Antibody News

Caspase 7 (also known as CASP7, Mch3, ICE-LAP3, CMH-1) is a member of caspase family of cysteine proteases. It is an apoptosis-related cystein peptidase encoded by the CASP7 gene in humans. CASP7 homologous sequences have been identified in nearly all mammals. Similar to Caspase 3, Caspase-7 is an effector caspase and plays a key role in apoptotic execution. Once activated, Caspase-7 cleaves and activates downstream substrates, such as poly ADP-ribose polymerase (PARP), and causes cellular morphological and biomedical changes associated with apoptosis. During apoptosis, Caspase-7 is activated by initiator caspases (Caspase 8, Caspase 9 and Caspase 10) through...

Toll-like receptor 7 (TLR7) is a protein encoded by the TLR7 gene in humans and is a member of TLR family. TLRs controls host immune response against pathogens (e.g. viruses, bacteria and fungi) through recognition of pathogen-associated molecular patterns (PAMPs) which are specific to the microorganisms. These pathogen-associated molecular markers are class-specific and mutation-resistant and may be composed of proteins, carbohydrates, lipids, nucleic acids and/or combinations. Recognition of PAMPs by TLRs leads to a series of signaling events resulting in the production of cytokines necessary for the development of effective immunity.

The natural ligands of TLR7 were recently identified as single-stranded RNA (ssRNA), such as ssRNA from influenza viruses (2). The interaction between viral ssRNA and TLR7 occurs in an endosomal compartment in the cell...

Growth Associated Protein 43 (GAP43), also termed B-50, F1 or P-57, is a neuron-specific cytoplasmic protein encoded by the GAP-43 gene in humans. The expression of GAP 43 is associated with neural development and synaptic plasticity. A high level of GAP43 expression is observed in neuronal growth cones during development, at axonal regeneration after injury and is phosphorylated after long-term potentiation (1).

GAP43 protein is considered a crucial component of the axon and presynaptic terminal. GAP-43 knockout mice have been generated for the study of GAP-43 functions. Homozygous knockout...