Species: Hu, Mu
Applications: WB
Host: Mouse Monoclonal
Species: Hu, Mu, Rt
Applications: WB, IHC, IP
Host: Rabbit Monoclonal
Species: Hu, Mu, Rt
Applications: WB, Simple Western
Host: Sheep Polyclonal
Species: Hu
Applications: WB, ELISA, MA, PAGE, AP
Species: Hu
Applications: AC
Species: Hu
Applications: AC
Description
Acetyl-CoA carboxylase 1 (ACC1) is a biotin dependent lipogenic enzyme that is highly expressed during adipogenesis. ACC1 catalyzes acetyl-CoA carboxylation, producing malonyl-CoA, a metabolite involved in energy homeostasis regulation. Malonyl-CoA is a two carbon donor in the synthesis of long-chain fatty acids and the elongation of fatty acids found in the cystol (1). ACC1 is regulated short-term by citrate, CoA, and palmitoyl-CoA through allosteric interactions. Nutrients and hormones can be both short-term (inducing reversible phosphorylations by such as AMPK) and long-term (transcription level regulation) regulators of ACC1 (2). Highly expressed in lipogenic tissues, ACC1 is found in liver, adipose, and lactating mammary gland (3). ACC1 has been implicated as a target in the development of anti-obesity drugs (4).
Bioinformatics
| Entrez |
Mouse
Human
Rat
|
| Uniprot |
Human
Human
Human
|
| Product By Gene ID |
31 |
| Alternate Names |
- ACACacetyl-CoA carboxylase 1
- ACC1ACC
- ACCA
- ACC-alpha
- acetyl-CoA carboxylase alpha
- acetyl-Coenzyme A carboxylase alpha
- EC 6.4.1.2
|
![Western Blot Acetyl-CoA Carboxylase alpha/ACACA Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/Acetyl-CoA_Carboxylase_alpha_AF6898_Western_Blot_11081.jpg)
![Simple Western Acetyl-CoA Carboxylase alpha/ACACA Antibody [Unconjugated]](http://images.novusbio.com/fullsize/antibody/af6898_human-mouse-rat-acetyl-coa-carboxylase-a-acaca-aff-pur-pab-simple-western-305202316425.jpg)
