Caspase-6 Products

Description

Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the initiation and execution of apoptosis. Caspase-6 is a major apoptotic executioner (1,2). It exists as a pro-domain protein and is cleaved by caspase-3 into two active subunits, an 18 kDa and a 10 kDa subunit (3). Caspase-6 cleaves among many different intracellular proteins, nuclear lamins. Lamins play a significant role in maintaining the integrity of the cell membrane, and their cleavage results in subsequent cellular breakdown and death (4).

Bioinformatics

Entrez	12368 Mouse 83584 Rat 839 Human
Uniprot	NM_001226 Human NP_001217 Human NP_001217 Human NP_001217.2 Human P55212 Human P55212 Human
Product By Gene ID	839
Alternate Names	Apoptotic protease Mch-2 CASP-6 caspase 6, apoptosis-related cysteine peptidase caspase 6, apoptosis-related cysteine protease caspase-6 EC 3.4.22 MCH2EC 3.4.22.59

Research Areas for Caspase-6

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Caspases
Phospho-Specific

Related Caspase-6 Blog Posts

Check out the latest blog posts on Caspase-6.

Pyroptosis: Mechanisms mediating cell death and pro-inflammatory cytokine release By Victoria OsinskiPyroptosis is an inflammatory form of programmed cell death characterized by the release of pro-inflammatory cytokines IL-1 beta and IL-18.1,10 It is a process distinct from apoptosis and necrosis (T...    Read more.

Read more Caspase-6 related blogs.