Species: Hu
Applications: WB, IHC, ICC/IF
Host: Goat Polyclonal
Species: Hu, Mu
Applications: WB
Host: Mouse Monoclonal
Species: Hu
Applications: WB
Host: Mouse Monoclonal
Species: Hu
Applications: WB
Species: Hu
Applications: WB, ELISA, MA, AP
Species: Hu
Applications: WB, ELISA, MA, AP
Species: Hu
Applications: AC
Description
Fos and Jun dimerize to form Activator Protein-1 (AP-1), a transcriptional factor that binds to the 12-O-tetradecanoylphorbol 13-acetate (TPA) response element (TRE) of several cellular and viral genes including human collagenase, metallothionein IIa, stromelysin, interleukin 2, SV40 and polyoma. Fos and Jun contain the 'leucine-zipper' motif that allows for dimerization and an adjacent basic domain required for biological activity. The functionally active form of Fos is in a heterodimer with a member of the Jun family. While Jun family members can form functional homodimers, studies indicate that Fos family members do not self-associate and therefore do not bind DNA on their own. The various dimers differ in their ability to transactivate AP-1 dependent genes.
Bioinformatics
| Entrez |
Mouse
Human
|
| Uniprot |
Human
Human
Human
Human
Human
|
| Product By Gene ID |
2354 |
| Alternate Names |
- activator protein 1
- AP-1
- DKFZp686C0818
- FBJ murine osteosarcoma viral oncogene homolog B
- G0S3G0/G1 switch regulatory protein 3
- GOS3
- GOSB
- MGC42291
- oncogene FOS-B
- protein fosB
|
Research Areas for FosB/G0S3
Find related products by research area and learn more about each of the different research areas below.
CancerTumor Suppressors
![Immunocytochemistry FosB/G0S3 Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/FosB_AF2214_Immunocytochemistry__Immunofluorescence_21634.jpg)
![Western Blot FosB/G0S3 Antibody (269928) [Unconjugated]](http://images.novusbio.com/fullsize2/FosB_MAB2214_Western_Blot_6019.jpg)
![Immunohistochemistry FosB/G0S3 Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/FosB_AF2214_Immunohistochemistry_9938.jpg)
