Synapsin I Products

Description

Synapsin I is a neuron specific protein that is localized to nerve terminals. Synapsin Ia and Synapsin Ib are approximately 80,000 and 77,000 Daltons, respectively, and are collectively referred to as synapsin I. The synapsin protein is an excellent marker for synaptic terminals and it can be used to estimate synaptic density and or synaptogenesis. It is thought that synapsin I cross-links synaptic vesicles to the cytoskeleton and thereby limits the ability of these synaptic vesicles to move to active zones and fuse with the plasma membrane during exocytosis. In addition to their role in neurotransmission, the synapsins are also thought to play a role in synapse formation. The appearance of synapsin I immunoreactivity correlates precisely with the development of synapses in the CNS. The synapsin protein is an excellent marker for synaptic terminals and it can be used to estimate synaptic density and or synaptogenesis. The appearance of synapsin I was a precise indicator of synapse formation and that synapsin I immunocytochemistry provides a valuable tool for the study of synaptogenesis.

Bioinformatics

Entrez	20964 Mouse 24949 Rat 281510 Bovine 491858 Canine 6853 Human
Uniprot	NP_008881 Human P09951 Rat P17599 Bovine P17600 Human
Product By Gene ID	6853
Alternate Names	SYN1a SYN1b Synapsin 1 synapsin IBrain protein 4.1 synapsin-1 SYNI

Research Areas for Synapsin I

Find related products by research area and learn more about each of the different research areas below.

Cellular Markers
Neuronal Cell Markers
Neuroscience
Phospho-Specific

Related Synapsin I Blog Posts

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Synapsin I, a pre-synaptic marker Synapsin-I, also called Synapsin 1/Syn1, is an ~80 kDa protein (predicted mol. wt. 74.1 kDa) which belongs to the Synapsin family (Synapsin I, Synapsin II, Synapsin III). Synapsins are the evolutionarily conserved phospho-proteins which are associ...    Read more.

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