GABA-A R delta Antibody

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA Receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date six as, four bs and four gs, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990; Whiting et al., 1999; Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for a- and b-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a g-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different a-subunits of the receptor (McKernan et al., 2000; Mehta and Ticku, 1998; Ogris et al., 2004; Poltl et al., 2003). More recently there have been a number of studies demonstrating that the a-subunit of the receptor may affect subunit assembly (Korpi et al., 2002) and may also confer differential sensitivity to neurosteroids and to ethanol (Wallner et al., 2003; Wohlfarth et al., 2002).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 5 applications: B/N, ICC/IF, IF/IHC, Knockout Validated, WB.

Showing Publications 1 - 10 of 15. Show All 15 Publications. Collapse Publications.

Publications using NB300-200	Applications	Species
Crofton EJ, O'Buckley TK, Bohnsack JP et al. Divergent Population-Specific Effects of Chronic Ethanol Exposure on Excitability and Inhibitory Transmission in Male and Female Rat Central Amygdala The Journal of neuroscience : the official journal of the Society for Neuroscience 2023-09-01 [PMID: 37657933] (WB)	WB
Lacaille H, Vacher CM, Penn AA. Preterm Birth Alters the Maturation of the GABAergic System in the Human Prefrontal Cortex Frontiers in Molecular Neuroscience 2022-02-03 [PMID: 35185465] (WB, B/N)	WB, B/N
Michalettos G, Walter HL, Antunes ARP Et al. Effect of Anti-inflammatory Treatment with AMD3100 and CX3CR1 Deficiency on GABAA Receptor Subunit and Expression of Glutamate Decarboxylase Isoforms After Stroke Molecular neurobiology 2021-08-20 [PMID: 34417725] (WB, Mouse)	WB	Mouse
Sharma D, Dixit AB, Dey S et al. Increased levels of alpha 4-containing GABAA receptors in focal cortical dysplasia: A possible cause of benzodiazepine resistance Neurochemistry international 2021-05-27 [PMID: 34052299]
Morrison, K E, Cole, A B Et al. Pubertal adversity alters chromatin dynamics and stress circuitry in the pregnant brain. Neuropsychopharmacology 2020-07-01 [PMID: 32045935] (WB, Human)	WB	Human
Trent S, Hall J, Connelly WM, Errington AC Cyfip1 Haploinsufficiency Does Not Alter GABAA Receptor delta-Subunit Expression and Tonic Inhibition in Dentate Gyrus PV+ Interneurons and Granule Cells G3 (Bethesda). 2019-06-28 [PMID: 31209152] (WB, Knockout Validated, Mouse)	WB, Knockout Validated	Mouse
Chen X, Li Z, Zhang B et al. Alleviation of mechanical allodynia by 14,15-EET in a central post-stroke pain model: possible role of allopregnanolone and dGABAAR J Pain 2018-11-27 [PMID: 30500366] (WB, Rat)	WB	Rat
Popoola DO, Cameron NM. Maternal care-related differences in males and females rats' sensitivity to ethanol and the associations between the GABAergic system and steroids in males. Dev Psychobiol. 2018-02-14 [PMID: 29442358] (WB, Rat)	WB	Rat
Popoola DO, Nizhnikov ME, Cameron NM. Strain-specific programming of prenatal ethanol exposure across generations. Alcohol: An International Biomedical Journal 2017-01-03 [PMID: 28433421] (WB, Rat)	WB	Rat
Borrow AP, Cameron NM, . Maternal care and affective behavior in female offspring: Implication of the neurosteroid/GABAergic system. Psychoneuroendocrinology 2017-02-01 [PMID: 27883962]
Chugh D, Ali I, Bakochi A et al. Alterations in Brain Inflammation, Synaptic Proteins, and Adult Hippocampal Neurogenesis during Epileptogenesis in Mice Lacking Synapsin2. PLoS ONE 2015-07-16 [PMID: 26177381] (WB, Mouse)	WB	Mouse
Carlson SL, O'Buckley TK, Thomas R et al. Altered GABAA Receptor Expression and Seizure Threshold Following Acute Ethanol Challenge in Mice Lacking the RIIbeta Subunit of PKA. Neurochem Res. 2013-10-09 [PMID: 24104609] (WB, Mouse)	WB	Mouse
Shen H, Mohammad A, Ramroop J, Smith SS. A stress steroid triggers anxiety via increased expression of alpha4betadelta GABAA receptors in methamphetamine dependence. Neuroscience. 2013-08-28 [PMID: 23994152] (WB, Rat)	WB	Rat
Aarti Kuver, Hui Shen, Sheryl S. Smith Regulation of the surface expression of ?4?2? GABAA receptors by high efficacy states Brain Research 2021-06-29 [PMID: 22609410] (ICC/IF, Human)	ICC/IF	Human
Herman MA, Gillis RA, Vicini S, Dretchen KL, Sahibzada N. Tonic GABAA receptor conductance in medial subnucleus of the tractus solitarius neurons is inhibited by activation of ?-opioid receptors. J Neurophysiol;107(3):1022-31. 2012-02-01 [PMID: 22114164] (IF/IHC, Rat)	IF/IHC	Rat
Show All 15 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Daniel Popoola	WB	Rat	01/31/2017	View Summary Application Western Blot Sample Tested Adolescent and adult cerebellum Species Rat
Enlarge	4 reviewed by: Daniel Popoola	WB	Rat	09/26/2014	View Summary Application Western Blot Sample Tested Rat brain synaptosomal (P2) fraction Species Rat

Array NB300-200

• GABA-A R delta Antibodies
• GABA-A R delta Protein