Notch-3 Antibody (1G5)

This product is produced by and distributed for Abnova, a company based in Taiwan.

This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: WB.

Showing Publications 1 - 10 of 13. Show All 13 Publications. Collapse Publications.

Publications using H00004854-M01	Applications	Species
SJ Lee, X Zhang, G Xu, J Borjigin, MM Wang A mid-position NOTCH3 truncation in inherited cerebral small vessel disease may affect the protein interactome The Journal of Biological Chemistry, 2022-12-05;0(0):102772. 2022-12-05 [PMID: 36470429]
Kenneth G, Yijie G, Andreas G et al. NOTCH3-targeted antibody drug conjugates regress tumors by inducing apoptosis in receptor cells and through transendocytosis into ligand cells. Cell Rep Med. 2021-05-18 [PMID: 34095881]
Shodai S, Satoshi H, Taiki M et al. Lunatic fringe promotes the aggregation of CADASIL NOTCH3 mutant proteins. Biochem Biophys Res Commun. 2021-04-21 [PMID: 33894418]
Shin K, Cha Y, Ban Y et al. Anti-osteoarthritis effect of a combination treatment with human adipose tissue-derived mesenchymal stem cells and thrombospondin 2 in rabbits. World J Stem Cells. 2019-12-26 [PMID: 31875872]
Nagatoshi A, Ueda M, Ueda A et al. Serum amyloid P component: A novel potential player in vessel degeneration in CADASIL. J Neurol Sci 2017-05-26 [PMID: 28716282]
Zhang X, Wang YN, Zhu JJ et al. N-acetylcysteine negatively regulates Notch3 and its malignant signaling. Oncotarget. 2016-05-24 [PMID: 27102435] (WB, Human)	WB	Human
Meng H, Zhang X, Lee SJ, Wang MM. Von Willebrand Factor Inhibits Mature Smooth Muscle Gene Expression through Impairment of Notch Signaling. PLoS One. 2013-09-23 [PMID: 24086636]
Dong H, Blaivas M, Wang MM. Bidirectional encroachment of collagen into the tunica media in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. Brain Res. 2012-03-23 [PMID: 22503071]
Tada M, Itoh S, Ishii-Watabe A et al. Functional analysis of the Notch ligand Jagged1 missense mutant proteins underlying Alagille syndrome. FEBS J. 2012-04-06 [PMID: 22487239]
Lee SJ, Meng H, Elmadhoun O et al. Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy Affecting an African American Man: Identification of a Novel 15-Base Pair NOTCH3 Duplication. Arch Neurol. 2011-12-01 [PMID: 22159056]
Watanabe-Hosomi A, Watanabe Y, Tanaka M et al. Transendocytosis is impaired in CADASIL-mutant NOTCH3. Exp Neurol. 2011-10-28 [PMID: 22079830]
Meng H, Zhang X, Hankenson KD et al. Thrombospondin2 potentiates notch3/Jagged1 signaling. J Biol Chem 284(12):7866-74. 2009-03-20 [PMID: 19147503]
Park JT, Shih IeM, Wang TL. Identification of Pbx1, a Potential Oncogene, as a Notch3 Target Gene in Ovarian Cancer. Cancer Res. 2008-11-01 [PMID: 18974129]
Show All 13 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
	5 reviewed by: Verified Customer	WB	Rat	05/26/2009	View Summary Application Western Blot Sample Tested A7R5 cells Species Rat Lot 08235-1G5

Array H00004854-M01

• Notch-3 Antibodies
• Notch-3 Protein
• Notch-3 Proteins and Enzymes