Species: Hu, Bv, Pa
Applications: WB, ELISA, ICC/IF, IHC
Host: Mouse Monoclonal
Species: Hu
Applications: WB
Host: Goat Polyclonal
Species: Hu, Mu, Rt
Applications: WB, IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: WB
Species: Hu
Applications: AC
Description
MAP4K4 is encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified.
Bioinformatics
| Entrez |
Mouse
Human
|
| Uniprot |
Human
Human
Human
|
| Product By Gene ID |
9448 |
| Alternate Names |
- EC 2.7.11
- EC 2.7.11.1
- FLH21957
- FLJ10410
- hepatocyte progenitor kinase-like/germinal center kinase-like kinase
- HGKFLJ20373
- HPK/GCK-like kinase HGK
- KIAA0687
- MAPK/ERK kinase kinase kinase 4
- MEK kinase kinase 4
- MEKKK 4
- mitogen-activated protein kinase kinase kinase kinase 4
- Nck-interacting kinase
- NIKFLJ90111
|
Research Areas for HGK/MAP4K4
Find related products by research area and learn more about each of the different research areas below.
Phospho-SpecificProtein Kinase
![Western Blot HGK/MAP4K4 Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/HGK_AF6027_Western_Blot_9516.jpg)
