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mu Opioid R/OPRM1 Antibody (677014) [Unconjugated]

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Western blot shows lysates of rat brain tissue. PVDF membrane was probed with 1 µg/mL of Mouse Anti-Human µ Opioid R/ OPRM1 Monoclonal Antibody (Catalog # MAB6866) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF007). A specific band was detected for µ Opioid R/OPRM1 at approximately 63 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.
Western blot shows lysates of rat brain tissue. PVDF membrane was probed with 1 µg/mL of Mouse Anti-Human µ Opioid R/ OPRM1 Monoclonal Antibody (Catalog # MAB6866) followed by HRP-conjugated Anti-Mouse IgG Secondary ...read more

Product Details

Summary
Reactivity RtSpecies Glossary
Applications WB
Clone
677014
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

View Available Formulations
Catalog# & Formulation Size Price
Carrier Free
MAB6866-SP
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mu Opioid R/OPRM1 Antibody (677014) [Unconjugated] Summary

Immunogen
Synthetic peptide corresponding to His385-Pro398 of rat μ Opioid R/OPRM1
Accession # P33535
Specificity
Detects rat μ Opioid R/OPRM1 in direct ELISAs.
Source
N/A
Isotype
IgG2a
Clonality
Monoclonal
Host
Mouse
Gene
OPRM1
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
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Applications/Dilutions

Dilutions
  • Western Blot 1 ug/mL
Publications
Read Publication using MAB6866.

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Sterile PBS to a final concentration of 0.5 mg/mL.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for mu Opioid R/OPRM1 Antibody (677014) [Unconjugated]

  • hMOP
  • KIAA0403
  • LMOR
  • MOP
  • mOpioidR
  • MOR
  • MOR1
  • M-OR-1
  • MOR-1
  • MOR1MOR
  • Mu opiate receptor
  • mu Opioid R
  • Mu opioid receptor
  • mu-type opioid receptor
  • opioid receptor, mu 1
  • OPRM
  • OPRM1

Background

The mu-type opioid receptor (MOR), also known as OPRM1, is a 60‑70 kDa variably glycosylated G protein-coupled receptor that mediates the biological effects of many alkaloid and peptide opioids including morphine. MOR is primarily expressed on neurons in the brain, spinal cord, and gastrointestinal tract as well as on immune cells. MOR activation induces analgesia, euphoria, sedation, respiratory depression, and reduced intestinal motility. Following agonist binding, MOR is phosphorylated and internalized which contributes to opioid tolerance and desensitization. OPRM1 can form heterdimers with several other 7TM GPCRs including the delta-type Opioid Receptor (DOR), Nociceptin/Orphanin Receptor (ORL1), Neurokinin 1 Receptor (NK1), Somatostatin Receptor 2 (SSTR2), Cannabinoid Receptor 1, CCR5, and the alpha 2A-Adrenergic Receptor (ADRA2A). Rat MOR shares 94% and 98% aa sequence identity with human and mouse MOR, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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mu Opioid R/OPRM1
Antibody (677014) [Un ...
MAB6866
mu Opioid R/OPRM1 Antibody (677014) [Unconjugated]
Species: Rt
Applications: WB

Publications for mu Opioid R/OPRM1 Antibody (MAB6866)(1)


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Bioinformatics

Gene Symbol OPRM1
Uniprot