gp130/CD130 Products

Description

CD130 is encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggested a critical role of the gene encoding this protein in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq]

Bioinformatics

Entrez	16195 Mouse 3572 Human
Uniprot	NM_002184 Human NP_002175 Human P40189 Human Q00560 Mouse
Product By Gene ID	3572
Alternate Names	CD130 antigen CD130 CDW130 CDw130 DKFZp564F053 gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form gp130 GP130 IL-6 receptor subunit beta IL-6R subunit beta IL-6RB IL-6R-beta interleukin 6 signal transducer (gp130, oncostatin M receptor) interleukin receptor beta chain interleukin-6 receptor subunit beta Interleukin-6 signal transducer Membrane glycoprotein 130 membrane glycoprotein gp130 Oncostatin-M receptor subunit alpha

Research Areas for gp130/CD130

Find related products by research area and learn more about each of the different research areas below.

Cancer
CD Markers
Immunology