LRH-1/NR5A2 Antibody

NR5A2 is a member of the so-called NR5A family of nuclear receptors. NR5A2, also call LRH1 or Liver Receptor Homolog 1, appears to play an important role in regulating pancreatic and embryonal stem cell differentiation maintaining a pluripotential or undifferentiated state. It also plays a role in controlling cholesterol balance (1, 2). NR5A2 may control pluripotentiality through its regulation of Oct4 and Nanog, both are commonly held as requisite factors for maintenance of stem cell undifferentiated states (3). Additionally, NR5A2 has a role in colon, pancreatic and breast cancer, accompanied by overexpression in the latter in ductal carcinomas (4, 5). Antibody to NR5A2 provides a tool to link expression and function with undifferentiated states in embryonic stem cells or in cancers of the breast, intestine, and pancreas, and for further characterization of NR5A2 as a potential biomarker.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Porcine.

We have publications tested in 2 applications: KD, WB.

Showing Publication 1 - 1 of 1.

Publication using NBP2-27196	Applications	Species
Guo R, Chen F, Shi Z Suppression of Notch Signaling Stimulates Progesterone Synthesis by Enhancing the Expression of NR5A2 and NR2F2 in Porcine Granulosa Cells Genes (Basel) 2020-01-22 [PMID: 31978970] (KD, WB, Porcine)	KD, WB	Porcine

Array NBP2-27196

• LRH-1/NR5A2 Antibodies
• LRH-1/NR5A2 Lysate
• LRH-1/NR5A2 Protein