FXR/NR1H4 Antibody (1B10)

This product is produced by and distributed for Abnova, a company based in Taiwan.

FXR and LXR fall into a category of proteins termed orphan receptors; because of their lack of a defined function, and in the case of LXR, the lack of a defined ligand. FXR has been shown to bind a class of lipid molecules called farnesoids. LXR/RXR heterodimers have highest affinity for DR-4 DNA elements while FXR/RXR heterodimers bind IR-1 elements. Both LXR/RXR and FXR/RXR heterodimers retain their responsiveness to 9-cis retinoic acid. The steroid receptor superfamily acts through direct association with DNA sequences known as hormone response elements (HREs) and bind DNA as either homo- or heterodimers. The promiscuous mediator of heterodimerization, RXR, is the receptor for 9-cis retinoic acid, and dimerizes with VDR, TR, PPAR, as well as several novel receptors including LXR (also referred to as RLD-1) and FXR.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 application: WB.

Showing Publications 1 - 2 of 2.

Publications using H00009971-M02	Applications	Species
Oehler N, Volz T, Bhadra OD et al. Binding of hepatitis B virus to its cellular receptor alters the expression profile of genes of the bile acid metabolism. Hepatology. 2014-05-19 [PMID: 24711282]
Chen Y, Song X, Valanejad L et al. Bile salt export pump is dysregulated with altered farnesoid X receptor isoform expression in patients with hepatocellular carcinoma. Hepatology. 2013-04-01 [PMID: 23213087] (WB)	WB

Array H00009971-M02

• FXR/NR1H4 Antibodies
• FXR/NR1H4 ELISA Kits
• FXR/NR1H4 Lysate
• FXR/NR1H4 Proteins