HARS2 Products

Description

The HARS2 gene encodes a 506 amino acid, 56kDA probable histidine--tRNA ligase (mitochondrial) protein that is member to the II family of aminoacyl-tRNA synthetases which charge tRNA with cognate amino acids. The HARS2 gene is located in a head-to-head orientation with HARS on chromosome 5, which is the location of where homologous genes share a bidirectional promoter. The protein works as an accessory in the regulation of protein biosynthesis through the synthesis of histidyl-transfer RNA. HARS2 is involved in gene expression and mitochondrian tRNA aminoacylation and has been known to interact with genes ICT1, AARS2, AASS, ABSB7, and ACAD9. HARS2 has been investigated in immunodeficiency, malaria, pneumonia, hearing loss, tuberculosis, schizophrenia, and ovarian dysgenesis.

Bioinformatics

Entrez	23438 Human
Uniprot	NM_012208 Human NP_036340 Human P49590 Human
Product By Gene ID	23438
Alternate Names	EC 6.1.1 EC 6.1.1.21 HARSLprobable histidyl-tRNA synthetase, mitochondrial HARS-related HARSRhistidine tRNA ligase 2, mitochondrial (putative) hisRS HisRS histidine translase Histidine--tRNA ligase Histidine--tRNA ligase-like histidyl-tRNA synthetase 2, mitochondrial (putative) histidyl-tRNA synthetase-like HO3histidine-tRNA ligase homolog