Human IL-13 Quantikine ELISA Kit

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

IL-13 (Interleukin-13) plays a key role in the pathogenesis of allergy, cancer, and tissue fibrosis. It is secreted by several helper T cell subsets, NK cells, mast cells, eosinophils, basophils, and visceral smooth muscle cells. IL-13 suppresses the production of proinflammatory cytokines and other cytotoxic substances by macrophages, fibroblasts, and endothelial cells. It promotes B cell activation, immunoglobulin class switching to IgE, and the upregulation of CD23/Fc epsilon RII. IL-13 signals through a receptor complex containing IL-13 R alpha 1 and IL-4 R alpha. This complex also functions as the type 2 IL-4 receptor. IL-13 R alpha 2 binds IL-13 and prevents IL-13 from signaling through the IL-13 R alpha 1/IL-4 R alpha complex. IL-13-bound IL-13 R alpha 2 can directly promote tumor cell invasiveness and the development of tissue fibrosis.

We have publications tested in 2 confirmed species: Human, Mouse.

Showing Publications 1 - 10 of 32. Show All 32 Publications. Collapse Publications.

Publications using D1300B	Applications	Species
Irie, M;Kabata, H;Sasahara, K;Kurihara, M;Shirasaki, Y;Kamatani, T;Baba, R;Matsusaka, M;Koga, S;Masaki, K;Miyata, J;Araki, Y;Kikawada, T;Kabe, Y;Suematsu, M;Yamagishi, M;Uemura, S;Moro, K;Fukunaga, K; Annexin A1 is a cell-intrinsic metalloregulator of zinc in human ILC2s Cell reports 2023-06-07 [PMID: 37294636] (Human)		Human
Y Song, J Jiang, Q Bai, S Liu, Y Zhang, C Xu, H Piao, L Li, G Yan Gene expression profiles and bioinformatics analysis in lung samples from ovalbumin-induced asthmatic mice BMC pulmonary medicine, 2023-02-02;23(1):50. 2023-02-02 [PMID: 36726128] (Mouse)		Mouse
Q D'Arcy, M Gharaee-Ke, A Zhilin-Rot, JA Macoska The IL-4/IL-13 signaling axis promotes prostatic fibrosis PLoS ONE, 2022-10-06;17(10):e0275064. 2022-10-06 [PMID: 36201508] (Human)		Human
DH Lee, HK Park, HR Lee, H Sohn, S Sim, HJ Park, YS Shin, YK Kim, Y Choi, HS Park Immunoregulatory effects of Lactococcus lactis-derived extracellular vesicles in allergic asthma Clinical and translational allergy, 2022-03-01;12(3):e12138. 2022-03-01 [PMID: 35344296] (Human)		Human
A Kuzumi, A Yoshizaki, KM Matsuda, H Kotani, Y Norimatsu, M Fukayama, S Ebata, T Fukasawa, A Yoshizaki-, Y Asano, K Morikawa, Y Kazoe, K Mawatari, T Kitamori, S Sato Interleukin-31 promotes fibrosis and T helper 2 polarization in systemic sclerosis Nature Communications, 2021-10-12;12(1):5947. 2021-10-12 [PMID: 34642338] (Human)		Human
Y Jiang, AK Farrell, ET Tobin, HE Mair-Meije, DE Wildman, F Luca, RB Slatcher, S Zilioli Socioeconomic status, financial stress, and glucocorticoid resistance among youth with asthma: Testing the moderation effects of maternal involvement and warmth Brain, Behavior, and Immunity, 2021-05-17;0(0):. 2021-05-17 [PMID: 34015429] (Human)		Human
BK Jeong, JH Kim, MH Jung, KM Kang, YH Lee Cytokine Profiles of Non-Small Cell Lung Cancer Patients Treated with Concurrent Chemoradiotherapy with Regards to Radiation Pneumonitis Severity Journal of Clinical Medicine, 2021-02-11;10(4):. 2021-02-11 [PMID: 33670117] (Human)		Human
T Tanosaki, H Kabata, M Matsusaka, J Miyata, K Masaki, T Mochimaru, S Okuzumi, M Kuwae, R Watanabe, Y Suzuki, K Sayama, K Izuhara, K Asano, K Fukunaga Clinical characteristics of patients with not well-controlled severe asthma in Japan: Analysis of the Keio Severe Asthma Research Program in Japanese population (KEIO-SARP) registry Allergol Int, 2020-07-08;0(0):. 2020-07-08 [PMID: 32651123] (Human)		Human
