Beclin 1 Antibody - BSA Free

Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. Beclin-1, a coiled-coil Bcl-2-interacting protein homologous to the yeast autophagy gene apg6, is a mammalian autophagy gene that can inhibit tumorigenesis and is expressed at reduced levels in human breast carcinoma, suggesting that defects in autophagy proteins may contribute to the development or progression of tumors. Bcl-2 can bind to Beclin-1 and inhibit Beclin-1-dependent autophagy in yeast and mammalian cells, suggesting that Bcl-2 functions as an anti-autophagy protein as well as an anti-apoptotic protein, which helps maintain autophagy at levels that are more compatible with cell survival rather than cell death.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Rat.

We have publications tested in 1 application: WB.

Showing Publications 1 - 2 of 2.

Publications using NBP1-76648	Applications	Species
Lu JH, Wu YH, Juan TJ et al. Autophagy Alters Bladder Angiogenesis and Improves Bladder Hyperactivity in the Pathogenesis of Ketamine-Induced Cystitis in a Rat Model Biology (Basel) 2021-05-30 [PMID: 34070854]
Ben Salem I, Boussabbeh M, Da Silva JP et al. SIRT1 protects cardiac cells against apoptosis induced by zearalenone or its metabolites alpha- and beta-zearalenol through an autophagy-dependent pathway. Toxicol. Appl. Pharmacol. 2016-11-23 [PMID: 27889531] (WB, Rat) Details: This citation used the HRP version of this antibody.	WB	Rat

Array NBP1-76648

• Beclin 1 Antibodies
• Beclin 1 Antibody Packs
• Beclin 1 ELISA Kits
• Beclin 1 Lysate
• Beclin 1 Proteins