NF-H Antibody (RT97)

Neurofilaments (NFs), the intermediate filaments (IFs) specific to neurons, is the predominant cytoskeletal elements in many nerve cells. They are believed not only to confer mechanical stability, but also to play a role in determining axonal caliber. The human NF-H gene has three introns, two of which interrupt the protein-coding sequence at identical points to introns in the genes for the two smaller Neurofilament proteins, NF-M and NF-L having mol. wts predicted from their gene sequences of - 110 000, - 102 000 and - 62 000 respectively. Each type of Neurofilament contains a central a-helical 'rod' domain of - 310 amino acids, characterized by a heptad repeat in the amino acid sequence in which the first and fourth residues are apolar. Perikaryal NFs are predominantly unphosphorylated, while axonal NFs are highly phosphorylated. Defect in NFH causes susceptibility to amyotrophic lateral sclerosis. It has an important function in mature axons.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publication using NBP2-29435	Applications	Species
Ishii M, Miyashita T, Tsuchiya K et al. Histological distribution and ultrastructural features of immunoreactive terminals against RT97, a monoclonal antibody to a 200 kD neurofilament, in the spinal dorsal horn of a rat. Fukushima J Med Sci. 2004-12-01 [PMID: 15779572]

Array NBP2-29435

• NF-H Antibodies
• NF-H ELISA Kits
• NF-H Proteins