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Aurora A Antibody [Biotin]

 
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Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB, Simple Western, ICC/IF, IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
Biotin

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP1-51843AF350
Alexa Fluor 405
NBP1-51843AF405
Alexa Fluor 488
NBP1-51843AF488
Alexa Fluor 532
NBP1-51843AF532
Alexa Fluor 594
NBP1-51843AF594
Alexa Fluor 647
NBP1-51843AF647
Alexa Fluor 700
NBP1-51843AF700
Alexa Fluor 750
NBP1-51843AF750
Allophycocyanin
NBP1-51843APC
CoraFluor 1
NBP1-51843CL1
DyLight 350
NBP1-51843UV
DyLight 405
NBP1-51843V
DyLight 488
NBP1-51843G
DyLight 550
NBP1-51843R
DyLight 594
NBP1-51843DL594
DyLight 650
NBP1-51843C
DyLight 680
NBP1-51843FR
DyLight 755
NBP1-51843IR
FITC
NBP1-51843F
HRP
NBP1-51843H
Janelia Fluor 525
NBP1-51843JF525
Janelia Fluor 549
NBP1-51843JF549
Janelia Fluor 585
NBP1-51843JF585
Janelia Fluor 635
NBP1-51843JF635
Janelia Fluor 646
NBP1-51843JF646
Janelia Fluor 669
NBP1-51843JF669
PE
NBP1-51843PE
PerCP
NBP1-51843PCP
Unconjugated
NBP1-51843
mFluor Violet 450 SE
NBP1-51843MFV450
mFluor Violet 500 SE
NBP1-51843MFV500
mFluor Violet 610 SE
NBP1-51843MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NBP1-51843
BSA Free
NBP1-51843SS
BSA Free
NBP1-51843
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Aurora A Antibody [Biotin] Summary

Immunogen
A recombinant protein made to an N-terminal region of the human Aurora A protein (within residues 50-200). [Swiss-Prot O14965]
Localization
Centrosome, Spindle pole. Note: Detected at the neurite hillock in developing neurons. Localizes on centrosomes in interphase cells and at each spindle pole in mitosis.
Marker
Mitosis Marker
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
AURKA
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Simple Western
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for Aurora A Antibody [Biotin]

  • AIK
  • AIKAurA
  • ARK1
  • ARK-1
  • ARK1EC 2.7.11.1
  • AURA
  • AURKA
  • Aurora A
  • aurora kinase AhARK1
  • aurora/IPL1-like kinase
  • Aurora/IPL1-related kinase 1
  • Aurora-related kinase 1
  • Breast tumor-amplified kinase
  • breast-tumor-amplified kinase
  • BTAK
  • BTAKAURORA2
  • EC 2.7.11
  • IPL1-related kinase
  • serine/threonine kinase 6
  • serine/threonine protein kinase 15
  • Serine/threonine-protein kinase 15
  • serine/threonine-protein kinase 6
  • Serine/threonine-protein kinase aurora-A
  • STK15
  • STK15serine/threonine kinase 15
  • STK6
  • STK6MGC34538
  • STK7

Background

Aurora A is a cytoplasmic serine/threonine kinase that is critical in transitioning cells through mitosis and meiosis. Aurka acts through phosphorylating several spindle and tubulin proteins. Without Aurka, axon and neuron formation are negatively impacted. When these critical cellular processes are disrupted, there is a potential for tumorgenesis, and thus Aurka is implicated in many cancers, particularly those of the blood. In studies of angiofibromas, both MDM1 and Aurka were amplified. Overall, cell proliferation seems proportional to the expression of Aurka.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol AURKA