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Fc gamma RI/CD64 Antibody (H22) [Alexa Fluor® 750]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow, ICC/IF, ELISA(Comp)
Clone
H22
Clonality
Monoclonal
Host
Rabbit
Conjugate
Alexa Fluor 750

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP2-81098AF350
Alexa Fluor 405
NBP2-81098AF405
Alexa Fluor 488
NBP2-81098AF488
Alexa Fluor 532
NBP2-81098AF532
Alexa Fluor 594
NBP2-81098AF594
Alexa Fluor 647
NBP2-81098AF647
Alexa Fluor 700
NBP2-81098AF700
Allophycocyanin
NBP2-81098APC
Biotin
NBP2-81098B
CoraFluor 1
NBP2-81098CL1
DyLight 350
NBP2-81098UV
DyLight 405
NBP2-81098V
DyLight 488
NBP2-81098G
DyLight 550
NBP2-81098R
DyLight 594
NBP2-81098DL594
DyLight 650
NBP2-81098C
DyLight 680
NBP2-81098FR
DyLight 755
NBP2-81098IR
FITC
NBP2-81098F
HRP
NBP2-81098H
Janelia Fluor 525
NBP2-81098JF525
Janelia Fluor 549
NBP2-81098JF549
Janelia Fluor 585
NBP2-81098JF585
Janelia Fluor 635
NBP2-81098JF635
Janelia Fluor 646
NBP2-81098JF646
Janelia Fluor 669
NBP2-81098JF669
PE
NBP2-81098PE
PerCP
NBP2-81098PCP
Unconjugated
NBP2-81098-0.2mg
mFluor Violet 450 SE
NBP2-81098MFV450
mFluor Violet 500 SE
NBP2-81098MFV500
mFluor Violet 610 SE
NBP2-81098MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NBP2-81098-0.2mg
Azide and BSA Free
NBP2-81098-0.2mg
Azide and BSA Free
NBP2-81098-0.025mg
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Fc gamma RI/CD64 Antibody (H22) [Alexa Fluor® 750] Summary

Additional Information
Recombinant Monoclonal Antibody
Immunogen
This recombinant antibody was prepared by cloning the single chain fragment (scFv) derived from the murine anti-human Fc gamma RI/CD64 mAb m22 into the bacterial expression vector pBM1.1, and fusing it to a deletion mutant of Pseudomonas exotoxin A.
Specificity
This immunotoxin is specific for human Fc gamma RI/CD64, and specifically an epitope outside the Fc binding domain. The binding activity of the VH/VL antibody format was unaffected by fusion of the m22(scFv) coding regions to the truncated ETA coding sequences
Isotype
IgG Kappa
Clonality
Monoclonal
Host
Rabbit
Gene
FCGR1A
Purity
Protein A purified
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Applications/Dilutions

Dilutions
  • Competitive ELISA
  • Flow Cytometry
  • Immunocytochemistry/ Immunofluorescence
Application Notes
Optimal dilution of this antibody should be experimentally determined. This antibody binds human CD64 and can be bound to a toxin so that together it displays specific cytotoxicity, and thus can be used to selectively eliminate AML cells; FC analysis indicated that this immunotoxin drove 41% of primary leukemia cells from a patient with CD64-positive AML into early apoptosis (Tur, 2003). Similarly, in an in vivo mouse model, IHC analysis revealed efficient elimination of human CD64+ tumor cells in mouse organs (Tur, 2011).

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A purified

Notes



Alexa Fluor (R) products are provided under an intellectual property license from Life Technologies Corporation. The purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: (i) in manufacturing; (ii) to provide a service, information, or data in return for payment; (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5791 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@lifetech.com. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for Fc gamma RI/CD64 Antibody (H22) [Alexa Fluor® 750]

  • CD64 antigen
  • CD64
  • CD64a
  • Fc fragment of IgG, high affinity Ia, receptor (CD64)
  • Fc gamma RI
  • FCG1
  • Fc-gamma receptor I B2
  • Fc-gamma RI
  • Fc-gamma RIA
  • FcgammaRIa
  • FCGR1
  • FcgRI
  • FcgRIA
  • FCRI
  • FcRIA
  • FLJ18345
  • high affinity Ia, receptor for (CD64)
  • high affinity immunoglobulin gamma Fc receptor I
  • IgG Fc receptor I

Background

CD64 is a 72 kD single chain type I glycoprotein also known as Fc gammaRI and FcR I. CD64 is a member of the immunoglobulin superfamily and is expressed on monocytes/macrophages, dendritic cells, and activated granulocytes. The expression can be upregulated by IFN- gamma stimulation. CD64 binds IgG immune complex. It plays a role in antigen capture, phagocytosis of IgG/antigen complexes, and antibody-dependent cellular cytotoxicity (ADCC).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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NBP2-81098AF750
Fc gamma RI/CD64 Antibody (H22) [Alexa Fluor® 750]
Species: Hu
Applications: Flow, ICC/IF, ELISA(Comp)

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Video Protocols

ICC/IF Video Protocol

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Bioinformatics

Gene Symbol FCGR1A