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AKAP5 Antibody

Images

 
Immunohistochemistry-Paraffin: AKAP5 Antibody [NBP2-38713] - Staining of human pancreas shows low expression as expected.
Immunohistochemistry: AKAP5 Antibody [NBP2-38713] - Staining of human cerebral cortex shows strong cytoplasmic and nuclear positivity in neuronal cells.
Orthogonal Strategies: Immunohistochemistry-Paraffin: AKAP5 Antibody [NBP2-38713] - Staining in human cerebral cortex and pancreas tissues using anti-AKAP5 antibody. Corresponding AKAP5 RNA-seq data are presented ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Validated by:
       

Orthogonal Strategies

 

Order Details

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AKAP5 Antibody Summary

Immunogen
This antibody was developed against a recombinant protein corresponding to amino acids: LDIQTQTPLNDQATKAKSTQDLSEGISRKDGDEVCESNVSNSITSGEKVISVELGLDNGHSAIQTGTLILEEIE
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
AKAP5
Purity
Immunogen affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:50 - 1:200
  • Immunohistochemistry-Paraffin 1:50 - 1:200
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Control Peptide
AKAP5 Protein (NBP2-38713PEP)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2) and 40% Glycerol
Preservative
0.02% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for AKAP5 Antibody

  • A kinase (PRKA) anchor protein 5
  • AKAP 79
  • AKAP7979kDa
  • A-kinase anchor protein 79 kDa
  • A-kinase anchoring protein 75/79
  • cAMP-dependent protein kinase regulatory subunit II high affinity bindingprotein
  • cAMP-dependent protein kinase regulatory subunit II high affinity-bindingprotein
  • H21

Background

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to the RII-beta regulatory subunit of PKA, and also to protein kinase C and the phosphatase calcineurin. It is predominantly expressed in cerebral cortex and may anchor the PKA protein at postsynaptic densities (PSD) and be involved in the regulation of postsynaptic events. It is also expressed in T lymphocytes and may function to inhibit interleukin-2 transcription by disrupting calcineurin-dependent dephosphorylation of NFAT. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

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Blogs on AKAP5.

Identifying tumoral and stromal transcriptomes that underlie tumor plasticity and stromal neuroinflammatory response in brain metastasis
By Jamshed Arslan, Pharm. D., PhD. Cancers in the brain often come from tumors elsewhere in the body. Several adaptive mechanisms influence brain metastasis, such as blood brain barrier leakage that can be induced by ...  Read full blog post.

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Bioinformatics

Gene Symbol AKAP5
Uniprot