mu Opioid R/OPRM1 Antibody

Opioid receptors are the membrane proteins that mediate the pain-relieving effect of opioid drugs, such as morphine and fentanyl as well as endogenous opioid peptides enkephalins and endorphins. The effects of opiates are mediated through opioid receptors located on the plasma membrane of neurons and other peripheral cells. There are at least 3 types of opioid receptors, mu, kappa and delta, each with a distinct pharmacologic profile (1). The endogenous opioid system is involved in stress responses, in the regulation of the experience of pain, and in the action of analgesic opiate drugs. The activation of the mu-opioid receptor system was associated with reductions in the sensory and affective ratings of the pain experience, with distinct neuroanatomical involvements. Data demonstrate the central role of the mu-opioid receptors and their endogenous ligands in the regulation of sensory and affective components of the pain experience (2).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 3 applications: FLOW, ICC/IF, WB.

Showing Publications 1 - 5 of 5.

Publications using NBP1-31180	Applications	Species
Gao T, Dong L, Qian J et al. Gper in the Rostral Ventromedial Medulla is Essential for Mobilizing Descending Inhibition of Itch SSRN Journal 2020-09-25 [PMID: 34349001]
Ding X, Gao T, Gao P et al. Activation of the G Protein-Coupled Estrogen Receptor Elicits Store Calcium Release and Phosphorylation of the Mu-Opioid Receptors in the Human Neuroblastoma SH-SY5Y Cells Front Neurosci 2019-12-17 [PMID: 31920512] (ICC/IF, WB, Human)	ICC/IF, WB	Human
El-Hage Nazira, Dever Seth M, Podhaizer Elizabeth M et al. A novel bivalent HIV-1 entry inhibitor reveals fundamental differences in CCR5-u-opioid receptor interactions between human astroglia and microglia. Aids (London, England) 2013-01-01 [PMID: 23751259] (FLOW, Human)	FLOW	Human
Hauser KF, Fitting S, Dever SM et al. Opiate Drug Use and the Pathophysiology of NeuroAIDS Curr HIV Res 2012-07-01 [PMID: 22591368] (ICC/IF, Human)	ICC/IF	Human
Dever SM, Xu R, Fitting S et al. Differential expression and HIV-1 regulation of mu-opioid receptor splice variants across human central nervous system cell types. J Neurovirol 2012-06-01 [PMID: 22528479]

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Verified Customer	WB	Rat	02/21/2015	View Summary Application Western Blot Species Rat Lot 39897

Array NBP1-31180

• mu Opioid R/OPRM1 Antibodies
• mu Opioid R/OPRM1 ELISA Kits
• mu Opioid R/OPRM1 Lysates
• mu Opioid R/OPRM1 Proteins