T Auguet, L Bertran, J Binetti, C Aguilar, S Martínez, F Sabench, JM Lopez-Dupl, JA Porras, D Riesco, D Del Castil, C Richart Relationship between IL-8 Circulating Levels and TLR2 Hepatic Expression in Women with Morbid Obesity and Nonalcoholic Steatohepatitis Int J Mol Sci, 2020-06-11;21(11):. 2020-06-11 [PMID: 32545403] (Human)		Human
E Terzuoli, C Bellan, S Aversa, V Ciccone, L Morbidelli, A Giachetti, S Donnini, M Ziche ALDH3A1 Overexpression in Melanoma and Lung Tumors Drives Cancer Stem Cell Expansion, Impairing Immune Surveillance through Enhanced PD-L1 Output Cancers (Basel), 2019-12-06;11(12):. 2019-12-06 [PMID: 31817719] (Human)		Human
C Gabay, J Msihid, M Zilberstei, C Paccard, Y Lin, NMH Graham, A Boyapati Identification of sarilumab pharmacodynamic and predictive markers in patients with inadequate response to TNF inhibition: a biomarker substudy of the phase 3 TARGET study RMD Open, 2018-03-14;4(1):e000607. 2018-03-14 [PMID: 29556418] (Human)		Human
J Milara, G Hernandez, B Ballester, A Morell, I Roger, P Montero, J Escrivá, JM Lloris, M Molina-Mol, E Morcillo, J Cortijo The JAK2 pathway is activated in idiopathic pulmonary fibrosis Respir. Res., 2018-02-06;19(1):24. 2018-02-06 [PMID: 29409529] (Human)		Human
H Nakamura, K Akashi, M Watanabe, S Ohta, J Ono, Y Azuma, N Ogasawara, K Yamamoto, N Shimizu, H Tsutsumi, K Izuhara, T Katsunuma Up-regulation of serum periostin and squamous cell carcinoma antigen levels in infants with acute bronchitis due to respiratory syncytial virus Allergol Int, 2017-11-06;0(0):. 2017-11-06 [PMID: 29122495] (Human)		Human
Bu X, Zhang T, Wang C, Ren T, Wen Z IL-33 reflects dynamics of disease activity in patients with autoimmune hemolytic anemia by regulating autoantibody production. J Transl Med, 2015-12-16;13(0):381. 2015-12-16 [PMID: 26675669] (Human)		Human
Biancheri P, Di Sabatino A, Ammoscato F, Facciotti F, Caprioli F, Curciarello R, Hoque S, Ghanbari A, Joe-Njoku I, Giuffrida P, Rovedatti L, Geginat J, Corazza G, MacDonald T Absence of a role for interleukin-13 in inflammatory bowel disease. Eur J Immunol, 2014-02-01;44(2):370-85. 2014-02-01 [PMID: 24338958] (Human)		Human
Takei S, Hoshino T, Matsunaga K, Sakazaki Y, Sawada M, Oda H, Takenaka S, Imaoka H, Kinoshita T, Honda S, Ida H, Fukuda TA, Aizawa H Soluble interleukin-18 receptor complex is a novel biomarker in rheumatoid arthritis. Arthritis Res. Ther., 2011-03-24;13(2):R52. 2011-03-24 [PMID: 21435242] (Human)		Human
Semlali A, Jacques E, Koussih L, Gounni AS, Chakir J Thymic stromal lymphopoietin-induced human asthmatic airway epithelial cell proliferation through an IL-13-dependent pathway. J. Allergy Clin. Immunol., 2010-03-17;125(4):844-50. 2010-03-17 [PMID: 20236697] (Human)		Human
Margulis A, Nocka KH, Brennan AM, Deng B, Fleming M, Goldman SJ, Kasaian MT Mast cell-dependent contraction of human airway smooth muscle cell-containing collagen gels: influence of cytokines, matrix metalloproteases, and serine proteases. J. Immunol., 2009-07-10;183(3):1739-50. 2009-07-10 [PMID: 19592653] (Human)		Human
Eyerich K, Pennino D, Scarponi C, Foerster S, Nasorri F, Behrendt H, Ring J, Traidl-Hoffmann C, Albanesi C, Cavani A IL-17 in atopic eczema: linking allergen-specific adaptive and microbial-triggered innate immune response. J. Allergy Clin. Immunol., 2008-12-03;123(1):59-66.e4. 2008-12-03 [PMID: 19056110] (Human)		Human
