Histone

Bone and dentin are closely related tissues, formed when a type I collagen-rich extracellular matrix (ECM) is secreted from the osteoblasts or odontoblasts and subsequently mineralized. This process is tightly regulated by type I collagen plus a number of non-collagenous proteins, including members of the SIBLING (Small Integrin-Binding LIgand, N-linked Glycoprotein) family.

Histone modification is known to affect transcriptional access to chromatin. Therefore, high quality histone modification specific antibodies are necessary to understand and explain the specific roles that these epigenetic modifications play in transcription regulation. Unfortunately, many of the commercially available histone modification antibodies are designed against short immunizing peptides and lack specificity to the full-length modified histone.