Smoothened Products

Description

Smoothened, a Frizzled Receptor, is homologous to the Drosophila segment polarity Smo gene. It associates with the Patched protein to mediate the cellular response to the Hedgehog secreted protein signal, which controls patterning and growth during vertebrate development. Smoothened is activated in a number of human tumors and can function as an oncogene in basal-cell carcinomas. Smoothened expression has been documented in bladder, blood, brain, the central nervous system, skin, and ureter. ESTs have been isolated from amnion, bone, brain, breast, embryo, eye, heart, nerve, and skin libraries.

Bioinformatics

Entrez	25273 Rat 319757 Mouse 539308 Bovine 6608 Human
Uniprot	AAH09989 Human NP_005622 Human NP_005622.1 Human Q99835 Human
Product By Gene ID	6608
Alternate Names	Gx Protein Gx SMOHseven transmembrane helix receptor smoothened (Drosophila) homolog smoothened homolog (Drosophila) smoothened homolog

Research Areas for Smoothened

Find related products by research area and learn more about each of the different research areas below.

GPCR
Growth and Development
Neuronal Cell Markers

Related Smoothened Blog Posts

Check out the latest blog posts on Smoothened.

The role of Smoothened in pulmonary pathologies The Hedgehog (Hh) family of secreted proteins is involved in a number of developmental processes, one of which is the development of cancer. Past data suggests that the Sonic hedgehog (Shh) receptor is composed of two transmembrane proteins, Patche...    Read more.

Pancreatic Cancer Research Targets Hedgehog Signaling Pathway The Hedgehog Signaling Pathway (HSP) is an important pathway involved in embryonic development by regulating cell differentiation. This pathway has also become an increasingly hot topic in cancer research in recent years. The HSP involves the interact...    Read more.

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