Yokoi T, Amakawa R, Tanijiri T, Sugimoto H, Torii Y, Amuro H, Son Y, Tajima K, Liu YJ, Ito T, Fukuhara S Mycobacterium bovis Bacillus Calmette-Guerin suppresses inflammatory Th2 responses by inducing functional alteration of TSLP-activated dendritic cells. Int. Immunol., 2008-08-13;20(10):1321-9. 2008-08-13 [PMID: 18703465] (Human)		Human
Ingvarsson J, Wingren C, Carlsson A, Ellmark P, Wahren B, Engstrom G, Harmenberg U, Krogh M, Peterson C, Borrebaeck CA Detection of pancreatic cancer using antibody microarray-based serum protein profiling. Proteomics, 2008-06-01;8(11):2211-9. 2008-06-01 [PMID: 18528842] (Human)		Human
Miller R, Sadhukhan R, Wu C Development of an in vitro potency bioassay for therapeutic IL-13 antagonists: the A-549 cell bioassay. J. Immunol. Methods, 2008-03-07;334(1):134-41. 2008-03-07 [PMID: 18355834] (Human)		Human
Liu TY, Uemura Y, Suzuki M, Narita Y, Hirata S, Ohyama H, Ishihara O, Matsushita S Distinct subsets of human invariant NKT cells differentially regulate T helper responses via dendritic cells. Eur. J. Immunol., 2008-04-01;38(4):1012-23. 2008-04-01 [PMID: 18350544] (Human)		Human
Blanchard C, Mingler MK, Vicario M, Abonia JP, Wu YY, Lu TX, Collins MH, Putnam PE, Wells SI, Rothenberg ME IL-13 involvement in eosinophilic esophagitis: transcriptome analysis and reversibility with glucocorticoids. J. Allergy Clin. Immunol., 2007-12-01;120(6):1292-300. 2007-12-01 [PMID: 18073124] (Human)		Human
Lin YL, Liang YC, Chiang BL Placental growth factor down-regulates type 1 T helper immune response by modulating the function of dendritic cells. J. Leukoc. Biol., 2007-08-30;82(6):1473-80. 2007-08-30 [PMID: 17761954] (Human)		Human
Benson M, Langston MA, Adner M, Andersson B, Torinssson-Naluai A, Cardell LO A network-based analysis of the late-phase reaction of the skin. J. Allergy Clin. Immunol., 2006-05-11;118(1):220-5. 2006-05-11 [PMID: 16815159] (Human)		Human
Hartl D, Latzin P, Zissel G, Krane M, Krauss-Etschmann S, Griese M Chemokines indicate allergic bronchopulmonary aspergillosis in patients with cystic fibrosis. Am. J. Respir. Crit. Care Med., 2006-03-16;173(12):1370-6. 2006-03-16 [PMID: 16543550] (Human)		Human
Yamanaka K, Clark R, Dowgiert R, Hurwitz D, Shibata M, Rich BE, Hirahara K, Jones DA, Eapen S, Mizutani H, Kupper TS Expression of interleukin-18 and caspase-1 in cutaneous T-cell lymphoma. Clin. Cancer Res., 2006-01-15;12(2):376-82. 2006-01-15 [PMID: 16428475] (Human)		Human
Bedaiwy MA, Falcone T, Goldberg JM, Attaran M, Sharma R, Miller K, Nelson DR, Agarwal A Relationship between cytokines and the embryotoxicity of hydrosalpingeal fluid. J. Assist. Reprod. Genet., 2005-04-01;22(4):161-5. 2005-04-01 [PMID: 16021860] (Human)		Human
Ripley D, Shoup B, Majewski A Differential expression of interleukins IL-13 and IL-15 in normal ovarian tissue and ovarian carcinomas. Gynecol. Oncol., 2004-03-01;92(3):761-8. 2004-03-01 [PMID: 14984938] (Human)		Human
Tain YL, Chen TY, Yang KD Implications of serum TNF-beta and IL-13 in the treatment response of childhood nephrotic syndrome. Cytokine, 2003-02-07;21(3):155-9. 2003-02-07 [PMID: 12697154] (Human)		Human
Rigano R, Profumo E, Bruschi F, Carulli G, Azzara A, Ioppolo S, Buttari B, Ortona E, Margutti P, Teggi A, Siracusano A Modulation of human immune response by Echinococcus granulosus antigen B and its possible role in evading host defenses. Infect. Immun., 2001-01-01;69(1):288-96. 2001-01-01 [PMID: 11119517] (Human)		Human
Show All 32 Publications. Collapse Publications.

Array D1300B

• IL-13 Antibodies
• IL-13 Antibody Pair
• IL-13 ELISA Kits
• IL-13 Lysate
• IL-13 Proteins
• IL-13 Proteins and Enzymes
• IL-13 ELISAs