HERC5 Antibody

This product is produced by and distributed for Abnova, a company based in Taiwan.

This gene is a member of the HERC family of ubiquitin ligases and encodes a protein with a HECT domain and five RCC1 repeats. Pro-inflammatory cytokines upregulate expression of this gene in endothelial cells. The protein localizes to the cytoplasm and perinuclear region and functions as an interferon-induced E3 protein ligase that mediates ISGylation of protein targets. The gene lies in a cluster of HERC family genes on chromosome 4.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: WB.

Showing Publications 1 - 7 of 7.

Publications using H00051191-A01	Applications	Species
Jeon SJ, Chung KC. Covalent conjugation of ubiquitin-like ISG15 to apoptosis-inducing factor exacerbates toxic stimuli-induced apoptotic cell death Journal of Biological Chemistry 2022-10-01 [PMID: 36075291]
F El-Asmi, FP McManus, CE Brantis-de, JC Valle-Casu, P Thibault, MK Chelbi-Ali Cross-talk between SUMOylation and ISGylation in response to interferon Cytokine, 2020-02-07;129(0):155025. 2020-02-07 [PMID: 32044670]
Park SY, Yoon S, Kim H, Kim KK. 90K Glycoprotein Promotes Degradation of Mutant B-Catenin Lacking the ISGylation or Phosphorylation Sites in the N-terminus. Neoplasia 2016-09-23 [PMID: 27668402]
Im E, Yoo L, Hyun M et al. Covalent ISG15 conjugation positively regulates the ubiquitin E3 ligase activity of parkin. Open Biol 2016-08-01 [PMID: 27534820] (WB)	WB
Woods MW, Tong JG, Tom SK et al. Interferon-induced HERC5 is evolving under positive selection and inhibits HIV-1 particle production by a novel mechanism targeting Rev/RRE-dependent RNA nuclear export. Retrovirology. 2014-04-03 [PMID: 24693865]
Woods MW, Kelly JN, Hattlmann CJ et al. Human HERC5 restricts an early stage of HIV-1 assembly by a mechanism correlating with the ISGylation of Gag. Retrovirology. 2011-11-17 [PMID: 22093708]
Gao J, Wang HL, Shreve A et al. Fullerene derivatives induce premature senescence: a new toxicity paradigm or novel biomedical applications Toxicol Appl Pharmacol. 2010-04-15 [PMID: 20045429] (WB, Human)	WB	Human

Array H00051191-A01

• HERC5 Antibodies
• HERC5 Proteins