RB1CC1 Antibody

FIP200 (FAK-family interacting protein of 200 kDa) appears to play several key roles related to cell growth, proliferation, development, and tumorigenesis. FIP200 was originally identified in a yeast two-hybrid screen for Pyk2 kinase interacting proteins. It was later identified as a protein that interacts with FAK (focal adhesion kinase), a signal transducing protein that mediates signals from the extracellular matrix to the cytoskeleton to influence cell motility, and cell cycle progression. FIP200 is also known as RB1CC1 (RB1-inducible coiled-coil 1) and has been found to function as a regulator of the retinoblastoma 1 (RB1) tumor suppressor. FIP200 associates with the tumor suppressor TSC1 which partners with TSC2 to antagonize the mTOR signaling pathway. FIP200 association with TSC2 promotes mTOR activity by interfering with the antagonistic effects of the TSC1-TSC2 complex.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: WB.

Showing Publications 1 - 3 of 3.

Publications using NB100-77279	Applications	Species
Thomas HE, Zhang Y, Stefely JA et al. Mitochondrial Complex I Activity Is Required for Maximal Autophagy Cell Rep 2018-08-28 [PMID: 30157433] (WB, Human)	WB	Human
Brennan LA, Kantorow WL, Chauss D et al. Spatial expression patterns of autophagy genes in the eye lens and induction of autophagy in lens cells. Mol Vis 2012-01-01 [PMID: 22815631]
Hwa Jung et al. Mol.Biol.Cell 20 (7):1992-2003. 2009-01-01 [PMID: 19225151]

Array NB100-77279

• RB1CC1 Antibodies
• RB1CC1 Lysate
• RB1CC1 Proteins