankan, Patricia E. Phelps Olfactory Ensheathing Cells Express alpha 7 Integrin to Mediate Their Migration on Laminin PLOS ONE 2016-04-14 [PMID: 27078717]
Najm F, Madhavan M, Zaremba A, Shick E, Karl R, Factor D, Miller T, Nevin Z, Kantor C, Sargent A, Quick K, Schlatzer D, Tang H, Papoian R, Brimacombe K, Shen M, Boxer M, Jadhav A, Robinson A, Podojil J, Miller S, Miller R, Tesar P Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo. Nature, 2015-04-20;522(7555):216-20. 2015-04-20 [PMID: 25896324] (IHC, Human)	IHC	Human
Jun Suzuki, Katsuyasu Sakurai, Maya Yamazaki, Manabu Abe, Hitoshi Inada, Kenji Sakimura et al. Horizontal Basal Cell-Specific Deletion of Pax6 Impedes Recovery of the Olfactory Neuroepithelium Following Severe Injury Stem Cells and Development 2015-08-15 [PMID: 25808240]
Kazushi Aoto, Lisa L. Sandell, Naomi E. Butler Tjaden, Kobe C. Yuen, Kristin E. Noack Noack Watt, Brian L. Black et al. Mef2c-F10N enhancer driven beta -galactosidase (LacZ) and Cre recombinase mice facilitate analyses of gene function and lineage fate in neural crest cells Developmental Biology 2015-06-01 [PMID: 25794678]
Zou H, Feng R, Huang Y, Tripodi J, Najfeld V, Tsankova N, Jahanshahi M, Olson L, Soriano P, Friedel R Double minute amplification of mutant PDGF receptor alpha in a mouse glioma model. Sci Rep, 2015-02-16;5(0):8468. 2015-02-16 [PMID: 25683249] (IHC, Mouse)	IHC	Mouse
Hung H, Sun G, Keles S, Svaren J Dynamic regulation of Schwann cell enhancers after peripheral nerve injury. J Biol Chem, 2015-01-22;290(11):6937-50. 2015-01-22 [PMID: 25614629] (IHC, Mouse)	IHC	Mouse
Serralbo , Olivier, Marcelle , Christop Migrating cells mediate long-range WNT signaling. Development, 2014-05-01;141(10):2057-63. 2014-05-01 [PMID: 24803654] (IHC, Mouse)	IHC	Mouse
Najm , Fadi J, Lager , Angela M, Zaremba , Anita, Wyatt , Krysta, Caprariello , Andrew V, Factor , Daniel C, Karl , Robert T, Maeda , Tadao, Miller , Robert H, Tesar , Paul J Transcription factor-mediated reprogramming of fibroblasts to expandable, myelinogenic oligodendrocyte progenitor cells. Nat Biotechnol, 2013-04-14;31(5):426-33. 2013-04-14 [PMID: 23584611] (ICC, Mouse)	ICC	Mouse
Fadi J. Najm, Anita Zaremba, Andrew V. Caprariello, Shreya Nayak, Eric C. Freundt, Peter C. Scacheri et al. Rapid and robust generation of functional oligodendrocyte progenitor cells from epiblast stem cells Nature Methods 2011-11-01 [PMID: 21946668]
Nagoshi N, Shibata S, Kubota Y, Nakamura M, Nagai Y, Satoh E, Morikawa S, Okada Y, Mabuchi Y, Katoh H, Okada S, Fukuda K, Suda T, Matsuzaki Y, Toyama Y, Okano H Ontogeny and multipotency of neural crest-derived stem cells in mouse bone marrow, dorsal root ganglia, and whisker pad. Cell Stem Cell, 2008-04-10;2(0):392-403. 2008-04-10 [PMID: 18397758] (ICC, Mouse)	ICC	Mouse
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Reviews for SOX10 Antibody (AF2864) (2) 52

Average Rating: 5

(Based on 2 reviews)

We have 2 reviews tested in 1 species: Mouse.

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Immunohistochemistry-Frozen SOX10 AF2864

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IHC-Fr

Mouse

05/09/2019

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Application	Immunohistochemistry-Frozen
Sample Tested	Embryonic spinal cord
Species	Mouse
Lot	VRY0516091

Immunohistochemistry-Paraffin SOX10 AF2864

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reviewed by:
Kelli Jordan

IHC-P

Mouse

02/26/2019

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Application	Immunohistochemistry-Paraffin
Sample Tested	Mouse Pancreas
Species	Mouse
Lot	VRY081810C

Comments

Antigen retrieval: HIER, pH 6
Block: 1 hour in 2% normal donkey serum, 2 mg/ml BSA; 0.2% triton-x
Primary: 10 ug/ml in blocking buffer, overnight at 4C
Secondary: Donkey anti-goat DyLight 650, 1:300 for 1 hour

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SH-SY5Y human neuroblastoma cell line was stained with Goat Anti-Human/Mouse/RatEphrin-B2 Antigen Affinity-purified Polyclonal Antibody (Catalog #AF496,filled histogram) or Normal Goat IgG Isotype Control Antibody(Catalog # AB-108-C, open histogram), followed by Phycoerythrin-conjugatedAnti-Goat IgG Secondary Antibody (Catalog #F0107).

Goat IgG Isotype Control [Unconjugated]
AB-108-C

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	Verified Customer 05/09/2019
Application:	IHC-Fr
Species:	Mouse

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	Kelli Jordan 02/26/2019
Application:	IHC-P
Species:	Mouse

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Bioinformatics

Gene Symbol	SOX10
Uniprot	P56693()

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At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

SOX10 Antibody [Unconjugated]

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Publications for SOX10 Antibody (AF2864)(113)

Reviews for SOX10 Antibody (AF2864) (2) 52

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