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Apoptosis

IRE1α Regulates Dendritic Cell Function in Response to Viral Infection

Immunohistochemical analysis of IRE1 alpha in human epididymis.

By Natalia Gurule, PhD

 

Tags: 
Hepatitis C Virus
HCV
Herpes Simplex Virus 2
HSV-2
IRE1-alpha
Jnk
VSV-G Epitope Tag
VSV
XBP1
Apoptosis
dendritic cell
DC
Endoplasmic Reticulum
ER
Fibroblast
JNK Signaling Pathway
Macrophage
T cell
Unfolded protein response
UPR
virus
Natalia Gurule

Pyroptosis: Mechanisms mediating cell death and pro-inflammatory cytokine release

Immunohistochemical staining of formalin-fixed tissue of adenocarcinoma of the rectum using Caspase-1 antibody, peroxidase conjugate, and DAB chromogen.

By Victoria Osinski

Tags: 
Pyroptosis
Apoptosis
Necroptosis
Cytokines
immunology
Toll-Like Receptors
TLRs
PAMPs
DAMPs
AIM2
ASC/TMS1
CARD12
Caspase-1
Caspase-2
caspase-3
Caspase-4
caspase-5
Caspase-6
caspase-7
Caspase-8
Caspase-9
caspase-10
Caspase-11
DFNA1
GSDMDC1
IFI16
IL-1 beta/IL-1F2
IL-18/IL-1F4
NLRP1/NALP1
NLRP3/NALP3
NALP4
NALP6
NLRP7
NALP12
RIG-I
Victoria Osinksi

Transcriptional co-activators Yap1 and Taz control growth and development

Schematic of Hippo signaling pathway highlighting Yap and Taz proteins.

By Jamshed Arslan, Pharm D, PhD

Tags: 
Apoptosis
Cancer
Cell Proliferation
Embryonic Stem Cells
Hypoxia
Pluripotency
Stem Cells
Hippo
YAP1
TAZ
TAZ/WWTR1
TEF1
TEAD4
MCM3
MCM4
MCM6
MCM10
OCT1
Sox2
cIAP-1/HIAP-2
Survivin
Bcl-2
Mcl-1
cdx2
gata-3
HNF-4 alpha/NR2A1
Jagged 1
MYF-5
MYF6
Myogenin
Prox1
N-cadherin
Vimentin
SNAIL
Slug
TAK1
MDH2
HIF-1 alpha
Jamshed Arslan

The Ins and Outs of Survivin

Exosomes arise from the late endosomal compartment through inward budding of multivesicular bodies and may contain multiple proteins, lipids, DNA, RNAs and biomolecules of viruses/prions.

By Rachel M.A. Linger, Ph.D.

Tags: 
Cancer
Cancer Research
Apoptosis
Survivin
XIAP
ciap
birc8
Livin
NAIP
caspase-3
caspase-7
Caspase-9
Exosomes
tfr
ednrb-endothelin-r-type-b
Rachel M.A. Linger

Best genes to knockout to control autophagic flux

Autophagy interactive signaling pathway, Novus Biologicals, macroautophagy induction, autophagosome maturation, microautophagy, autolysosome, elongation

By Christina Towers, PhD

Tags: 
Autophagy
Autophagic flux
LC3
LC3B
LC3-II
Chloroquine
Bafilomycin
Autophagy Inhibitors
ATGs
ATG5
ATG7
Atg3
ATG12
stx17
p62-sqstm1
ATG13
Apoptosis
Christina Towers
autophagosome
Autophagy flux

A link between Autophagy and Apoptosis: Chat with First Author Brent E. Fitzwalter

Apoptosis poster Novus Biologicals

By Christina Towers, PhD.

Tags: 
Autophagy
autophagosome
Lysosome
Apoptosis
FOXO3A
PUMA

Killing two birds with one stone: Treating inflammation and cancer by inhibiting prolyl-4-hydroxylase-1

Bi-directional Cross-talk Between HIF1-alpha and NF kappa B

By Jamshed Arslan Pharm.D.

Tags: 
Hypoxia
HIF
PHD
Inflammation
Cancer
p53
NF-kB
Apoptosis
RelA/NFkB p65

Cleaner gone bad: Autophagy regulates motor neuron loss in spinal muscular atrophy

Autophagy Mechanisms

By Jamshed Arslan Pharm.D.

Tags: 
Autophagy
Cancer
ATG
Tumor
Immune System
immunity
T-Cells
LC3B
p62/SQSTM1
Apoptosis
inhibition
neuromuscular
spinal muscular atrophy
rapamycin
Jamshed Arslan
Western blot

The Many Connections Between Autophagy and Kidney Disease

Autophagy Pathway

By Yoskaly Lazo-Fernandez, PhD

Tags: 
Autophagy
mTORC1
ULK1
kidney disease
Apoptosis
Necrosis
Hypoxia
TOR/mTOR

Forecasting and Targeting a Rare Cancer with Hypoxia-Inducible Factor

H1alpha67

By Jamshed Arslan Pharm.D.

Tags: 
HIF-1 alpha
VEGFA
GLUT1
MIB-1
Hypoxia
Apoptosis

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