Factor VII (coagulation factor VII) is a 50 kD multidomain single chain plasma glycoprotein synthesized in the liver. It is a vitamin K-dependent serine protease essential for the extrinsic pathway of hemostasis, or blood coagulation. Factor VII circulates in the blood in a zymogen form that is converted to an active form (via factor IXa, factor Xa, factor XIIa, or thrombin).
